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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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|---|---|
Gene ID | 4303 |
Name | FOXO4 |
Synonymous | AFX|AFX1|MLLT7;forkhead box O4;FOXO4;forkhead box O4 |
Definition | fork head domain transcription factor AFX1|forkhead box protein O4|myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 7 |
Position | Xq13.1 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors | | Top | |
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Regulation From TransFac database |
foxo4(h) + ATP --AKT-1(h)--> foxo4(h){pT28}{pS193}{pS258} + ADP (phosphorylation) | foxo4(h) + ATP --AKT-1(r)--> foxo4(h){pT28}{pS193}{pS258} + ADP (phosphorylation) | Ran(h):GTP + CRM1(h) + foxo4(h) <==> CRM1(h):foxo4(h):Ran(h):GTP (binding; translocation) | foxo4(h) + ATP --> foxo4(h){pT447}{pT451} + ADP (phosphorylation) | foxo4(h) --> CAV1(h) (transactivation) | foxo4(h) + acetyl-CoA --CBP(h)--> foxo4(h){ace} + CoA (acetylation) | smad4(h) + foxo4(h) <==> smad4(h):foxo4(h) (binding) | foxo4(h) + Smad3(m.s.) <==> foxo4(h):Smad3(m.s.) (binding) | Smad4(m.s.) + foxo4(h) <==> Smad4(m.s.):foxo4(h) (binding) | Pin1(h) + foxo4(h) <==> Pin1(h):foxo4(h) (binding) | foxo4(h) --> foxo4(h) (expression). | foxo4(h){ace} --SIRT1(h)--> foxo4(h) + acetyl (deacetylation) | foxo4(h) --> IGFBP1(h) (DNA binding; transactivation) | foxo4(h) --> RBL2(h) (DNA binding; transactivation). | foxo4(h) --> BCL6(h) (DNA binding; transactivation). | foxo4(h) --> foxo4(h) (expression). | FOXO4(h) --> foxo4b(h) (expression). | FOXO4(h) --> foxo4a(h) (expression). |
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Post Transcriptional Modification From dbPTM | | Top | |
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Location (AA) |
PTM type |
Literature |
Database |
32 | Phosphothreonine (by PKB/AKT1). | Swiss-Prot 53.0 | 197 | Phosphoserine (by PKB/AKT1). | Swiss-Prot 53.0 | 262 | Phosphoserine (by PKB/AKT1). | Swiss-Prot 53.0 | 455 | Phosphothreonine (MAPK8;MAPK9) | 15538382 | Phospho.ELM 6.0 | 32 | Phosphothreonine | 15538382;11896584 | Phospho.ELM 6.0 | 451 | Phosphothreonine (MAPK8;MAPK9;) | 11689711;15538382 | Phospho.ELM 6.0 |
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Methylation Profile From DiseaseMeth database | | Top | |
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Chromosome |
Location |
Source |
|---|---|---|
chrX |
Promoter: 70231251 - 70233251 | GSE27584 |
chrX |
Promoter: 70231251 - 70233251 | Agilent_014791_44K |