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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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Gene ID | 6934 |
Name | TCF7L2 |
Synonymous | TCF-4|TCF4;transcription factor 7-like 2 (T-cell specific, HMG-box);TCF7L2;transcription factor 7-like 2 (T-cell specific, HMG-box) |
Definition | HMG box transcription factor 4|T-cell factor 4|T-cell factor-4 variant A|T-cell factor-4 variant B|T-cell factor-4 variant C|T-cell factor-4 variant D|T-cell factor-4 variant E|T-cell factor-4 variant F|T-cell factor-4 variant G|T-cell factor-4 variant H| |
Position | 10q25.3 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors | | Top | |
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Regulation From TransFac database |
TCF-4E(h) --> CCND1(h) (DNA binding). | TCF-4E(h) + beta-catenin(h) <==> TCF-4E(h):beta-catenin(h) (binding). | TCF7L2(h) --> TCF-4E(h) (expression). | TCF-4B(h) + beta-catenin(h) <==> TCF-4B(h):beta-catenin(h) (binding). | TCF7L2(h) --> TCF-4B(h) (expression). | TCF-4(h) --> TCF7(h) (DNA binding). | TCF-4(h) --> MMP7(h) (DNA binding; transregulation). | TCF-4(h) --> c-myc(h) (DNA binding; transregulation). | TCF-4(h) --> FOSL1(h) (DNA binding). | TCF-4(h) + beta-catenin(h) <==> TCF-4(h):beta-catenin(h) (binding) | CtBP1(m) + TCF-4(h) <==> CtBP1(m):TCF-4(h) (binding) | CtBP1(h) + TCF-4(h) <==> CtBP1(h):TCF-4(h) (binding) | TCF-4(h) + CtBP2(m) <==> CtBP2(m):TCF-4(h) (binding) | Grg-1(m) + TCF-4(h) <==> Grg-1(m):TCF-4(h) (binding) | ESG3(m) + TCF-4(h) <==> ESG3(m):TCF-4(h) (binding) | Grg4(m) + TCF-4(h) <==> Grg4(m):TCF-4(h) (binding) | TCF-4(h) + TLE-2(h) <==> TCF-4(h):TLE-2(h) (binding) | TCF-4(h) + ATP --NLK(m)--> TCF-4(h){pT178}{pT189} + ADP (phosphorylation) | TCF-4(h) + NLK(m) <==> NLK(m):TCF-4(h) (binding) | beta-catenin(h) + TCF-4(h) + NLK(m) <==> beta-catenin(h):TCF-4(h):NLK(m) (binding) | beta-catenin(m) + TCF-4(h) <==> beta-catenin(m):TCF-4(h) (binding) | beta-catenin(ca) + TCF-4(h) <==> beta-catenin(ca):TCF-4(h) (binding) | plakoglobin(h) + TCF-4(h) <==> plakoglobin(h):TCF-4(h) (binding) | beta-catenin(h) + plakoglobin(h) + TCF-4(h) <==> beta-catenin(h):TCF-4(h):plakoglobin(h) (binding) | TCF-4(h) + ATP --CKII-alpha(r):CKII-alpha2(r):(CKII-beta(r))2--> TCF-4(h){pS60} + ADP (phosphorylation) | TCF-4(h) + Smad3(h) <==> TCF-4(h):Smad3(h) (binding) | TCF-4(h) + Smad4(h) <==> TCF-4(h):Smad4(h) (binding) | TCF-4(h) + beta-catenin(h) <==> TCF-4(h):beta-catenin(h) (binding) | TCF-4(h) + beta-catenin(h) + HIC-1(h) <==> TCF-4(h):beta-catenin(h):HIC-1(h) (binding) | TCF-4(h) + PARP(h) <==> TCF-4(h):PARP(h) (binding) | TCF-4(h) + Ku70(h) <==> TCF-4(h):Ku70(h) (binding) | TCF-4(h) + Ku80(h) <==> TCF-4(h):Ku80(h) (binding) | Ku70(m) + TCF-4(h) <==> Ku70(m):TCF-4(h) (binding) | TCF-4(h) + PARP(h) <==> TCF-4(h):PARP(h) (binding) | TCF-4(h) --> NOS2(h) (DNA binding). | TCF-4(h) --> CSPG2(h) (DNA binding; transactivation). | TCF-4(h) --> CCND1(h) (transactivation) | TCF-4(h) + NLK(m.s.) <==> TCF-4(h):NLK(m.s.) (binding) | TCF-4(h) + NLK(m.s.) + beta-catenin(m.s.) <==> TCF-4(h):NLK(m.s.):beta-catenin(m.s.) (binding) | TCF-4(h) + 2 ATP --NLK(m.s.)--> TCF-4(h){pT178}{pT189} + 2 ADP (phosphorylation) | beta-catenin(m.s.) + TCF-4(h) <==> beta-catenin(m.s.):TCF-4(h) (binding) | TCF-4(h) --> ABCB1(h) (transactivation) | Sox17(m) + TCF-4(h) <==> Sox17(m):TCF-4(h) (binding) | TCF-4(h) + Sox17(m) + beta-catenin(h) <==> TCF-4(h):Sox17(m):beta-catenin(h) (binding) | TCF-4(h) + Sox4(m) <==> TCF-4(h):Sox4(m) (binding) | TCF7L2(h) --> TCF-4(h) (expression). | TCF7L2(h) --> TCF-4(K)(h) (expression). | TCF7L2(h) --> TCF-4-isoform1(h) (expression). | TCF7L2(h) --> TCF-4-isoform2(h) (expression). | TCF7L2(h) --> TCF-4-isoform3(h) (expression). | TCF7L2(h) --> TCF-4-isoform4(h) (expression). | TCF7L2(h) --> TCF-4-isoform5(h) (expression). | TCF7L2(h) --> TCF-4-isoform6(h) (expression). | TCF7L2(h) --> TCF-4-isoform7(h) (expression). | HIC-1-isoform2(h) + TCF-4-isoform8(h) <==> HIC-1-isoform2(h):TCF-4-isoform8(h) (binding) | TCF7L2(h) --> TCF-4-isoform8(h) (expression). | TCF7L2(h) --> TCF-4-isoform9(h) (expression). | TCF7L2(h) --> TCF-4-isoform10(h) (expression). |
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Post Transcriptional Modification From dbPTM | | Top | |
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Location (AA) |
PTM type |
Literature |
Database |
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Methylation Profile From DiseaseMeth database | | Top | |
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Chromosome |
Location |
Source |
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chr10 |
Promoter: 114698701 - 114700701 | GoldenGate_Methylation_Cancer_Panel_I |
chr10 |
Promoter: 114698701 - 114700701 | GSE27584 |
chr10 |
Promoter: 114698701 - 114700701 | Agilent_014791_44K |
chr10 |
Promoter: 114698701 - 114700701 | Agilent_014791 |