| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS20047935 | HPV | ENSG00000163485.18 | protein_coding | ADORA1 | No | No | 134 | P30542 |
| TVIS20068926 | HPV | ENSG00000163485.18 | protein_coding | ADORA1 | No | No | 134 | P30542 |
| TVIS44043593 | HTLV-1 | ENSG00000163485.18 | protein_coding | ADORA1 | No | No | 134 | P30542 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | ADORA1 |
|---|---|
| DrugBank ID | DB00640 |
| Drug Name | Adenosine |
| Target ID | BE0000013 |
| UniProt ID | P30542 |
| Regulation Type | agonist |
| PubMed IDs | 20370662; 20370661; 17321471; 20136829; 17438146; 17442976 |
| Citations | Trincavelli ML, Daniele S, Martini C: Adenosine receptors: what we know and what we are learning. Curr Top Med Chem. 2010;10(9):860-77.@@Schenone S, Brullo C, Musumeci F, Bruno O, Botta M: A1 receptors ligands: past, present and future trends. Curr Top Med Chem. 2010;10(9):878-901.@@Ezeamuzie CI, Khan I: The role of adenosine A(2) receptors in the regulation of TNF-alpha production and PGE(2) release in mouse peritoneal macrophages. Int Immunopharmacol. 2007 Apr;7(4):483-90. Epub 2006 Dec 29.@@Buenestado A, Grassin Delyle S, Arnould I, Besnard F, Naline E, Blouquit-Laye S, Chapelier A, Bellamy JF, Devillier P: The role of adenosine receptors in regulating production of tumour necrosis factor-alpha and chemokines by human lung macrophages. Br J Pharmacol. 2010 Mar;159(6):1304-11. doi: 10.1111/j.1476-5381.2009.00614.x. Epub 2010 Feb 5.@@Funakoshi H, Zacharia LC, Tang Z, Zhang J, Lee LL, Good JC, Herrmann DE, Higuchi Y, Koch WJ, Jackson EK, Chan TO, Feldman AM: A1 adenosine receptor upregulation accompanies decreasing myocardial adenosine levels in mice with left ventricular dysfunction. Circulation. 2007 May 1;115(17):2307-15. Epub 2007 Apr 16.@@Haschemi A, Wagner O, Marculescu R, Wegiel B, Robson SC, Gagliani N, Gallo D, Chen JF, Bach FH, Otterbein LE: Cross-regulation of carbon monoxide and the adenosine A2a receptor in macrophages. J Immunol. 2007 May 1;178(9):5921-9. |
| Groups | Approved; Investigational |
| Direct Classification | Purine nucleosides |
| SMILES | NC1=C2N=CN([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)C2=NC=N1 |
| Pathways | Lesch-Nyhan Syndrome (LNS); Molybdenum Cofactor Deficiency; Xanthinuria Type I; Azathioprine Action Pathway; AICA-Ribosiduria; Homocystinuria-Megaloblastic Anemia Due to Defect in Cobalamin Metabolism, cblG Complementation Type; Purine Nucleoside Phosphorylase Deficiency; Methionine Adenosyltransferase Deficiency; Adenine Phosphoribosyltransferase Deficiency (APRT); Thioguanine Action Pathway; Mercaptopurine Action Pathway; Xanthine Dehydrogenase Deficiency (Xanthinuria); Betaine Metabolism; S-Adenosylhomocysteine (SAH) Hydrolase Deficiency; Intracellular Signalling Through Adenosine Receptor A2b and Adenosine; Intracellular Signalling Through Adenosine Receptor A2a and Adenosine; Glycine N-Methyltransferase Deficiency; Mitochondrial DNA Depletion Syndrome; Hypermethioninemia; Adenosine Deaminase Deficiency; Selenoamino Acid Metabolism; Xanthinuria Type II; Methionine Metabolism; Myoadenylate Deaminase Deficiency; Cystathionine beta-Synthase Deficiency; Methylenetetrahydrofolate Reductase Deficiency (MTHFRD); Purine Metabolism; Gout or Kelley-Seegmiller Syndrome; Adenylosuccinate Lyase Deficiency |
| PharmGKB | PA448049 |
| ChEMBL | CHEMBL477 |
