Basic Information
Gene ID	9318
Name	COPS2
Synonymous	ALIEN\|CSN2\|SGN2\|TRIP15;COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis);COPS2;COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis)
Definition	COP9 signalosome complex subunit 2\|JAB1-containing signalosome subunit 2\|TR-interacting protein 15\|TRIP-15\|alien homolog\|signalosome subunit 2\|thyroid receptor interacting protein 15\|thyroid receptor-interacting protein 15
Position	15q21.2
Gene Type	protein-coding
Gene Regulation:	Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database

Transcription Factors

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Regulation From TransFac database
sin3a(h) + COPS2(h) <==> sin3a(h):COPS2(h) (binding)
T3R-beta1(r) + COPS2(h) <==> T3R-beta1(r):COPS2(h) (binding)
RXR-alpha(h) + COPS2(h) <==> RXR-alpha(h):COPS2(h) (binding)
wdr8(h) + COPS2(h) <==> wdr8(h):COPS2(h) (binding)
COPS2(h) --> HIF-1alpha(h) (increase of abundance)
COPS2(h) --> HIF2A(h) (increase of abundance)
COPS2(h) --> HIF-1alpha(h):VHL(m.s.) (decrease of binding)
COPS2(h) --> COPS2(h) (expression).
COPS2-isoform1(h) + CUL4A-isoform2(h) <==> COPS2-isoform1(h):CUL4A-isoform2(h) (binding)
COPS2-isoform1(h) + DDB1(h) <==> COPS2-isoform1(h):DDB1(h) (binding)
COPS2-isoform1(h) + DDB1(h):CUL4A-isoform2(h) <==> COPS2-isoform1(h):DDB1(h):CUL4A-isoform2(h) (binding)
COPS2(h) --> COPS2-isoform1(h) (expression).
T3R-alpha(r) + Alien(h) <==> T3R-alpha(r):Alien(h) (binding)
T3R-beta(h) + Alien(h) <==> T3R-beta(h):Alien(h) (binding)
Alien(h) + COUP-TF1(h) <==> Alien(h):COUP-TF1(h) (binding)
Alien(h) + sin3a(m) <==> Alien(h):sin3a(m) (binding)
Alien(h) + T3R(m.s.) <==> Alien(h):T3R(m.s.) (binding)
VDR(h) + Alien(h) <==> VDR(h):Alien(h) (binding)
T3R-alpha(c) + Alien(h) <==> T3R-alpha(c):Alien(h) (binding)
Alien(h) --/ Nppa(r) (transrepression)
COPS2(h) --> Alien(h) (expression).
VDR(h):Alien(h) <==> VDR(h) + Alien(h) (dissociation)
T3R-alpha(c):Alien(h) <==> T3R-alpha(c) + Alien(h) (dissociation)
COPS2(h) --> COPS2-isoform2(h) (expression).