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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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Gene ID | 5771 |
Name | PTPN2 |
Synonym | PTN2|PTPT|TC-PTP|TCELLPTP|TCPTP;protein tyrosine phosphatase, non-receptor type 2;PTPN2;protein tyrosine phosphatase, non-receptor type 2 |
Definition | T-cell protein tyrosine phosphatase|tyrosine-protein phosphatase non-receptor type 2 |
Position | 18p11.3-p11.2 |
Gene Type | protein-coding |
Source | Count: 1; Generif |
Literature support | Count: 1 PubMed records as below. |
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Evidence Status |
Description |
potential | Our study provides genetic and functional evidence for a tumor suppressor role of PTPN2 and suggests that expression of PTPN2 may modulate response to treatment. |
| More detail of all 1 literatures about PTPN2 | |
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Pathways and Diseases |
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Pathway | PDGFR-beta signaling pathway;PID Curated;200127 |
Pathway | Signaling events mediated by TCPTP;PID Curated;200065 |
Pathway | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met);PID Curated;200032 |
Pathway | IFN-gamma pathway;PID Curated;200110 |
Disease | IMMUNE;GAD |
Disease | Metabolic diseases;KEGG DISEASE |
Disease | Type 1 diabetes;NHGRI |
Disease | Celiac disease;NHGRI |
Disease | type 1 diabetes;GAD |
Disease | Type I diabetes mellitus;KEGG DISEASE;H00408 |
Disease | Celiac Disease;GAD |
Disease | Crohn's;GAD |
Disease | Crohn's disease;GAD |
Disease | Crohn's disease;NHGRI |
Disease | Diabetes;KEGG DISEASE |
Disease | Ulcerative colitis;FunDO |
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External Links |
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Links to Entrez Gene | 5771 |
Links to all GeneRIF Items | 5771 |
Links to iHOP | 5771 |
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Sequence Information |
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Nucleotide Sequence |
>5771 : length: 1248 atgcccaccaccatcgagcgggagttcgaagagttggatactcagcgtcgctggcagccg ctgtacttggaaattcgaaatgagtcccatgactatcctcatagagtggccaagtttcca gaaaacagaaatcgaaacagatacagagatgtaagcccatatgatcacagtcgtgttaaa ctgcaaaatgctgagaatgattatattaatgccagtttagttgacatagaagaggcacaa aggagttacatcttaacacagggtccacttcctaacacatgctgccatttctggcttatg gtttggcagcagaagaccaaagcagttgtcatgctgaaccgcattgtggagaaagaatcg gttaaatgtgcacagtactggccaacagatgaccaagagatgctgtttaaagaaacagga ttcagtgtgaagctcttgtcagaagatgtgaagtcgtattatacagtacatctactacaa ttagaaaatatcaatagtggtgaaaccagaacaatatctcactttcattatactacctgg ccagattttggagtccctgaatcaccagcttcatttctcaatttcttgtttaaagtgaga gaatctggctccttgaaccctgaccatgggcctgcggtgatccactgtagtgcaggcatt gggcgctctggcaccttctctctggtagacacttgtcttgttttgatggaaaaaggagat gatattaacataaaacaagtgttactgaacatgagaaaataccgaatgggtcttattcag accccagatcaactgagattctcatacatggctataatagaaggagcaaaatgtataaag ggagattctagtatacagaaacgatggaaagaactttctaaggaagacttatctcctgcc tttgatcattcaccaaacaaaataatgactgaaaaatacaatgggaacagaataggtcta gaagaagaaaaactgacaggtgaccgatgtacaggactttcctctaaaatgcaagataca atggaggagaacagtgagagtgctctacggaaacgtattcgagaggacagaaaggccacc acagctcagaaggtgcagcagatgaaacagaggctaaatgagaatgaacgaaaaagaaaa aggtggttatattggcaacctattctcactaagatggggtttatgtcagtcattttggtt ggcgcttttgttggctggagactgttttttcagcaaaatgccctataa |
Protein Sequence |
>5771 : length: 415 MPTTIEREFEELDTQRRWQPLYLEIRNESHDYPHRVAKFPENRNRNRYRDVSPYDHSRVK LQNAENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKES VKCAQYWPTDDQEMLFKETGFSVKLLSEDVKSYYTVHLLQLENINSGETRTISHFHYTTW PDFGVPESPASFLNFLFKVRESGSLNPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGD DINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIEGAKCIKGDSSIQKRWKELSKEDLSPA FDHSPNKIMTEKYNGNRIGLEEEKLTGDRCTGLSSKMQDTMEENSESALRKRIREDRKAT TAQKVQQMKQRLNENERKRKRWLYWQPILTKMGFMSVILVGAFVGWRLFFQQNAL |