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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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Gene ID | 3488 |
Name | IGFBP5 |
Synonymous | IBP5;insulin-like growth factor binding protein 5;IGFBP5;insulin-like growth factor binding protein 5 |
Definition | IBP-5|IGF-binding protein 5|IGFBP-5|insulin-like growth factor-binding protein 5 |
Position | 2q33-q36 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors | | Top | |
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Regulation From TransFac database |
IGFBP-5(h) --PAPP-A2(h)--> protein remnants (degradation) | IGF-2(h) + IGFBP-5(h) <==> IGF-2(h):IGFBP-5(h) (binding) | IGF-1(h) + IGFBP-5(h) <==> IGF-1(h):IGFBP-5(h) (binding) | IGFBP5(h) --> IGFBP-5(h) (expression). | IGF-1(h) + IGFBP-5(h) <==> IGF-1(h):IGFBP-5(h) (binding) | IGF-2(m.s.) + IGFBP-5(h) <==> IGF-2(m.s.):IGFBP-5(h) (binding) | IGF-2(h) + IGFBP-5(h) <==> IGF-2(h):IGFBP-5(h) (binding) | IGF-2(h) + IGFBP-5(h) <==> IGF-2(h):IGFBP-5(h) (binding) | ALS(h) + IGF-2(h) + IGFBP-5(h) <==> ALS(h):IGF-2(h):IGFBP-5(h) (binding) | ALS(h) + IGF-2(h) + IGFBP-5(h) <==> ALS(h):IGF-2(h):IGFBP-5(h) (binding) | IGFBP-5(h) + RXR-alpha(h) <==> IGFBP-5(h):RXR-alpha(h) (binding) | IGFBP-5(h) + VDR(h) <==> IGFBP-5(h):VDR(h) (binding) | IGFBP-5(h) --> col1A1(h) (increase of abundance) | IGFBP-5(h) --kallikrein-2(h)--> IGFBP5-p27(h) + protein remnants (cleavage) | IGFBP-5(h) --kallikrein-2(h)--> IGFBP5-p18(h) + protein remnants (cleavage) | IGFBP-5(h) + TSP-1(h) <==> IGFBP-5(h):TSP-1(h) (binding) | IGFBP-5(h) + OPN(h) <==> IGFBP-5(h):OPN(h) (binding) | IGFBP5(h) --> IGFBP-5(h) (expression). | IGFBP5(h) --> igfbp5(h) (expression). | hsa-miR-140 --/ igfbp5(h) (increase of mRNA decay). |
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Post Transcriptional Modification From dbPTM | | Top | |
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Location (AA) |
PTM type |
Literature |
Database |
172 | O-linked (HexNAc...). | Swiss-Prot 53.0 | P2459 | T | P24593 | OGlycBase6.0 |
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Methylation Profile From DiseaseMeth database | | Top | |
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Chromosome |
Location |
Source |
|---|---|---|
chr2 |
Promoter: 217268016 - 217270016 | GoldenGate_Methylation_Cancer_Panel_I |
chr2 |
Promoter: 217268016 - 217270016 | GSE27584 |