Bioinformatics and Systems Medicine Laboratory
General information | Expression | Regulation | Mutation | Interaction

Basic Information

Gene ID

9314

Name

KLF4

Synonymous

EZF|GKLF;Kruppel-like factor 4 (gut);KLF4;Kruppel-like factor 4 (gut)

Definition

Krueppel-like factor 4|endothelial Kruppel-like zinc finger protein|epithelial zinc finger protein EZF|gut-enriched krueppel-like factor

Position

9q31

Gene Type

protein-coding

Gene Regulation:

Transcription Factors
Post Transcriptional Modification From dbPTM
Methylation Profile From DiseaseMeth database

Transcription Factors

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Regulation From TransFac database

GKLF-isoform1(h) + p53(h) <==> p53(h):GKLF-isoform1(h) (binding)
GKLF-isoform1(h) --/ HBB(h) (DNA binding; transrepression).
GKLF-isoform1(h) --> CDKN1A(h) (DNA binding; transactivation).
GKLF-isoform1(h) --/ Hbb-b1(m) (DNA binding; transrepression).
KLF4(h) --> GKLF-isoform1(h) (expression).
KLF4(h) --> GKLF(h) (expression).
hsa-miR-7 --/ GKLF(h) (predicted)
HDAC1(h) + GKLFa(h) <==> HDAC1(h):GKLFa(h) (binding)
hdac2(h) + GKLFa(h) <==> hdac2(h):GKLFa(h) (binding)
GKLFa(h) --/ ITGAD(h) (DNA binding; transrepression).
KLF4(h) --> GKLFa(h) (expression).
HDAC1(h) + GKLF(h) <==> HDAC1(h):GKLF(h) (binding)
hdac2(h) + GKLF(h) <==> hdac2(h):GKLF(h) (binding)
GKLF(h) --> ITGAD(h) (DNA binding).
GKLF(h) --> SLC5A6(h) (DNA binding).
GKLF(h) + acetyl-CoA --> GKLF(h){aceK} + CoA (acetylation)
GKLF(h) --/ ENG(h) (transrepression)
GKLF(h) --/ ODC1(h) (transrepression)
GKLF(h) --> LAMA3(h) (transactivation)
GKLF(h) --> Odc1(m) (DNA binding; transactivation).
GKLF(h) --> GHRL(h) (DNA binding).
KLF4(h) --> GKLF(h) (expression).
KLF4(h) --> GKLF-isoform2(h) (expression).

Post Transcriptional Modification From dbPTM

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There is no record for KLF4

Methylation Profile From DiseaseMeth database

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Chromosome

Location

Source

chr9

Promoter: 109291076 - 109293076Agilent_014791

chr9

Promoter: 109291076 - 109293076GSE27584


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