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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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|---|---|
Gene ID | 5371 |
Name | PML |
Synonymous | MYL|PP8675|RNF71|TRIM19;promyelocytic leukemia;PML;promyelocytic leukemia |
Definition | RING finger protein 71|probable transcription factor PML|promyelocytic leukemia protein|promyelocytic leukemia, inducer of|protein PML|tripartite motif protein TRIM19|tripartite motif-containing protein 19 |
Position | 15q22 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors | | Top | |
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Regulation From TransFac database |
hipk2(h) + PML-3(h) <==> hipk2(h):PML-3(h) (binding) | PML-3(h) + p53(h) <==> PML-3(h):p53(h) (binding) | SNURF(r) + PML-3(h) <==> SNURF(r):PML-3(h) (binding) | PML(h) --> PML-3(h) (expression). | PML(h) + mdm2(h) <==> PML(h):mdm2(h) (binding) | PML(h) + p73alpha(h) <==> PML(h):p73alpha(h) (binding) | eIF-4E(m.s.) + PML(h) <==> eIF-4E(m.s.):PML(h) (binding) | eIF-4E(h) + PML(h) <==> eIF-4E(h):PML(h) (binding) | eIF-4E(m) + PML(h) <==> eIF-4E(m):PML(h) (binding) | PML(h) --/ cyclinD1(m) (inhibition) | Hex(m.s.) + PML(h) <==> Hex(m.s.):PML(h) (binding) | PML(h) + GAPD(h) <==> PML(h):GAPD(h) (binding) | GATA-2(h) + PML(h) <==> GATA-2(h):PML(h) (binding) | NCOR(h) + PML(h) <==> NCOR(h):PML(h) (binding) | sin3a(h) + PML(h) <==> sin3a(h):PML(h) (binding) | HDAC1(h) + PML(h) <==> HDAC1(h):PML(h) (binding) | PML(h) + c-Ski(h) <==> PML(h):c-Ski(h) (binding) | NR1B1(h) + PML(h) <==> NR1B1(h):PML(h) (binding) | c-Jun(h) + PML(h) <==> c-Jun(h):PML(h) (binding) | PML(h) + Smad2(m.s.) <==> PML(h):Smad2(m.s.) (binding) | Smad3(h) + PML(h) <==> Smad3(h):PML(h) (binding) | PML(h) + SARA(m.s.) <==> PML(h):SARA(m.s.) (binding) | PML(h) + Smad3(h) + SARA(m.s.) <==> PML(h):Smad3(h):SARA(m.s.) (binding) | PML(h) + TGFbetaR-I(m.s.) <==> PML(h):TGFbetaR-I(m.s.) (binding) | PML(h) + TGFbetaR-II(m.s.) <==> PML(h):TGFbetaR-II(m.s.) (binding) | Daxx(h) + PML(h) <==> Daxx(h):PML(h) (binding) | Daxx(h) + PML(h) <==> Daxx(h):PML(h) (binding) | PML(h) + sumo1(m.s.) --> PML(h){sumo} (sumoylation) | PML(h) + c-Myc(m) <==> PML(h):c-Myc(m) (binding) | PML(h) + c-Myc(m) <==> PML(h):c-Myc(m) (binding) | PML(h) + c-Myc(m.s.) <==> PML(h):c-Myc(m.s.) (binding) | PML(h) + sumo1(h) --> PML(h){sumo} (sumoylation) | PML(h) --> PML(h) (translocation) | ZNF198(m.s.) + PML(h) <==> ZNF198(m.s.):PML(h) (binding) | sumo1(h) + PML(h) <==> sumo1(h):PML(h) (binding) | ZNF198(h) + PML(h) <==> ZNF198(h):PML(h) (binding) | PML(h) + SUMO2(h) --> PML(h){sumo2} (sumoylation) | PML(h) + Daxx(m) <==> PML(h):Daxx(m) (binding) | Hex(h) + PML(h) <==> Hex(h):PML(h) (binding) | Pin1(h) + PML(h) <==> Pin1(h):PML(h) (binding) | PML(h) --> PML(h) (expression). | PML(h) --> PML(h) (translocation) | IFNgamma(h) --> PML(h) (increase of abundance) | IFNalpha(m.s.) --> PML(h) (increase of abundance) | IFNalpha2b(h) --> PML(h) (increase of abundance) | PML(h) --> PML-1(h) (expression). | TIF1(m) + PML-2(h) <==> TIF1(m):PML-2(h) (binding) | PML-2(h) + CBP(m.s.) <==> PML-2(h):CBP(m.s.) (binding) | PML(h) --> PML-2(h) (expression). | PML(h) --> PML-3B(h) (expression). | PML-X(h) + ATP --ATR(h)--> ADP + PML(h){p} (phosphorylation) | PML-X(h) + mdm2(h) <==> PML-X(h):mdm2(h) (binding) | PML-X(h) + mdm2(m) <==> PML-X(h):mdm2(m) (binding) | PML-X(h) + rpl11(m) <==> PML-X(h):rpl11(m) (binding) | PML-X(h) + rpl11(h) <==> PML-X(h):rpl11(h) (binding) | HDAC3(m.s.) + PML-X(h) <==> HDAC3(m.s.):PML-X(h) (binding) | HDAC1(m.s.) + PML-X(h) <==> HDAC1(m.s.):PML-X(h) (binding) | HDAC3(h) + PML-X(h) <==> HDAC3(h):PML-X(h) (binding) | hdac2(m.s.) + PML-X(h) <==> hdac2(m.s.):PML-X(h) (binding) | PML(h) --> PML-X(h) (expression). |
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Post Transcriptional Modification From dbPTM | | Top | |
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Location (AA) |
PTM type |
Literature |
Database |
8 | Phosphoserine. | Swiss-Prot 53.0 | 403 | Phosphoserine. | Swiss-Prot 53.0 | 504 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 505 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 518 | Phosphoserine. | Swiss-Prot 53.0 | 527 | Phosphoserine. | Swiss-Prot 53.0 | 530 | Phosphoserine. | Swiss-Prot 53.0 | 535 | Phosphoserine. | Swiss-Prot 53.0 | 560 | Phosphoserine. | Swiss-Prot 53.0 | 561 | Phosphoserine. | Swiss-Prot 53.0 | 562 | Phosphoserine. | Swiss-Prot 53.0 | 565 | Phosphoserine. | Swiss-Prot 53.0 | 530 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 578 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 579 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 580 | Phosphoserine | 17081983 | Phospho.ELM 6.0 |
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Methylation Profile From DiseaseMeth database | | Top | |
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Chromosome |
Location |
Source |
|---|---|---|
chr15 |
Promoter: 72072567 - 72074567 | GSE27584 |
chr15 |
Promoter: 72072567 - 72074567 | GSE27584 |
chr15 |
Promoter: 72072567 - 72074567 | GSE27584 |
chr15 |
Promoter: 72072567 - 72074567 | GSE27584 |
chr15 |
Promoter: 72072567 - 72074567 | GSE27584 |
chr15 |
Promoter: 72072567 - 72074567 | GSE27584 |
chr15 |
Promoter: 72072567 - 72074567 | GSE27584 |
chr15 |
Promoter: 72072567 - 72074567 | GSE27584 |
chr15 |
Promoter: 72072567 - 72074567 | GSE27584 |