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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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Gene ID | 8772 |
Name | FADD |
Synonymous | MORT1;Fas (TNFRSF6)-associated via death domain;FADD;Fas (TNFRSF6)-associated via death domain |
Definition | Fas-associating death domain-containing protein|Fas-associating protein with death domain|growth-inhibiting gene 3 protein|mediator of receptor induced toxicity|mediator of receptor-induced toxicity|protein FADD |
Position | 11q13.3 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors | | Top | |
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Regulation From TransFac database |
Fas(h) + FADD(h) <==> Fas(h):FADD(h) (binding) | FADD(h) + proCaspase-8a(h) <==> FADD(h):proCaspase-8a(h) (binding) | FADD(h) + proCaspase-8d(h) <==> FADD(h):proCaspase-8d(h) (binding) | c-FLIP-S(h) + FADD(h) <==> c-FLIP-S(h):FADD(h) (binding) | c-FLIP-S(h) + FADD(h) + Fas(m) <==> c-FLIP-S(h):FADD(h):Fas(m) (binding) | c-FLIP-L(h) + FADD(h) + Fas(m) <==> c-FLIP-L(h):FADD(h):Fas(m) (binding) | c-FLIP-L-p43(h) + FADD(h) + Fas(h) + FasL(h) + proCaspase-8(h) <==> FasL(h):Fas(h):FADD(h):proCaspase-8(h):c-FLIP-L-p43(h) (binding) | Apo2L(h) + FADD(h) <==> Apo2L(h):FADD(h) (binding) | FasL(h) + FADD(h) <==> FasL(h):FADD(h) (binding) | FADD(h) + FAF1(h) <==> FADD(h):FAF1(h) (binding) | FADD(h) + DEDD(v.s.) <==> FADD(h):DEDD(v.s.) (binding) | DR5(h) + FADD(h) <==> DR5(h):FADD(h) (binding) | FADD(h) + TRADD(h) <==> FADD(h):TRADD(h) (binding) | FADD(h) + proCaspase-8(h) <==> FADD(h):proCaspase-8(h) (binding) | proCaspase-8(h) + Apo2L(h) + FADD(h) + DR5(h) <==> proCaspase-8(h):Apo2L(h):FADD(h):DR5(h) (binding) | proCaspase-10(h) + Apo2L(h) + FADD(h) + DR5(h) <==> proCaspase-10(h):Apo2L(h):FADD(h):DR5(h) (binding) | FADD(h) + FasL(h) + Fas(h) + proCaspase-10(h) <==> FADD(h):FasL(h):Fas(h):proCaspase-10(h) (binding) | FADD(h) + DEDD(m.s.) <==> FADD(h):DEDD(m.s.) (binding) | proCaspase-10(h) + FADD(h) + Fas(h) <==> proCaspase-10(h):FADD(h):Fas(h) (binding) | proCaspase-10(h) + DR5(h) + FADD(h) <==> proCaspase-10(h):DR5(h):FADD(h) (binding) | proCaspase-10(h) + DR4(m.s.) + FADD(h) <==> proCaspase-10(h):DR4(m.s.):FADD(h) (binding) | FADD(h) + FasL(h) + Fas(h) <==> FADD(h):FasL(h):Fas(h) (binding) | FADD(h) + ABC-1(h) <==> FADD(h):ABC-1(h) (binding) | FADD(h) + Fas(h) + c-FLIP-L-p43(h) <==> c-FLIP-L-p43(h):Fas(h):FADD(h) (binding) | FADD(h) + PKCzeta(h) <==> FADD(h):PKCzeta(h) (binding) | FADD(h) + ATP --PKCzeta(h)--> FADD(h){p} + ADP (phosphorylation) | FADD(h) + CKI-alpha(h) <==> FADD(h):CKI-alpha(h) (binding) | FADD(h) + ATP --CKI-alpha(h)--> FADD(h){pS194} + ADP (phosphorylation) | MBD4(h) + FADD(h) <==> MBD4(h):FADD(h) (binding) | FADD(h) --> FAF1(m.s.) (activation) | c-FLIP-L-p43(h) + FADD(h) + Fas(h) + proCaspase-10(h) <==> c-FLIP-L-p43(h):FADD(h):Fas(h):proCaspase-10(h) (binding) | c-FLIP-L-p43(h) + FADD(h) + Fas(h) + proCaspase-8(h) <==> c-FLIP-L-p43(h):FADD(h):Fas(h):proCaspase-8(h) (binding) | c-FLIP-L-p43(h) + FADD(h) + proCaspase-8(h) + Fas(h) <==> c-FLIP-L-p43(h):Fas(h):FADD(h):proCaspase-8(h) (binding) | Apo2L(m.s.) + FADD(h) + c-FLIP-L-p43(h) + Caspase-8-p18(h) + c-FLIP-S(h) <==> Apo2L(m.s.):FADD(h):c-FLIP-L-p43(h):Caspase-8-p18(h):c-FLIP-S(h) (binding) | Apo2L(h) + DR5(h) + FADD(h) + proCaspase-8(h) + c-FLIP-L(h) <==> Apo2L(h):DR5(h):FADD(h):proCaspase-8(h):c-FLIP-L(h) (binding) | Fas(h) + FasL(h) + c-FLIP-S(m.s.) + FADD(h) + proCaspase-8(h) + c-FLIP-L-p43(h) <==> Fas(h):FasL(h):c-FLIP-S(m.s.):FADD(h):proCaspase-8(h):c-FLIP-L-p43(h) (binding) | Fas(h) + FasL(h) + FADD(h) + Caspase-8-p43(h) + c-FLIP-L-p43(m.s.) <==> Fas(h):FasL(h):FADD(h):Caspase-8-p43(h):c-FLIP-L-p43(m.s.) (binding) | Apo2L(m.s.) + FADD(h) + c-FLIP-L(m.s.) + Caspase-8-p43(h) <==> Apo2L(m.s.):FADD(h):c-FLIP-L(m.s.):Caspase-8-p43(h) (binding) | proCaspase-8(h) + FADD(h) + RIP(h) + c-FLIP-L(h) <==> proCaspase-8(h):FADD(h):RIP(h):c-FLIP-L(h) (binding) | proCaspase-8(h) + FADD(h) + RIP(h) + c-FLIP-L(h) + c-FLIP-S(h) <==> proCaspase-8(h):FADD(h):RIP(h):c-FLIP-L(h):c-FLIP-S(h) (binding) | DR4(h) + DR5(h) + Caspase-8-p26(h) + FADD(h) + RIP(h) + c-FLIP-L-p43(h) + c-FLIP-S(h) <==> DR4(h):DR5(h):Caspase-8-p26(h):FADD(h):RIP(h):c-FLIP-L-p43(h):c-FLIP-S(h) (binding) | Fas(h) + Caspase-8-p43(h) + FADD(h) + RIP(h) + c-FLIP-L-p43(h) + c-FLIP-S(h) <==> Fas(h):Caspase-8-p43(h):FADD(h):RIP(h):c-FLIP-L-p43(h):c-FLIP-S(h) (binding) | TRAF2(h) + TRADD(h) + Caspase-8-p26(h) + FADD(h) + RIP(h) + c-FLIP-L-p43(h) <==> TRAF2(h):TRADD(h):Caspase-8-p26(h):FADD(h):RIP(h):c-FLIP-L-p43(h) (binding) | Fas(h) + FADD(h) + proCaspase-8(h) + c-FLIP-p22(m.s.) <==> Fas(h):FADD(h):proCaspase-8(h):c-FLIP-p22(m.s.) (binding) | Fas(h) + FADD(h) + c-FLIP-L-p43(h) + Caspase-8-p18(h) <==> Fas(h):FADD(h):c-FLIP-L-p43(h):Caspase-8-p18(h) (binding) | Fas(h) + FADD(h) + c-FLIP-R(h) + c-FLIP-L-p43(h) + Caspase-8-p18(h) <==> Fas(h):FADD(h):c-FLIP-R(h):c-FLIP-L-p43(h):Caspase-8-p18(h) (binding) | Fas(h) + FADD(h) + c-FLIP-S(h) + c-FLIP-L-p43(h) + Caspase-8-p43(h) <==> Fas(h):FADD(h):c-FLIP-S(h):c-FLIP-L-p43(h):Caspase-8-p43(h) (binding) | PIDD(m) + FADD(h) <==> PIDD(m):FADD(h) (binding) | PIDD(h) + FADD(h) <==> PIDD(h):FADD(h) (binding) | Fas(h) + FADD(h) + Caspase-8-p18(h) + Caspase-2-p33(h) <==> Fas(h):FADD(h):Caspase-8-p18(h):Caspase-2-p33(h) (binding) | Fas(h) + FADD(h) + proCaspase-2(h) + Caspase-8-p43(h) <==> Fas(h):FADD(h):proCaspase-2(h):Caspase-8-p43(h) (binding) | FADD(h) + proCaspase-2(h) <==> FADD(h):proCaspase-2(h) (binding) | Fas(h) + FADD(h) + proCaspase-8(h) <==> Fas(h):FADD(h):proCaspase-8(h) (binding) | APG5(h) + FADD(h) <==> APG5(h):FADD(h) (binding) | FADD(h) + ATP --> FADD(h){pS194} + ADP (phosphorylation) | proCaspase-8(h) + FADD(h) <==> proCaspase-8(h):FADD(h) (binding) | DAP3(h) + FADD(h) <==> DAP3(h):FADD(h) (binding) | Caspase-8(h) + FADD(h) <==> Caspase-8(h):FADD(h) (binding) | proCaspase-8(h) + FADD(h) + c-FLIP-L-p43(h) + c-FLIP-S(h) <==> proCaspase-8(h):FADD(h):c-FLIP-L-p43(h):c-FLIP-S(h) (binding) | FADD(h) + IRAK1(h) <==> FADD(h):IRAK1(h) (binding) | FADD(h) + RIP(m.s.) <==> FADD(h):RIP(m.s.) (binding) | Caspase-8-p43(h) + FasL(h) + FADD(h) + Fas(h) <==> Caspase-8-p43(h):FasL(h):FADD(h):Fas(h) (binding) | c-FLIP-R(h) + c-FLIP-L(h) + proCaspase-8a(h) + FADD(h) + Fas(h) <==> c-FLIP-R(h):c-FLIP-L(h):proCaspase-8a(h):FADD(h):Fas(h) (binding) | c-FLIP-R(h) + c-FLIP-L(h) + proCaspase-8b(h) + FADD(h) + Fas(h) <==> c-FLIP-R(h):c-FLIP-L(h):proCaspase-8b(h):FADD(h):Fas(h) (binding) | c-FLIP-R(h) + c-FLIP-L-p43(h) + Caspase-8a-p43(h) + FADD(h) + Fas(h) <==> c-FLIP-R(h):c-FLIP-L-p43(h):Caspase-8a-p43(h):FADD(h):Fas(h) (binding) | c-FLIP-R(h) + c-FLIP-L-p43(h) + Caspase-8b-p41(h) + FADD(h) + Fas(h) <==> c-FLIP-R(h):c-FLIP-L-p43(h):Caspase-8b-p41(h):FADD(h):Fas(h) (binding) | FADD(h) --> FADD(h) (expression). | PAR4(m.s.) --> FADD(h) (decrease of phosphorylation) | TNFR1(h) --> FADD(h) (binding) | proCaspase-8(h) --> FADD(h) (binding) | TRADD(h) --> FADD(h) (binding) | TRAF2(h) --> FADD(h) (binding) | Fas(h) + proCaspase-8(h) + FADD(h) <==> Fas(h):proCaspase-8(h):FADD(h) (binding) | Fas(h) + FADD(h) <==> Fas(h):FADD(h) (binding) | 2 FADD(h) <==> (FADD(h))2 (oligomerization) | FADD(h) --> FADD(h) (expression). |
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Post Transcriptional Modification From dbPTM | | Top | |
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Location (AA) |
PTM type |
Literature |
Database |
194 | Phosphoserine (Probable). | Swiss-Prot 53.0 | 194 | Phosphoserine (70-kDa kinas) | 11034606;10640736;15001534 | Phospho.ELM 6.0 |
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Methylation Profile From DiseaseMeth database | | Top | |
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Chromosome |
Location |
Source |
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chr11 |
Promoter: 69725417 - 69727417 | Agilent_014791 |
chr11 |
Promoter: 69725417 - 69727417 | GSE27584 |
chr11 |
Promoter: 69725417 - 69727417 | Agilent_014791_44K |