Bioinformatics and Systems Medicine Laboratory
General information | Expression | Regulation | Mutation | Interaction

Basic Information

Gene ID

5771

Name

PTPN2

Synonymous

PTN2|PTPT|TC-PTP|TCELLPTP|TCPTP;protein tyrosine phosphatase, non-receptor type 2;PTPN2;protein tyrosine phosphatase, non-receptor type 2

Definition

T-cell protein tyrosine phosphatase|tyrosine-protein phosphatase non-receptor type 2

Position

18p11.3-p11.2

Gene Type

protein-coding

Gene Regulation:

Transcription Factors
Post Transcriptional Modification From dbPTM
Methylation Profile From DiseaseMeth database

Transcription Factors

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Regulation From TransFac database

TC-PTPb(h) + importin-beta1(h) <==> TC-PTPb(h):importin-beta1(h) (binding)
PTPN2(h) --> TC-PTPb(h) (expression).
TC-PTPa(h) + importin-beta1(h) <==> TC-PTPa(h):importin-beta1(h) (binding)
PTPN2(h) --> TC-PTPa(h) (expression).
Shc-1-p52(h){p} --TC-PTPa(h)--> Shc-1-p52(h) + p (dephosphorylation)
14-3-3sigma(m.s.) + TC-PTP(h) <==> 14-3-3sigma(m.s.):TC-PTP(h) (binding)
PTPN2(h) --> TC-PTP(h) (expression).
STAT1(h){pY701} --TC-PTP(h)--> STAT1(h) + p (dephosphorylation)

Post Transcriptional Modification From dbPTM

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There is no record for PTPN2

Methylation Profile From DiseaseMeth database

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Chromosome

Location

Source

chr18

Promoter: 12873834 - 12875834Agilent_014791

chr18

Promoter: 12873834 - 12875834GSE27584

chr18

Promoter: 12873834 - 12875834GSE27584

chr18

Promoter: 12873834 - 12875834GSE27584

chr18

Promoter: 12873834 - 12875834Agilent_014791_44K


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