Basic Information
Gene ID	5782
Name	PTPN12
Synonymous	PTP-PEST\|PTPG1;protein tyrosine phosphatase, non-receptor type 12;PTPN12;protein tyrosine phosphatase, non-receptor type 12
Definition	protein-tyrosine phosphatase G1\|tyrosine-protein phosphatase non-receptor type 12
Position	7q11.23
Gene Type	protein-coding
Gene Regulation:	Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database

Transcription Factors

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Regulation From TransFac database
PTP-PEST(h) + 2 ATP --PKC(r)--> PTP-PEST(h){pS39}{pS439} + 2 ADP (phosphorylation)
PTP-PEST(h) + 2 ATP --PKAc(m)--> PTP-PEST(h){pS39}{pS439} + 2 ADP (phosphorylation)
PTP-PEST(h) + Shc-1(h) <==> PTP-PEST(h):Shc-1(h) (binding)
PSTPIP1(h) + PTP-PEST(h) <==> PSTPIP1(h):PTP-PEST(h) (binding)
WASP(h) + PTP-PEST(h) <==> WASP(h):PTP-PEST(h) (binding)
PTP-PEST(h) + Csk(h) <==> PTP-PEST(h):Csk(h) (binding)
PTPN12(h) --> PTP-PEST(h) (expression).
Pyk2(r){pY402}{pY579}{pY580} --PTP-PEST(h)--> Pyk2(r) + 3 p (dephosphorylation)
Cas(h){p} --PTP-PEST(h)--> Cas(h) + p (dephosphorylation)
Cas(mo){p} --PTP-PEST(h)--> Cas(mo) + p (dephosphorylation)
Cas(r){pY} --PTP-PEST(h)--> Cas(r) + p (dephosphorylation)
PTPN12(h) --> PTP-PEST(h) (expression).

Location (AA)	PTM type	Literature	Database
1	N-acetylmethionine.		Swiss-Prot 53.0
332	Phosphoserine.		Swiss-Prot 53.0
596	Phosphoserine (By similarity).		Swiss-Prot 53.0
598	Phosphothreonine (By similarity).		Swiss-Prot 53.0
603	Phosphoserine.		Swiss-Prot 53.0
606	Phosphoserine.		Swiss-Prot 53.0
608	Phosphoserine (By similarity).		Swiss-Prot 53.0
673	Phosphoserine.		Swiss-Prot 53.0
435	Phosphoserine (PKC alpha;PK)	94349924;7520867	Phospho.ELM 6.0
39	Phosphoserine (PKC alpha;PK)	94349924;7520867	Phospho.ELM 6.0
332	Phosphoserine	17081983	Phospho.ELM 6.0
603	Phosphoserine	17081983	Phospho.ELM 6.0
606	Phosphoserine	17081983	Phospho.ELM 6.0
608	Phosphoserine	17081983	Phospho.ELM 6.0