Basic Information
Gene ID	7248
Name	TSC1
Synonymous	LAM\|TSC;tuberous sclerosis 1;TSC1;tuberous sclerosis 1
Definition	hamartin\|tuberous sclerosis 1 protein\|tumor suppressor
Position	9q34
Gene Type	protein-coding
Gene Regulation:	Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database

Transcription Factors

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Regulation From TransFac database
tuberin(r) + hamartin(h) <==> tuberin(r):hamartin(h) (binding)
14-3-3zeta(h):tuberin(h) + hamartin(h) <==> 14-3-3zeta(h):tuberin(h):hamartin(h) (binding)
14-3-3beta(h) + tuberin(r) + hamartin(h) <==> 14-3-3beta(h):tuberin(r):hamartin(h) (binding)
hamartin(h) + radixin(h) <==> hamartin(h):radixin(h) (binding)
hamartin(h) + NFL(h) <==> hamartin(h):NFL(h) (binding)
tuberin(r) + hamartin(h) + GSK3beta(x) <==> tuberin(r):hamartin(h):GSK3beta(x) (binding)
tuberin(r) + hamartin(h) + axin(x) + GSK3beta(x) <==> tuberin(r):hamartin(h):axin(x):GSK3beta(x) (binding)
hamartin(h) + ATP --Cdk1(h)--> hamartin(h){pT417}{pS584}{pT1047} + ADP (phosphorylation)
hamartin(h) + ATP --cyclinB(h):Cdk1(x)--> hamartin(h){pT417}{pS584}{pT1047} + ADP (phosphorylation)
IKK-beta(h) + hamartin(h) <==> IKK-beta(h):hamartin(h) (binding)
hamartin(h) + ubiquitin(h) --> hamartin(h){ub} (ubiquitination)
hamartin(h) + tuberin(h) <==> hamartin(h):tuberin(h) (binding)
TSC1(h) --> hamartin(h) (expression).
cyclinD1(m.s.) + hamartin(h) <==> cyclinD1(m.s.):hamartin(h) (binding)
tuberin(r) + hamartin(h) <==> tuberin(r):hamartin(h) (binding)
hamartin(h) + 2 ATP --> hamartin(h){pS487}{pS511} + 2 ADP (phosphorylation)
TSC1(h) --> hamartin(h) (expression).
cyclinD1(m.s.) --/ hamartin(h) (decrease of abundance)

Location (AA)	PTM type	Literature	Database
505	Phosphoserine.		Swiss-Prot 53.0
417	Phosphothreonine (CDK1)	14551205	Phospho.ELM 6.0
1047	Phosphothreonine (CDK1)	14551205	Phospho.ELM 6.0
584	Phosphoserine (CDK1)	14551205	Phospho.ELM 6.0
505	Phosphoserine	15963462	Phospho.ELM 6.0