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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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|---|---|
Gene ID | 27429 |
Name | HTRA2 |
Synonymous | OMI|PARK13|PRSS25;HtrA serine peptidase 2;HTRA2;HtrA serine peptidase 2 |
Definition | HtrA-like serine protease|Omi stress-regulated endoprotease|high temperature requirement protein A2|protease, serine, 25|serine protease 25|serine protease HTRA2, mitochondrial|serine proteinase OMI |
Position | 2p12 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors | | Top | |
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Regulation From TransFac database |
Omi(h) + APP(m.s.) <==> Omi(h):APP(m.s.) (binding) | Omi(h) --> Omi(h) (translocation) | Omi(h) + ATP --AKT(h)--> Omi(h){p} + ADP (phosphorylation) | PEA15(h) + Omi(h) <==> PEA15(h):Omi(h) (binding) | Omi(h) + PEA15(h) <==> Omi(h):PEA15(h) (binding) | Omi(h) + PEA-15(m.s.) <==> Omi(h):PEA-15(m.s.) (binding) | XIAP(h) + Omi(h) <==> XIAP(h):Omi(h) (binding) | Omi(h) + XIAP(h) <==> Omi(h):XIAP(h) (binding) | apollon(h) + Omi(h) <==> apollon(h):Omi(h) (binding) | Omi(h) + apollon(m) <==> Omi(h):apollon(m) (binding) | Omi(h) + cIAP-1(m.s.) <==> Omi(h):cIAP-1(m.s.) (binding) | Omi(h) --> Omi-p38(h) + protein remnants (cleavage) | HTRA2(h) --> Omi(h) (expression). | Omi(h) --> Omi(h) (translocation) | cIAP-1(h) --Omi(h)--> protein remnants (processing) | cIAP-2(h) --Omi(h)--> protein remnants (processing) | XIAP(h) --Omi(h)--> protein remnants (processing) | DIAP1(d) --Omi(h)--> protein remnants (processing) | ML-IAP1(h) --Omi(h)--> protein remnants (processing) | ML-IAP2(h) --Omi(h)--> protein remnants (processing) | XIAP(h) --Omi(h)--> protein remnants (cleavage) | cIAP-2(h) --Omi(h)--> protein remnants (cleavage) | XIAP(m.s.) --Omi(h)--> protein remnants (cleavage) | cIAP-1(m.s.) --Omi(h)--> protein remnants (cleavage) | cIAP-2(m.s.) --Omi(h)--> protein remnants (cleavage) | apollon(m) --Omi(h)--> protein remnants (degradation) | proCaspase-3(v.s.) + n ubiquitin(v.s.) --E1(v.s.),UbcH6(h),cIAP-1(h)--> proCaspase-3(v.s.){ub(n)} (ubiquitination) | proCaspase-9(v.s.) + n ubiquitin(v.s.) --E1(v.s.),UbcH6(h),cIAP-1(h)--> proCaspase-9(v.s.){ub(n)} (ubiquitination) | HTRA2(h) --> Omi-isoform1(h) (expression). | HTRA2(h) --> Omi-isoform2(h) (expression). | HTRA2(h) --> Omi-isoform3(h) (expression). | HTRA2(h) --> Omi-isoform4(h) (expression). |
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Post Transcriptional Modification From dbPTM | | Top | |
There is no record for HTRA2 |
Methylation Profile From DiseaseMeth database | | Top | |
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Chromosome |
Location |
Source |
|---|---|---|
chr2 |
Promoter: 74608540 - 74610540 | Agilent_014791 |
chr2 |
Promoter: 74608540 - 74610540 | GSE27584 |
chr2 |
Promoter: 74608540 - 74610540 | GSE27584 |
chr2 |
Promoter: 74608540 - 74610540 | Agilent_014791_44K |
chr2 |
Promoter: 74608540 - 74610540 | Agilent_014791_44K |