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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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Gene ID | 7040 |
Name | TGFB1 |
Synonymous | CED|DPD1|LAP|TGFB|TGFbeta;transforming growth factor, beta 1;TGFB1;transforming growth factor, beta 1 |
Definition | TGF-beta 1 protein|TGF-beta-1|latency-associated peptide|transforming growth factor beta-1 |
Position | 19q13.2|19q13.1 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors | | Top | |
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Regulation From TransFac database |
TGFbeta1(h) + TGFbetaR-II(h) + TGFbetaR-I(h) <==> TGFbeta1(h):TGFbetaR-II(h):TGFbetaR-I(h) (binding) | TGFbeta1(h) --> Smad2-L(h) (activation; phosphorylation) | TGFbeta1(h) --> Smad2(mo) (activation; phosphorylation) | TGFbeta1(h) + TGFbetaR-II(pg) + TGFbetaR-I(h) <==> TGFbeta1(h):TGFbetaR-II(pg):TGFbetaR-I(h) (binding) | TGFbeta1(h) + LAP(h) <==> TGFbeta1(h):LAP(h) (binding) | TGFbeta1(h) + TGFbetaR-II(mv) + TGFbetaR-I(mv) <==> TGFbeta1(h):TGFbetaR-II(mv):TGFbetaR-I(mv) (binding) | TGFbeta1(h) + TGFbetaR-II(pg) + TGFbetaR-I(pg) <==> TGFbeta1(h):TGFbetaR-II(pg):TGFbetaR-I(pg) (binding) | TGFbeta1(h) + TGFbetaR-III(h) + TGFbetaR-II(h) <==> TGFbeta1(h):TGFbetaR-III(h):TGFbetaR-II(h) (binding) | TGFbeta1(h) + LAP1(h) + beta1-integrin(h) <==> TGFbeta1(h):LAP1(h):beta1-integrin(h) (binding) | heparin + TGFbeta1(h) <==> heparin:TGFbeta1(h) (binding) | HSPGs(r) + TGFbeta1(h) <==> HSPGs(r):TGFbeta1(h) (binding) | TGFbeta1(h) + TGFbetaR-II(h) <==> TGFbeta1(h):TGFbetaR-II(h) (binding) | LAP1(h) + TGFbeta1(h) <==> LAP1(h):TGFbeta1(h) (binding) | TGFbeta1(h) + TGFbetaR-III(h) <==> TGFbeta1(h):TGFbetaR-III(h) (binding) | TGFbeta1(h) --> Fos(r) (transactivation) | TGFbeta1(h) --> S100A11(h) (transactivation) | TGFbeta1(h) --> CDKN1A(h) (transactivation) | TGFbeta1(h) --> ERK(m){p} (increase of phosphorylation) | TGFbeta1(h) --> RSK1(m){p} (increase of phosphorylation) | TGFbeta1(h) --> bad(m){pS112} (increase of phosphorylation) | TGFbeta1(h) --/ bad(m) (decrease of abundance) | TGFbeta1(h) --> FLT3(h) (decrease of abundance) | TGFbeta1(h) --> Dab2(m):TAK1(m) (increase of binding) | TGFbeta1(h) --/ E-cadherin(m) (decrease of abundance) | TGFbeta1(h) --/ beta-catenin(m) (decrease of abundance) | TGFB1(h) --> TGFbeta1(h) (expression). | IGFBP-2(h) --> TGFbeta1(h) (increase of abundance) | IL-1beta(h) --> TGFbeta1(h) (increase of secretion) | TNF-alpha(h) --> TGFbeta1(h) (increase of secretion) | IFNgamma(h) --> TGFbeta1(h) (increase of secretion) | TGFbeta1(h) --PACE(r)--> TGFbeta1-CTF(h) + LAP1(h) (cleavage) | TGFbeta1(h) --> p21Cip1(h) (increase of abundance) | TGFbeta1(h) --> c-Jun(h) (increase of abundance) | TGFbeta1(h) --> Smad2(h){p} (increase of phosphorylation) | TGFbeta1(h) --/ Cdc25A(h) (decrease of abundance) | TGFbeta1(h) --/ cdc25A(h) (transrepression) | TGFbeta1(h) --> Cdc25a(h){ub(n)} (increase of ubiquitination) | TGFbeta1(h) --> Cdc25A(h){pS82}{pS88} (increase of phosphorylation) | TGFbeta1(h) --> COL1A1(h) (transactivation) | TGFbeta1(h) --> COL1A2(h) (transactivation) | TGFbeta1(h) --> CTGF(h) (transactivation) | TGFbeta1(h) --> TIMP-1(h) (transactivation) | TGFbeta1(h) --/ MMP1(h) (transrepression) | TGFbeta1(h) --> fibronectin(h) (increase of abundance) | TGFbeta1(h) --> c-Ets-1(h){aceK} (increase of acetylation) | TGFbeta1(h) --> c-Ets-1(m.s.){aceK} (increase of acetylation) | TGFbeta1(h) --> Smad2(h){pS} (increase of phosphorylation) | TGFbeta1(h) --> Smad3(h){pS} (increase of phosphorylation) | TGFbeta1(h) --> collagen-I(h) (increase of abundance) | TGFbeta1(h) --> collagen-III(h) (increase of abundance) | TGFbeta1(h) --> c-Ets-1(h){aceK}:p300(h) (increase of abundance) | TGFbeta1(h) --> p300(h):Smad3(h) (increase of abundance) | TGFbeta1(h) --> PIAS4(h) (transactivation) | TGFbeta1(h) --> SERPINE1(h) (transactivation) | TGFbeta1(h) --> alpha-actin-2(h) (increase of abundance) | TGFbeta1(h) --> alpha-actin-2(r) (increase of abundance) | TGFbeta1(h) --> Smad2(r){p} (increase of phosphorylation) | TGFbeta1(h) --> Smad4(r):TGIF(r) (increase of binding) | TGFbeta1(h) --/ SP-B(h) (transrepression) | TGFbeta1(h) --> Smad2(h){aceK} (increase of acetylation) | TGFbeta1(h) --> pRb(h){p} (decrease of phosphorylation) | TGFbeta1(h) --> CDKN2B(h) (transactivation) | TGFbeta1(h) --> p27Kip1(h) (increase of abundance) | TGFbeta1(h) --> p15INK4b(r) (increase of abundance) | TGFbeta1(h) --> p15INK4b(h) (increase of abundance) | TGFbeta1(h) --/ Cdk2(r) (decrease of abundance) | TGFbeta1(h) --/ Cdk2(h) (decrease of abundance) | TGFbeta1(h) --> pRb(r){p} (decrease of phosphorylation) | TGFbeta1(h) --> VEGFA(h) (transactivation) | TGFbeta1(h) --/ cyclinD1(m) (decrease of abundance) | TGFbeta1(h) --> CBP(m.s.):STAT5(m.s.) (decrease of binding) | TGFbeta1(h) --> SMAD7(r) (transactivation) | TGFbeta1(h) --> IL-11(h) (increase of secretion) | TGFbeta1(h) --> IL11(h) (transactivation) | TGFbeta1(h) --/ PTEN(m) (decrease of abundance) | TGFbeta1(h) --> AKT-1(m){pS473} (increase of phosphorylation) | TGFbeta1(h) --/ Tyrp1(m) (decrease of abundance) | TGFbeta1(h) --/ tyrosinase(m) (decrease of abundance) | TGFbeta1(h) --/ Tyr(m) (transrepression) | TGFbeta1(h) --> SNA(m) (increase of abundance) | TGFbeta1(h) --/ E-cadherin(m) (decrease of abundance) | TGFB1(h) --> TGFbeta1(h) (expression). |
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Post Transcriptional Modification From dbPTM | | Top | |
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Location (AA) |
PTM type |
Literature |
Database |
82 | N-linked (GlcNAc...). | Swiss-Prot 53.0 | 136 | N-linked (GlcNAc...) (By similarity). | Swiss-Prot 53.0 | 176 | N-linked (GlcNAc...) (By similarity). | Swiss-Prot 53.0 |
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Methylation Profile From DiseaseMeth database | | Top | |
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Chromosome |
Location |
Source |
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chr19 |
Promoter: 46551156 - 46553156 | Agilent_014791 |
chr19 |
Promoter: 46551156 - 46553156 | GoldenGate_Methylation_Cancer_Panel_I |
chr19 |
Promoter: 46551156 - 46553156 | GSE27584 |
chr19 |
Promoter: 46551156 - 46553156 | Agilent_014791_44K |