Bioinformatics and Systems Medicine Laboratory
General information | Expression | Regulation | Mutation | Interaction

Basic Information

Gene ID

2309

Name

FOXO3

Synonym

AF6q21|FKHRL1|FKHRL1P2|FOXO2|FOXO3A;forkhead box O3;FOXO3;forkhead box O3

Definition

forkhead box O3A|forkhead box protein O3|forkhead homolog (rhabdomyosarcoma) like 1|forkhead in rhabdomyosarcoma-like 1|forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1

Position

6q21

Gene Type

protein-coding

Source

Count: 2; Pubmed_search,Generif

Literature support

Count: 5 PubMed records as below.

Evidence Status

Description

reviewed

Inhibition of FOXO3 tumor suppressor function by betaTrCP1 through ubiquitin-mediated degradation in a tumor mouse model.

reviewed

FOXO3a regulates glycolysis via transcriptional control of tumor suppressor TSC1.

reviewed

tumor suppressor FOXO3 participates in the regulation of intestinal inflammation.

reviewed

tumor suppressor Foxo3a is involved in the regulation of lipopolysaccharide-induced interleukin-8 in intestinal HT-29 cells.

potential

Identification of FOXO3 and PRDM1 as tumor-suppressor gene candidates in NK-cell neoplasms by genomic and functional analyses.
More detail of all 5 literatures about FOXO3

Pathways and Diseases

Pathway

Signalling by NGF;Reactome;REACT:11061

Pathway

Insulin Pathway;PID Curated;200012

Pathway

Trk receptor signaling mediated by PI3K and PLC-gamma;PID Curated;200183

Pathway

Non-small cell lung cancer;KEGG PATHWAY;hsa05223

Pathway

Signaling events mediated by HDAC Class III;PID Curated;200020

Pathway

Neurotrophin signaling pathway;KEGG PATHWAY;hsa04722

Pathway

FoxO family signaling;PID Curated;200091

Pathway

Endometrial cancer;KEGG PATHWAY;hsa05213

Pathway

Chemokine signaling pathway;KEGG PATHWAY;hsa04062

Pathway

the igf-1 receptor and longevity;PID BioCarta;100115

Pathway

IL2 signaling events mediated by PI3K;PID Curated;200099

Pathway

role of nicotinic acetylcholine receptors in the regulation of apoptosis;PID BioCarta;100255

Pathway

Insulin/IGF pathway-protein kinase B signaling cascade;PANTHER;P00033

Pathway

Interleukin signaling pathway;PANTHER;P00036

Pathway

Signaling events mediated by Stem cell factor receptor (c-Kit);PID Curated;200156

Pathway

Validated targets of C-MYC transcriptional repression;PID Curated;200171

Pathway

PI3 kinase pathway;PANTHER;P00048

Pathway

Class I PI3K signaling events mediated by Akt;PID Curated;200169

Pathway

Class I PI3K signaling events;PID Curated;200098

Pathway

pten dependent cell cycle arrest and apoptosis;PID BioCarta;100058

Disease

Normalized brain volume;NHGRI

Disease

IMMUNE;GAD

Disease

normalized brain volume, multiple sclerosis;GAD

External Links

Links to Entrez Gene

2309

Links to all GeneRIF Items

2309

Links to iHOP

2309

Sequence Information

Nucleotide Sequence

>2309 : length: 2022
atggcagaggcaccggcttccccggccccgctctctccgctcgaagtggagctggacccg
gagttcgagccccagagccgtccgcgatcctgtacgtggcccctgcaaaggccggagctc
caagcgagccctgccaagccctcgggggagacggccgccgactccatgatccccgaggag
gaggacgatgaagacgacgaggacggcgggggacgggccggctcggccatggcgatcggc
ggcggcggcgggagcggcacgctgggctccgggctgctccttgaggactcggcccgggtg
ctggcacccggagggcaagaccccgggtctgggccagccaccgcggcgggcgggctgagc
gggggtacacaggcgctgctgcagcctcagcaaccgctgccaccgccgcagccgggggcg
gctgggggctccgggcagccgaggaaatgttcgtcgcggcggaacgcctggggaaacctg
tcctacgcggacctgatcacccgcgccatcgagagctccccggacaaacggctcactctg
tcccagatctacgagtggatggtgcgttgcgtgccctacttcaaggataagggcgacagc
aacagctctgccggctggaagaactccatccggcacaacctgtcactgcatagtcgattc
atgcgggtccagaatgagggaactggcaagagctcttggtggatcatcaaccctgatggg
gggaagagcggaaaagccccccggcggcgggctgtctccatggacaatagcaacaagtat
accaagagccgtggccgcgcagccaagaagaaggcagccctgcagacagcccccgaatca
gctgacgacagtccctcccagctctccaagtggcctggcagccccacgtcacgcagcagt
gatgagctggatgcgtggacggacttccgttcacgcaccaattctaacgccagcacagtc
agtggccgcctgtcgcccatcatggcaagcacagagttggatgaagtccaggacgatgat
gcgcctctctcgcccatgctctacagcagctcagccagcctgtcaccttcagtaagcaag
ccgtgcacggtggaactgccacggctgactgatatggcaggcaccatgaatctgaatgat
gggctgactgaaaacctcatggacgacctgctggataacatcacgctcccgccatcccag
ccatcgcccactgggggactcatgcagcggagctctagcttcccgtataccaccaagggc
tcgggcctgggctccccaaccagctcctttaacagcacggtgttcggaccttcatctctg
aactccctacgccagtctcccatgcagaccatccaagagaacaagccagctaccttctct
tccatgtcacactatggtaaccagacactccaggacctgctcacttcggactcacttagc
cacagcgatgtcatgatgacacagtcggaccccttgatgtctcaggccagcaccgctgtg
tctgcccagaattcccgccggaacgtgatgcttcgcaatgatccgatgatgtcctttgct
gcccagcctaaccagggaagtttggtcaatcagaacttgctccaccaccagcaccaaacc
cagggcgctcttggtggcagccgtgccttgtcgaattctgtcagcaacatgggcttgagt
gagtccagcagccttgggtcagccaaacaccagcagcagtctcctgtcagccagtctatg
caaaccctctcggactctctctcaggctcctccttgtactcaactagtgcaaacctgccc
gtcatgggccatgagaagttccccagcgacttggacctggacatgttcaatgggagcttg
gaatgtgacatggagtccattatccgtagtgaactcatggatgctgatgggttggatttt
aactttgattccctcatctccacacagaatgttgttggtttgaacgtggggaacttcact
ggtgctaagcaggcctcatctcagagctgggtgccaggctga

Protein Sequence

>2309 : length: 673
MAEAPASPAPLSPLEVELDPEFEPQSRPRSCTWPLQRPELQASPAKPSGETAADSMIPEE
EDDEDDEDGGGRAGSAMAIGGGGGSGTLGSGLLLEDSARVLAPGGQDPGSGPATAAGGLS
GGTQALLQPQQPLPPPQPGAAGGSGQPRKCSSRRNAWGNLSYADLITRAIESSPDKRLTL
SQIYEWMVRCVPYFKDKGDSNSSAGWKNSIRHNLSLHSRFMRVQNEGTGKSSWWIINPDG
GKSGKAPRRRAVSMDNSNKYTKSRGRAAKKKAALQTAPESADDSPSQLSKWPGSPTSRSS
DELDAWTDFRSRTNSNASTVSGRLSPIMASTELDEVQDDDAPLSPMLYSSSASLSPSVSK
PCTVELPRLTDMAGTMNLNDGLTENLMDDLLDNITLPPSQPSPTGGLMQRSSSFPYTTKG
SGLGSPTSSFNSTVFGPSSLNSLRQSPMQTIQENKPATFSSMSHYGNQTLQDLLTSDSLS
HSDVMMTQSDPLMSQASTAVSAQNSRRNVMLRNDPMMSFAAQPNQGSLVNQNLLHHQHQT
QGALGGSRALSNSVSNMGLSESSSLGSAKHQQQSPVSQSMQTLSDSLSGSSLYSTSANLP
VMGHEKFPSDLDLDMFNGSLECDMESIIRSELMDADGLDFNFDSLISTQNVVGLNVGNFT
GAKQASSQSWVPG



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