Bioinformatics and Systems Medicine Laboratory
General information | Expression | Regulation | Mutation | Interaction

Basic Information

Gene ID

8031

Name

NCOA4

Synonymous

ARA70|ELE1|PTC3|RFG;nuclear receptor coactivator 4;NCOA4;nuclear receptor coactivator 4

Definition

70 kDa AR-activator|70 kDa androgen receptor coactivator|NCoA-4|RET-activating gene ELE1|androgen receptor-associated protein of 70 kDa|ret fused

Position

10q11.2

Gene Type

protein-coding

Gene Regulation:

Transcription Factors
Post Transcriptional Modification From dbPTM
Methylation Profile From DiseaseMeth database

Transcription Factors

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Regulation From TransFac database

5alphaDHT:AR(h) + ARA70(h) <==> 5alphaDHT:AR(h):ARA70(h) (binding)
ARA70(h) + AR(h) <==> AR(h):ARA70(h) (binding)
NCOA4(h) --> ARA70(h) (expression).
AR(h) + ARA70-alpha(h) <==> AR(h):ARA70-alpha(h) (binding)
PPARgamma1(m) + ARA70-alpha(h) <==> PPARgamma1(m):ARA70-alpha(h) (binding)
RXR-alpha(h) + ARA70-alpha(h) <==> RXR-alpha(h):ARA70-alpha(h) (binding)
AR-isoform1(h) + ARA70-alpha(h) <==> AR-isoform1(h):ARA70-alpha(h) (binding)
ARA70-alpha(h) + p/CAF(m.s.) <==> ARA70-alpha(h):p/CAF(m.s.) (binding)
ER-alpha(m) + ARA70-alpha(h) <==> ER-alpha(m):ARA70-alpha(h) (binding)
GR(r) + ARA70-alpha(h) <==> GR(r):ARA70-alpha(h) (binding)
TFIIB(m.s.) + ARA70-alpha(h) <==> TFIIB(m.s.):ARA70-alpha(h) (binding)
NCOA4(h) --> ARA70-alpha(h) (expression).
AR-isoform1(h) + ARA70-beta(h) <==> AR-isoform1(h):ARA70-beta(h) (binding)
ER-alpha(m) + ARA70-beta(h) <==> ER-alpha(m):ARA70-beta(h) (binding)
GR(r) + ARA70-beta(h) <==> GR(r):ARA70-beta(h) (binding)
p/CAF(m.s.) + ARA70-beta(h) <==> p/CAF(m.s.):ARA70-beta(h) (binding)
TFIIB(m.s.) + ARA70-beta(h) <==> TFIIB(m.s.):ARA70-beta(h) (binding)
NCOA4(h) --> ARA70-beta(h) (expression).

Post Transcriptional Modification From dbPTM

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Location (AA)

PTM type

Literature

Database

456Phosphoserine.Swiss-Prot 53.0
456Phosphoserine17081983Phospho.ELM 6.0

Methylation Profile From DiseaseMeth database

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Chromosome

Location

Source

chr10

Promoter: 51240873 - 51242873Agilent_014791

chr10

Promoter: 51240873 - 51242873GSE27584

chr10

Promoter: 51240873 - 51242873Agilent_014791_44K


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