| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS20047935 | HPV | ENSG00000163485.18 | protein_coding | ADORA1 | No | No | 134 | P30542 |
| TVIS20068926 | HPV | ENSG00000163485.18 | protein_coding | ADORA1 | No | No | 134 | P30542 |
| TVIS44043593 | HTLV-1 | ENSG00000163485.18 | protein_coding | ADORA1 | No | No | 134 | P30542 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | ADORA1 |
|---|---|
| DrugBank ID | DB01412 |
| Drug Name | Theobromine |
| Target ID | BE0000013 |
| UniProt ID | P30542 |
| Regulation Type | antagonist |
| PubMed IDs | 12602592; 16702031; 17372967; 17126319; 17162470; 17085856; 15095008; 3588607 |
| Citations | Chou CC, Vickroy TW: Antagonism of adenosine receptors by caffeine and caffeine metabolites in equine forebrain tissues. Am J Vet Res. 2003 Feb;64(2):216-24.@@Gaytan SP, Saadani-Makki F, Bodineau L, Frugiere A, Larnicol N, Pasaro R: Effect of postnatal exposure to caffeine on the pattern of adenosine A1 receptor distribution in respiration-related nuclei of the rat brainstem. Auton Neurosci. 2006 Jun 30;126-127:339-46. Epub 2006 May 15.@@Wang SJ: Caffeine facilitation of glutamate release from rat cerebral cortex nerve terminals (synaptosomes) through activation protein kinase C pathway: an interaction with presynaptic adenosine A1 receptors. Synapse. 2007 Jun;61(6):401-11.@@Rieg T, Schnermann J, Vallon V: Adenosine A1 receptors determine effects of caffeine on total fluid intake but not caffeine appetite. Eur J Pharmacol. 2007 Jan 26;555(2-3):174-7. Epub 2006 Oct 25.@@Mustafa S, Venkatesh P, Pasha K, Mullangi R, Srinivas NR: Altered intravenous pharmacokinetics of topotecan in rats with acute renal failure (ARF) induced by uranyl nitrate: do adenosine A1 antagonists (selective/non-selective) normalize the altered topotecan kinetics in ARF? Xenobiotica. 2006 Dec;36(12):1239-58.@@Listos J, Malec D, Fidecka S: Adenosine receptor antagonists intensify the benzodiazepine withdrawal signs in mice. Pharmacol Rep. 2006 Sep-Oct;58(5):643-51.@@Fisone G, Borgkvist A, Usiello A: Caffeine as a psychomotor stimulant: mechanism of action. Cell Mol Life Sci. 2004 Apr;61(7-8):857-72.@@Daly JW, Jacobson KA, Ukena D: Adenosine receptors: development of selective agonists and antagonists. Prog Clin Biol Res. 1987;230:41-63. |
| Groups | Investigational |
| Direct Classification | Xanthines |
| SMILES | CN1C=NC2=C1C(=O)NC(=O)N2C |
| Pathways | Caffeine Metabolism |
| PharmGKB | PA451646 |
| ChEMBL | CHEMBL1114 |
