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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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Gene ID | 5610 |
Name | EIF2AK2 |
Synonymous | EIF2AK1|PKR|PRKR;eukaryotic translation initiation factor 2-alpha kinase 2;EIF2AK2;eukaryotic translation initiation factor 2-alpha kinase 2 |
Definition | P1/eIF-2A protein kinase|double stranded RNA activated protein kinase|eIF-2A protein kinase 2|interferon-induced, double-stranded RNA-activated protein kinase|interferon-inducible elF2alpha kinase|p68 kinase|protein kinase, interferon-inducible double str |
Position | 2p22-p21 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors | | Top | |
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Regulation From TransFac database |
PACT(h) + PKR(h) <==> PACT(h):PKR(h) (binding) | TIRAP(h) + PKR(h) <==> TIRAP(h):PKR(h) (binding) | PKR(h) + IKK-alpha(h):IKK-beta(h):(IKK-gamma(h))2 <==> PKR(h):IKK-alpha(h):IKK-beta(h):(IKK-gamma(h))2 (binding) | PKR(h) + DRBP76(h) <==> PKR(h):DRBP76(h) (binding) | NF45(h) + NF90(h) + PKR(h) <==> NF45(h):NF90(h):PKR(h) (binding) | SPNR(r) + PKR(h) <==> SPNR(r):PKR(h) (binding) | PKR(h) + ILF3(h) <==> PKR(h):ILF3(h) (binding) | 2 PKR(h) <==> PKR(h):PKR(h) (oligomerization) | PKR(h) + trbp-isoform1(h) <==> PKR(h):trbp-isoform1(h) (binding) | PKR(h) + STAT3(h) <==> PKR(h):STAT3(h) (binding) | PDGFRbeta(m) + PKR(h) <==> PDGFRbeta(m):PKR(h) (binding) | TEBP(h) + Hsp90(h) + PKR(h) <==> TEBP(h):Hsp90(h):PKR(h) (binding) | PKR(h) + p53(h) <==> PKR(h):p53(h) (binding) | TRAF6(h) + TAB2(h) + TAK1(h) + PKR(h) <==> TRAF6(h):TAB2(h):TAK1(h):PKR(h) (binding) | MKK6(m.s.) + PKR(h) <==> MKK6(m.s.):PKR(h) (binding) | PKR(h) + HCV-NS5A-1A(HCV1A) <==> PKR(h):HCV-NS5A-1A(HCV1A) (binding) | PKR(h) + ATP --> PKR(h){p} + ADP (phosphorylation; automodification) | PRKR(h) --> PKR(h) (expression). | PKR(h):p53(h) + ATP --> PKR(h) + p53(h){pS392} + ADP (phosphorylation; dissociation) | IFNalpha2(m.s.) --> PKR(h) (increase of abundance) | HCV-NS3-1A(HCV1A):HCV-NS4A-1A(HCV1A) --/ PKR(h) (decrease of abundance) | IFNbeta(h) --> PKR(h) (increase of abundance) | H2O2 --> PKR(h) (increase of abundance) | eIF-2alpha(m.s.) + ATP --PKR(h)--> eIF-2alpha(m.s.){p} + ADP (phosphorylation) | PKR(h) + HCV-NS5A-1A(HCV1A) <==> PKR(h):HCV-NS5A-1A(HCV1A) (binding) | HCV-NS5A-1B(HCV1B) + PKR(h) <==> HCV-NS5A-1B(HCV1B):PKR(h) (binding) | p58IPK(h) + PKR(h) <==> p58IPK(h):PKR(h) (binding) | PKR(h) + HCV-NS5A-1B(HCV1B) <==> PKR(h):HCV-NS5A-1B(HCV1B) (binding) | HCV-NS5A-1A-H(HCV1AH) + PKR(h) <==> HCV-NS5A-1A-H(HCV1AH):PKR(h) (binding) | PKR(h) + TRAF3(m.s.) <==> PKR(h):TRAF3(m.s.) (binding) | PRKR(h) --> PKR(h) (expression). | MKK6(h) + ATP --PKR(h)--> MKK6(h){p} + ADP (phosphorylation) | EIF-2alpha(h) + ATP --PKR(h)--> ADP + EIF-2alpha(h){p} (phosphorylation) | B56alpha(h) + ATP --PKR(h)--> B56alpha(h){p} + ADP (phosphorylation) | ATF-2(m.s.) + ATP --PKR(h)--> ATF-2(m.s.){p} + ADP (phosphorylation) |
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Post Transcriptional Modification From dbPTM | | Top | |
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Location (AA) |
PTM type |
Literature |
Database |
83 | Phosphoserine (by autocatalysis)(Probable). | Swiss-Prot 53.0 | 88 | Phosphothreonine (by autocatalysis)(Probable). | Swiss-Prot 53.0 | 89 | Phosphothreonine (by autocatalysis)(Probable). | Swiss-Prot 53.0 | 90 | Phosphothreonine (by autocatalysis)(Probable). | Swiss-Prot 53.0 | 242 | Phosphoserine (by autocatalysis)(Probable). | Swiss-Prot 53.0 | 255 | Phosphothreonine (by autocatalysis)(Probable). | Swiss-Prot 53.0 | 258 | Phosphothreonine (by autocatalysis)(Probable). | Swiss-Prot 53.0 | 446 | Phosphothreonine (by autocatalysis). | Swiss-Prot 53.0 | 451 | Phosphothreonine (by autocatalysis). | Swiss-Prot 53.0 | 242 | Phosphoserine (EIF2AK2) | 9528799;8887659;11152499 | Phospho.ELM 6.0 | 255 | Phosphothreonine (EIF2AK2) | 9528799;8887659;11152499 | Phospho.ELM 6.0 | 258 | Phosphothreonine (EIF2AK2) | 11337501;9528799;8887659 | Phospho.ELM 6.0 | 83 | Phosphoserine (EIF2AK2) | 11152499 | Phospho.ELM 6.0 | 88 | Phosphothreonine (EIF2AK2) | 11152499 | Phospho.ELM 6.0 | 89 | Phosphothreonine (EIF2AK2) | 11152499 | Phospho.ELM 6.0 | 90 | Phosphothreonine (EIF2AK2) | 11152499 | Phospho.ELM 6.0 | 446 | Phosphothreonine (EIF2AK2) | 11337501 | Phospho.ELM 6.0 | 451 | Phosphothreonine (EIF2AK2) | 11337501 | Phospho.ELM 6.0 | 101 | Phosphotyrosine | 16373505 | Phospho.ELM 6.0 | 293 | Phosphotyrosine | 16373505 | Phospho.ELM 6.0 | 162 | Phosphotyrosine | 16373505 | Phospho.ELM 6.0 |
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Methylation Profile From DiseaseMeth database | | Top | |
There is no record for EIF2AK2 |