Entrez Gene

General information | Expression | Regulation | Mutation | Interaction

Basic Information
Gene ID	9636
Name	ISG15
Synonymous	G1P2\|IFI15\|IP17\|UCRP\|hUCRP;ISG15 ubiquitin-like modifier;ISG15;ISG15 ubiquitin-like modifier
Definition	interferon, alpha-inducible protein (clone IFI-15K)\|interferon-induced 15 kDa protein\|interferon-induced 17 kDa protein\|interferon-induced 17-kDa/15-kDa protein\|interferon-stimulated protein, 15 kDa\|ubiquitin cross-reactive protein\|ubiquitin-like protein
Position	1p36.33
Gene type	protein-coding
Source	Count: 1; Generif
Sentence	Abstract
"review evidence of a role for ISG15 as an endogenous tumor suppressor that, when dysregulated in malignant cells, can be subverted to promote oncogenesis"	The interferon-stimulated gene, 15 kDa (ISG15) is an interferon regulated gene that is induced as a primary response to diverse microbial and cell stress stimuli, and encodes the founding member of the ubiquitin-like protein family. ISG15 post-translationally modifies proteins via a pathway parallel to, and partially overlapping with, that of ubiquitin. In addition, ISG15 is released from cells to mediate extracellular cytokine-like activities. Although the biological activities of ISG15 have yet to be fully elucidated, it is clear that ISG15 has the capacity to modulate diverse cellular and physiologic functions. Consistent with this view, alterations in the ISG15 pathway have been identified in human tumors and in tumor cell lines. Here we review evidence of a role for ISG15 as an endogenous tumor suppressor that, when dysregulated in malignant cells, can be subverted to promote oncogenesis.