Entrez Gene

General information | Expression | Regulation | Mutation | Interaction

Basic Information
Gene ID	84152
Name	PPP1R1B
Synonymous	DARPP-32\|DARPP32;protein phosphatase 1, regulatory (inhibitor) subunit 1B;PPP1R1B;protein phosphatase 1, regulatory (inhibitor) subunit 1B
Definition	dopamine and cAMP-regulated neuronal phosphoprotein 32\|protein phosphatase 1 regulatory subunit 1B
Position	17q12
Gene type	protein-coding
Source	Count: 1; Generif
Sentence	Abstract
The decreased expression of DARPP-32 in oral premalignant and malignant lesions suggests a tumor suppressor role for this protein in the tumorigenesis of these lesions.	BACKGROUND: DARPP-32 is a neuronal protein that plays a central role in dopaminergic neurotransmission. Although DARPP-32 may contribute to the pathogenesis of several human malignancies, its expression has never been investigated in oral premalignant and malignant lesions. MATERIALS AND METHODS: DARPP-32 expression was examined using immunohistochemistry in 14 normal oral mucosa, 5 normal lower lip mucosa, 41 oral leukoplakia (OL), 30 oral squamous cell carcinoma (OSCC) and 20 lower lip squamous cell carcinoma (LLSCC) specimens. Differences of its expression between groups were analyzed. RESULTS: OSCC and OL with moderate or severe dysplasia showed lower DARPP-32 expression in relation to normal oral mucosa. LLSCC showed lower DARPP-32 expression than normal lower lip mucosa and OSSC. CONCLUSION: The decreased expression of DARPP-32 in oral premalignant and malignant lesions suggests a tumor suppressor role for this protein in the tumorigenesis of these lesions.