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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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|---|---|
Gene ID | 2309 |
Name | FOXO3 |
Synonym | AF6q21|FKHRL1|FKHRL1P2|FOXO2|FOXO3A;forkhead box O3;FOXO3;forkhead box O3 |
Definition | forkhead box O3A|forkhead box protein O3|forkhead homolog (rhabdomyosarcoma) like 1|forkhead in rhabdomyosarcoma-like 1|forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1 |
Position | 6q21 |
Gene Type | protein-coding |
Source | Count: 2; Pubmed_search,Generif |
Literature support | Count: 5 PubMed records as below. |
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Evidence Status |
Description |
reviewed | Inhibition of FOXO3 tumor suppressor function by betaTrCP1 through ubiquitin-mediated degradation in a tumor mouse model. |
reviewed | FOXO3a regulates glycolysis via transcriptional control of tumor suppressor TSC1. |
reviewed | tumor suppressor FOXO3 participates in the regulation of intestinal inflammation. |
reviewed | tumor suppressor Foxo3a is involved in the regulation of lipopolysaccharide-induced interleukin-8 in intestinal HT-29 cells. |
potential | Identification of FOXO3 and PRDM1 as tumor-suppressor gene candidates in NK-cell neoplasms by genomic and functional analyses. |
| More detail of all 5 literatures about FOXO3 | |
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Pathways and Diseases |
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Pathway | Signalling by NGF;Reactome;REACT:11061 |
Pathway | Insulin Pathway;PID Curated;200012 |
Pathway | Trk receptor signaling mediated by PI3K and PLC-gamma;PID Curated;200183 |
Pathway | Non-small cell lung cancer;KEGG PATHWAY;hsa05223 |
Pathway | Signaling events mediated by HDAC Class III;PID Curated;200020 |
Pathway | Neurotrophin signaling pathway;KEGG PATHWAY;hsa04722 |
Pathway | FoxO family signaling;PID Curated;200091 |
Pathway | Endometrial cancer;KEGG PATHWAY;hsa05213 |
Pathway | Chemokine signaling pathway;KEGG PATHWAY;hsa04062 |
Pathway | the igf-1 receptor and longevity;PID BioCarta;100115 |
Pathway | IL2 signaling events mediated by PI3K;PID Curated;200099 |
Pathway | role of nicotinic acetylcholine receptors in the regulation of apoptosis;PID BioCarta;100255 |
Pathway | Insulin/IGF pathway-protein kinase B signaling cascade;PANTHER;P00033 |
Pathway | Interleukin signaling pathway;PANTHER;P00036 |
Pathway | Signaling events mediated by Stem cell factor receptor (c-Kit);PID Curated;200156 |
Pathway | Validated targets of C-MYC transcriptional repression;PID Curated;200171 |
Pathway | PI3 kinase pathway;PANTHER;P00048 |
Pathway | Class I PI3K signaling events mediated by Akt;PID Curated;200169 |
Pathway | Class I PI3K signaling events;PID Curated;200098 |
Pathway | pten dependent cell cycle arrest and apoptosis;PID BioCarta;100058 |
Disease | Normalized brain volume;NHGRI |
Disease | IMMUNE;GAD |
Disease | normalized brain volume, multiple sclerosis;GAD |
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External Links |
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Links to Entrez Gene | 2309 |
Links to all GeneRIF Items | 2309 |
Links to iHOP | 2309 |
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Sequence Information |
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Nucleotide Sequence |
>2309 : length: 2022 atggcagaggcaccggcttccccggccccgctctctccgctcgaagtggagctggacccg gagttcgagccccagagccgtccgcgatcctgtacgtggcccctgcaaaggccggagctc caagcgagccctgccaagccctcgggggagacggccgccgactccatgatccccgaggag gaggacgatgaagacgacgaggacggcgggggacgggccggctcggccatggcgatcggc ggcggcggcgggagcggcacgctgggctccgggctgctccttgaggactcggcccgggtg ctggcacccggagggcaagaccccgggtctgggccagccaccgcggcgggcgggctgagc gggggtacacaggcgctgctgcagcctcagcaaccgctgccaccgccgcagccgggggcg gctgggggctccgggcagccgaggaaatgttcgtcgcggcggaacgcctggggaaacctg tcctacgcggacctgatcacccgcgccatcgagagctccccggacaaacggctcactctg tcccagatctacgagtggatggtgcgttgcgtgccctacttcaaggataagggcgacagc aacagctctgccggctggaagaactccatccggcacaacctgtcactgcatagtcgattc atgcgggtccagaatgagggaactggcaagagctcttggtggatcatcaaccctgatggg gggaagagcggaaaagccccccggcggcgggctgtctccatggacaatagcaacaagtat accaagagccgtggccgcgcagccaagaagaaggcagccctgcagacagcccccgaatca gctgacgacagtccctcccagctctccaagtggcctggcagccccacgtcacgcagcagt gatgagctggatgcgtggacggacttccgttcacgcaccaattctaacgccagcacagtc agtggccgcctgtcgcccatcatggcaagcacagagttggatgaagtccaggacgatgat gcgcctctctcgcccatgctctacagcagctcagccagcctgtcaccttcagtaagcaag ccgtgcacggtggaactgccacggctgactgatatggcaggcaccatgaatctgaatgat gggctgactgaaaacctcatggacgacctgctggataacatcacgctcccgccatcccag ccatcgcccactgggggactcatgcagcggagctctagcttcccgtataccaccaagggc tcgggcctgggctccccaaccagctcctttaacagcacggtgttcggaccttcatctctg aactccctacgccagtctcccatgcagaccatccaagagaacaagccagctaccttctct tccatgtcacactatggtaaccagacactccaggacctgctcacttcggactcacttagc cacagcgatgtcatgatgacacagtcggaccccttgatgtctcaggccagcaccgctgtg tctgcccagaattcccgccggaacgtgatgcttcgcaatgatccgatgatgtcctttgct gcccagcctaaccagggaagtttggtcaatcagaacttgctccaccaccagcaccaaacc cagggcgctcttggtggcagccgtgccttgtcgaattctgtcagcaacatgggcttgagt gagtccagcagccttgggtcagccaaacaccagcagcagtctcctgtcagccagtctatg caaaccctctcggactctctctcaggctcctccttgtactcaactagtgcaaacctgccc gtcatgggccatgagaagttccccagcgacttggacctggacatgttcaatgggagcttg gaatgtgacatggagtccattatccgtagtgaactcatggatgctgatgggttggatttt aactttgattccctcatctccacacagaatgttgttggtttgaacgtggggaacttcact ggtgctaagcaggcctcatctcagagctgggtgccaggctga |
Protein Sequence |
>2309 : length: 673 MAEAPASPAPLSPLEVELDPEFEPQSRPRSCTWPLQRPELQASPAKPSGETAADSMIPEE EDDEDDEDGGGRAGSAMAIGGGGGSGTLGSGLLLEDSARVLAPGGQDPGSGPATAAGGLS GGTQALLQPQQPLPPPQPGAAGGSGQPRKCSSRRNAWGNLSYADLITRAIESSPDKRLTL SQIYEWMVRCVPYFKDKGDSNSSAGWKNSIRHNLSLHSRFMRVQNEGTGKSSWWIINPDG GKSGKAPRRRAVSMDNSNKYTKSRGRAAKKKAALQTAPESADDSPSQLSKWPGSPTSRSS DELDAWTDFRSRTNSNASTVSGRLSPIMASTELDEVQDDDAPLSPMLYSSSASLSPSVSK PCTVELPRLTDMAGTMNLNDGLTENLMDDLLDNITLPPSQPSPTGGLMQRSSSFPYTTKG SGLGSPTSSFNSTVFGPSSLNSLRQSPMQTIQENKPATFSSMSHYGNQTLQDLLTSDSLS HSDVMMTQSDPLMSQASTAVSAQNSRRNVMLRNDPMMSFAAQPNQGSLVNQNLLHHQHQT QGALGGSRALSNSVSNMGLSESSSLGSAKHQQQSPVSQSMQTLSDSLSGSSLYSTSANLP VMGHEKFPSDLDLDMFNGSLECDMESIIRSELMDADGLDFNFDSLISTQNVVGLNVGNFT GAKQASSQSWVPG |