Entrez Gene

General information | Expression | Regulation | Mutation | Interaction

Basic Information
Gene ID	11191
Name	PTENP1
Synonymous	PTEN-rs\|PTEN2\|PTH2\|psiPTEN;phosphatase and tensin homolog pseudogene 1;PTENP1;phosphatase and tensin homolog pseudogene 1
Definition	-
Position	9p21
Gene type	pseudo
Source	Count: 1; Pubmed_search
Sentence	Abstract
"PTENP1 is a highly homologous processed pseudogene of the tumor suppressor gene PTEN (MIM 601728) that itself exerts a tumor suppressive function by acting as a decoy for PTEN-targeting miRNAs . As a model for the protein-coding-independent role of RNAs, we describe the functional relationship between the mRNAs produced by the PTEN tumour suppressor gene and its pseudogene PTENP1 and the critical consequences of this interaction. We find that PTENP1 is biologically active as it can regulate cellular levels of PTEN and exert a growth-suppressive role."
"In this review, author summarized the gene as tumor suppressor in table 2."	"The discovery of numerous noncoding RNA (ncRNA) transcripts in species from yeast to mammals has dramatically altered our understanding of cell biology, especially the biology of diseases such as cancer. In humans, the identification of abundant long ncRNA (lncRNA) >200 bp has catalyzed their characterization as critical components of cancer biology. Recently, roles for lncRNAs as drivers of tumor suppressive and oncogenic functions have appeared in prevalent cancer types, such as breast and prostate cancer. In this review, we highlight the emerging impact of ncRNAs in cancer research, with a particular focus on the mechanisms and functions of lncRNAs."