Bioinformatics and Systems Medicine Laboratory
General information | Expression | Regulation | Mutation | Interaction

Basic Information

Gene ID

7161

Name

TP73

Synonymous

P73;tumor protein p73;TP73;tumor protein p73

Definition

p53-like transcription factor|p53-related protein

Position

1p36.3

Gene Type

protein-coding

Gene Regulation:

Transcription Factors
Post Transcriptional Modification From dbPTM
Methylation Profile From DiseaseMeth database

Transcription Factors

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Regulation From TransFac database

4 p73(h) <==> (p73(h))4 (binding)
p63(h) + p73(h) <==> p63(h):p73(h) (binding)
WOX1(h) + p73(h) <==> WOX1(h):p73(h) (binding)
p73(h) + Pin1(h) <==> p73(h):Pin1(h) (binding)
p73(h) + Abl(h) <==> p73(h):Abl(h) (binding)
itch(h) + p73(h) <==> itch(h):p73(h) (binding)
p73(h) + ATP --> p73(h){pY} + ADP (phosphorylation)
p73(h) + Nedd8(h) --> p73(h){nedd} (neddylation)
IKK-alpha(h) + p73(h) <==> IKK-alpha(h):p73(h) (binding)
Hck(h) + p73(h) <==> Hck(h):p73(h) (binding)
TP73(h) --> p73(h) (expression).
amphiphysin2b-1(h) + p73beta(h) <==> amphiphysin2b-1(h):p73beta(h) (binding)
p73beta(h) --> CDKN1A(h) (transactivation)
p73beta(h) + ATP --Chk1(h){p}--> p73beta(h){p} + ADP (phosphorylation)
Chk1(h) + p73beta(h) <==> Chk1(h):p73beta(h) (binding)
Daxx(h) + p73beta(h) <==> Daxx(h):p73beta(h) (binding)
p73beta(h) + hipk2(h) <==> p73beta(h):hipk2(h) (binding)
p73beta(h) + hipk2(ha) <==> p73beta(h):hipk2(ha) (binding)
2 p73beta(h) <==> (p73beta(h))2 (binding)
Cdk1(h) + p73beta(h) <==> Cdk1(h):p73beta(h) (binding)
p73beta(h) + ATP --cyclinA(v.s.):Cdk2(v.s.)--> p73beta(h){p} + ADP (phosphorylation)
p73beta(h) + ATP --cyclinE(v.s.):Cdk2(v.s.)--> p73beta(h){p} + ADP (phosphorylation)
p73beta(h) + cyclinA(v.s.) <==> p73beta(h):cyclinA(v.s.) (binding)
p73beta(h) + cyclinE(v.s.) <==> p73beta(h):cyclinE(v.s.) (binding)
p73beta(h) + cyclinB(v.s.) <==> p73beta(h):cyclinB(v.s.) (binding)
p73beta(h) + cyclinD(v.s.) <==> p73beta(h):cyclinD(v.s.) (binding)
p73beta(h) + ATP --cyclinA(v.s.):Cdk1(v.s.)--> p73beta(h){p} + ADP (phosphorylation)
p73beta(h) + ATP --cyclinB(v.s.):Cdk1(v.s.)--> p73beta(h){p} + ADP (phosphorylation)
p73beta(h) + ATP --cyclinB(v.s.):Cdk2(v.s.)--> p73beta(h){p} + ADP (phosphorylation)
p73beta(h) + ATP --cyclinA(v.s.):Cdk2(v.s.)--> p73beta(h){pT86} + ADP (phosphorylation)
p73beta(h) + ATP --cyclinB(v.s.):Cdk2(v.s.)--> p73beta(h){pT86} + ADP (phosphorylation)
p73beta(h) + Pin1(h) <==> p73beta(h):Pin1(h) (binding)
p73beta(h) + PKCdelta(h) <==> p73beta(h):PKCdelta(h) (binding)
p73beta(h) + PKCdelta-CF(h) <==> p73beta(h):PKCdelta-CF(h) (binding)
p73beta(h) + PKCdelta(v.s.) <==> p73beta(h):PKCdelta(v.s.) (binding)
p73beta(h) + PKCdelta-CF(v.s.) <==> p73beta(h):PKCdelta-CF(v.s.) (binding)
p73beta(h) + ATP --PKCdelta-CF(v.s.)--> p73beta(h){pS289} + ADP (phosphorylation)
WOX1(h) + p73beta(h) <==> WOX1(h):p73beta(h) (binding)
WOX1(h){pY33} + p73beta(h) <==> WOX1(h){pY33}:p73beta(h) (binding)
p73beta(h) --> MDM2(h) (transactivation)
p73beta(h) --> CDKN1C(m) (transactivation)
p73beta(h) --> CDKN1C(h) (transactivation)
p73beta(h) --> KCNQ1(h) (transactivation)
HMGB1(h) + p73beta(h) <==> HMGB1(h):p73beta(h) (binding; interaction)
p73beta(h) + p/CAF(h) <==> p73beta(h):p/CAF(h) (binding; interaction)
p73beta(h) --> BAX(h) (transactivation)
p73beta(h) --> GADD45A(h) (transactivation)
p73beta(h) --> IGFBP3(h) (transactivation)
p73beta(h) --> RRM2B(h) (transactivation)
p73beta(h) --> ADA(h) (DNA binding; transactivation).
p73beta(h) --> TP73(h) (DNA binding; transactivation).
p73beta(h) + Smad2(m.s.) <==> p73beta(h):Smad2(m.s.) (binding)
p73beta(h) + Smad3(m.s.) <==> p73beta(h):Smad3(m.s.) (binding)
p73beta(h) + HCV-Core-1A(HCV1A) <==> p73beta(h):HCV-Core-1A(HCV1A) (binding)
PKAc-beta(m.s.) + p73beta(h) <==> PKAc-beta(m.s.):p73beta(h) (binding)
p73beta(h) --> DRAM(h) (transactivation)
TP73(h) --> p73beta(h) (expression).
Chk1(h) + p73alpha(h) <==> Chk1(h):p73alpha(h) (binding)
p73alpha(h) + ATP --Chk1(h){p}--> p73alpha(h){p} + ADP (phosphorylation)
p73alpha(h) + ATP --Chk1(h)--> p73alpha(h){pS47} + ADP (phosphorylation)
Daxx(h) + p73alpha(h) <==> p73alpha(h):Daxx(h) (binding)
p73alpha(h) + hipk2(h) <==> p73alpha(h):hipk2(h) (binding)
p73alpha(h) + hipk2(ha) <==> p73alpha(h):hipk2(ha) (binding)
p73alpha(h) + SAE2(h) <==> p73alpha(h):SAE2(h) (binding)
p73alpha(h) + sumo1(h) --> p73alpha(h){sumo} (sumoylation)
p73alpha(h) + Ubc9(h) <==> p73alpha(h):Ubc9(h) (binding)
p73alpha(h) + Mi2-alpha(h) <==> p73alpha(h):Mi2-alpha(h) (binding)
p73alpha(h) + hipk3(h) <==> p73alpha(h):hipk3(h) (binding)
p73alpha(h) + sumo1(h) --> p73alpha(h){sumoK627} (sumoylation)
p73alpha(h) + SSRP1(h) <==> p73alpha(h):SSRP1(h) (binding)
p73alpha(h) + p300(h) <==> p73alpha(h):p300(h) (binding)
PC + p73alpha(h) <==> PC:p73alpha(h) (binding)
PA + p73alpha(h) <==> PA:p73alpha(h) (binding)
Abl(h) + p73alpha(h) <==> Abl(h):p73alpha(h) (binding)
cyclinB1(h):Cdk1(h) + p73alpha(h) <==> cyclinB1(h):Cdk1(h):p73alpha(h) (binding)
p73alpha(h) + ATP --cyclinA(v.s.):Cdk2(v.s.)--> p73alpha(h){p} + ADP (phosphorylation)
p73alpha(h) + acetyl-CoA --p300(h)--> p73alpha(h){ace} + CoA (acetylation)
p73alpha(h) + ATP --Abl(h)--> p73alpha(h){p} + ADP (phosphorylation)
WOX1(h) + p73alpha(h) <==> WOX1(h):p73alpha(h) (binding)
p73alpha(h) --/ Pdgfrb(m) (transrepression)
NF-YB(m) + p73alpha(h) <==> NF-YB(m):p73alpha(h) (binding; interaction)
NF-YC-3(h) + p73alpha(h) <==> NF-YC-3(h):p73alpha(h) (binding; interaction)
c-Myc(h) + p73alpha(h) <==> c-Myc(h):p73alpha(h) (binding; interaction)
HMGB1(h) + p73alpha(h) <==> HMGB1(h):p73alpha(h) (binding; interaction)
CTF-2(h) + p73alpha(h) <==> CTF-2(h):p73alpha(h) (binding; interaction)
p73alpha(h) + p/CAF(h) <==> p73alpha(h):p/CAF(h) (binding; interaction)
p73alpha(h) --> CDKN1A(h) (transactivation)
p73alpha(h) --> MDM2(h) (transactivation)
p73alpha(h) --> GADD45A(h) (transactivation)
p73alpha(h) --> IGFBP3(h) (transactivation)
p73alpha(h) --> RRM2B(h) (transactivation)
p73alpha(h) --> BAX(h) (DNA binding; transactivation).
p73alpha(h) --> ADA(h) (DNA binding; transactivation).
p73alpha(h) --> TP73(h) (DNA binding; transactivation).
ASPP1(h) + p73alpha(h) <==> ASPP1(h):p73alpha(h) (binding)
ASPP2(h) + p73alpha(h) <==> ASPP2(h):p73alpha(h) (binding)
p73alpha(h) + RanBPM(h) <==> p73alpha(h):RanBPM(h) (binding)
p73alpha(h) + PMS2(h) <==> p73alpha(h):PMS2(h) (binding)
PML(h) + p73alpha(h) <==> PML(h):p73alpha(h) (binding)
HDAC1(v.s.) + p73alpha(h) <==> HDAC1(v.s.):p73alpha(h) (binding)
Cables(v.s.) + p73alpha(h) <==> Cables(v.s.):p73alpha(h) (binding)
itch(h) + p73alpha(h) <==> itch(h):p73alpha(h) (binding)
ubiquitin(h) + p73alpha(h) --UbcH7(h),itch-xbb1(m)--> p73alpha(h){ub} (ubiquitination)
ubiquitin(h) + p73alpha(h) --itch(h)--> p73alpha(h){ub} (ubiquitination)
NEDD4-1(m.s.) + p73alpha(h) <==> NEDD4-1(m.s.):p73alpha(h) (binding)
PIAS1(h) + p73alpha(h) <==> PIAS1(h):p73alpha(h) (binding)
PIAS1(m.s.) + p73alpha(h) <==> PIAS1(m.s.):p73alpha(h) (binding)
p73alpha(h) + sumo1(h) --PIAS1(m.s.)--> p73alpha(h){sumo} (sumoylation)
p73alpha(h) --> p21Cip1(h) (increase of abundance)
HCV-Core-1A(HCV1A) + p73alpha(h) <==> HCV-Core-1A(HCV1A):p73alpha(h) (binding)
IKK-alpha(m.s.) + p73alpha(h) <==> IKK-alpha(m.s.):p73alpha(h) (binding)
p73alpha(h) + ATP --IKK-alpha(m.s.)--> p73alpha(h){p} + ADP (phosphorylation)
PKAc-beta(h) + p73alpha(h) <==> PKAc-beta(h):p73alpha(h) (binding)
PKAc-beta(m.s.) + p73alpha(h) <==> PKAc-beta(m.s.):p73alpha(h) (binding)
p73alpha(h) + PKAc-beta(mo) <==> p73alpha(h):PKAc-beta(mo) (binding)
p73alpha(h) + PKAc-alpha(mo) <==> p73alpha(h):PKAc-alpha(mo) (binding)
p73alpha(h) + ATP --PKAc(b)--> p73alpha(h){p} + ADP (phosphorylation)
Hck-p59(h) + p73alpha(h) <==> Hck-p59(h):p73alpha(h) (binding)
p73alpha(h) + ATP --Hck(h)--> p73alpha(h){p} + ADP (phosphorylation)
p73alpha(h) + ATP --> p73alpha(h){pY} + ADP (phosphorylation)
p73alpha(h) + ATP --Hck-p59(h)--> p73alpha(h){pY28} + ADP (phosphorylation)
p73alpha(h) + ATP --Src(h)--> p73alpha(h){pY28} + ADP (phosphorylation)
p73alpha(h) --> CARD12(h) (transactivation)
p73alpha(h) --> bbc3(h) (transactivation)
p73alpha(h) --> SFN(h) (transactivation)
p73alpha(h) --> DRAM(h) (transactivation)
p73alpha(h) + PIASy(h) <==> p73alpha(h):PIASy(h) (binding)
TP73(h) --> p73alpha(h) (expression).
p73gamma(h) + ATP --cyclinA(v.s.):Cdk2(v.s.)--> p73gamma(h){p} + ADP (phosphorylation)
p73gamma(h) --> RRM2B(h) (transactivation)
PIAS1(m.s.) + p73gamma(h) <==> PIAS1(m.s.):p73gamma(h) (binding)
p73gamma(h) + HCV-Core-1A(HCV1A) <==> p73gamma(h):HCV-Core-1A(HCV1A) (binding)
p73gamma(h) --> DRAM(h) (transactivation)
TP73(h) --> p73gamma(h) (expression).
p73delta(h) + HCV-Core-1A(HCV1A) <==> p73delta(h):HCV-Core-1A(HCV1A) (binding)
Hck-p59(h) + p73delta(h) <==> Hck-p59(h):p73delta(h) (binding)
TP73(h) --> p73delta(h) (expression).
TP73(h) --> p73epsilon(h) (expression).
DeltaNp73alpha(h) --> CDKN1A(h) (DNA binding).
PIAS1(m.s.) + DeltaNp73alpha(h) <==> PIAS1(m.s.):DeltaNp73alpha(h) (binding)
TP73(h) --> DeltaNp73alpha(h) (expression).
DeltaNp73beta(h) --> CDKN1A(h) (DNA binding).
TP73(h) --> DeltaNp73beta(h) (expression).
TP73(h) --> DeltaN p73gamma(h) (expression).
TP73(h) --> p73kappa(h) (expression).
TP73(h) --> p73zeta(h) (expression).
TP73(h) --> p73eta(h) (expression).

Post Transcriptional Modification From dbPTM

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Location (AA)

PTM type

Literature

Database

99Phosphotyrosine; by ABL; in isoform Beta.Swiss-Prot 53.0
627Glycyl lysine isopeptide (Lys-Gly)(interchain with G-Cter in SUMO) (inisoform Alpha).Swiss-Prot 53.0
99Phosphotyrosine (Abl)10391251Phospho.ELM 6.0
47Phosphoserine (CHK1)14585975Phospho.ELM 6.0
86Phosphothreonine (CDK2)12676926Phospho.ELM 6.0

Methylation Profile From DiseaseMeth database

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Chromosome

Location

Source

chr1

 Promoter: 3557489 - 3559489GoldenGate_Methylation_Cancer_Panel_I

chr1

 Promoter: 3557489 - 3559489GSE27584

chr1

 Promoter: 3557489 - 3559489Agilent_014791_44K

chr1

 Promoter: 3557489 - 3559489E-GEOD-20553

chr1

 Promoter: 3557489 - 3559489Agilent_014791

chr1

 Promoter: 3557489 - 3559489PMID:20064646

chr1

 Promoter: 3557489 - 3559489PMID:15367334

chr1

 Promoter: 3557489 - 3559489PMID:12579314

chr1

 Promoter: 3557489 - 3559489PMID:16983315

chr1

 Promoter: 3557489 - 3559489PMID:14654541

chr1

 Promoter: 3557489 - 3559489PMID:12200621

chr1

 Promoter: 3557489 - 3559489PMID:11487055

chr1

 Promoter: 3557489 - 3559489PMID:17216555

chr1

 Promoter: 3557489 - 3559489PMID:16391867

chr1

 Promoter: 3557489 - 3559489PMID:15365725

chr1

 Promoter: 3557489 - 3559489PMID:16051033

chr1

 Promoter: 3557489 - 3559489PMID:15198948

chr1

 Promoter: 3557489 - 3559489PMID:10416592

chr1

 Promoter: 3557489 - 3559489PMID:16192589

chr1

 Promoter: 3557489 - 3559489PMID:12114423

chr1

 Promoter: 3557489 - 3559489PMID:12548613

chr1

 Promoter: 3557489 - 3559489PMID:15495254

chr1

 Promoter: 3557489 - 3559489PMID:15897551

chr1

 Promoter: 3557489 - 3559489PMID:11786399

chr1

 Promoter: 3557489 - 3559489PMID:12660028

chr1

 Promoter: 3557489 - 3559489PMID:16858686

chr1

 Promoter: 3557489 - 3559489PMID:16537562

chr1

 Promoter: 3557489 - 3559489PMID:12584167

chr1

 Promoter: 3557489 - 3559489PMID:14501508

chr1

 Promoter: 3557489 - 3559489PMID:16166431

chr1

 Promoter: 3557489 - 3559489PMID:15526363

chr1

 Promoter: 3557489 - 3559489PMID:16764763

chr1

 Promoter: 3557489 - 3559489PMID:16412291

chr1

 Promoter: 3557489 - 3559489PMID:15467712

chr1

 Promoter: 3557489 - 3559489PMID:17058198

chr1

 Promoter: 3557489 - 3559489PMID:17369979

chr1

 Promoter: 3557489 - 3559489PMID:15197802

chr1

 Promoter: 3557489 - 3559489PMID:15318245

chr1

 Promoter: 3557489 - 3559489PMID:15173091

chr1

 Promoter: 3557489 - 3559489PMID:16785414

chr1

 Promoter: 3557489 - 3559489PMID:12826052

chr1

 Promoter: 3557489 - 3559489PMID:12632081

chr1

 Promoter: 3557489 - 3559489PMID:15154012

chr1

 Promoter: 3557489 - 3559489PMID:14527906

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