Entrez Gene

General information | Expression | Regulation | Mutation | Interaction

Basic Information
Gene ID	5771
Name	PTPN2
Synonymous	PTN2\|PTPT\|TC-PTP\|TCELLPTP\|TCPTP;protein tyrosine phosphatase, non-receptor type 2;PTPN2;protein tyrosine phosphatase, non-receptor type 2
Definition	T-cell protein tyrosine phosphatase\|tyrosine-protein phosphatase non-receptor type 2
Position	18p11.3-p11.2
Gene type	protein-coding
Source	Count: 1; Generif
Sentence	Abstract
Our study provides genetic and functional evidence for a tumor suppressor role of PTPN2 and suggests that expression of PTPN2 may modulate response to treatment.	PTPN2 (protein tyrosine phosphatase non-receptor type 2, also known as TC-PTP) is a cytosolic tyrosine phosphatase that functions as a negative regulator of a variety of tyrosine kinases and other signaling proteins. In agreement with its role in the regulation of the immune system, PTPN2 was identified as a susceptibility locus for autoimmune diseases. In this work, we describe the identification of focal deletions of PTPN2 in human T-cell acute lymphoblastic leukemia (T-ALL). Deletion of PTPN2 was specifically found in T-ALLs with aberrant expression of the TLX1 transcription factor oncogene, including four cases also expressing the NUP214-ABL1 tyrosine kinase. Knockdown of PTPN2 increased the proliferation and cytokine sensitivity of T-ALL cells. In addition, PTPN2 was identified as a negative regulator of NUP214-ABL1 kinase activity. Our study provides genetic and functional evidence for a tumor suppressor role of PTPN2 and suggests that expression of PTPN2 may modulate response to treatment.