| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10010882 | HBV | ENSG00000105976.16 | protein_coding | MET | Yes | No | 4233 | E6Y365 P08581 |
| TVIS30067833 | HIV | ENSG00000105976.16 | protein_coding | MET | Yes | No | 4233 | E6Y365 P08581 |
| TVIS20012857 | HPV | ENSG00000105976.16 | protein_coding | MET | Yes | No | 4233 | E6Y365 P08581 |
| TVIS20062294 | HPV | ENSG00000105976.16 | protein_coding | MET | Yes | No | 4233 | E6Y365 P08581 |
| TVIS20023366 | HPV | ENSG00000105976.16 | protein_coding | MET | Yes | No | 4233 | E6Y365 P08581 |
| TVIS20022730 | HPV | ENSG00000105976.16 | protein_coding | MET | Yes | No | 4233 | E6Y365 P08581 |
| TVIS20061784 | HPV | ENSG00000105976.16 | protein_coding | MET | Yes | No | 4233 | E6Y365 P08581 |
| TVIS44016703 | HTLV-1 | ENSG00000105976.16 | protein_coding | MET | Yes | No | 4233 | E6Y365 P08581 |
| TVIS44049057 | HTLV-1 | ENSG00000105976.16 | protein_coding | MET | Yes | No | 4233 | E6Y365 P08581 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | MET |
|---|---|
| DrugBank ID | DB08875 |
| Drug Name | Cabozantinib |
| Target ID | BE0000915 |
| UniProt ID | P08581 |
| Regulation Type | antagonist |
| PubMed IDs | 21606412; 21926191 |
| Citations | Kurzrock R, Sherman SI, Ball DW, Forastiere AA, Cohen RB, Mehra R, Pfister DG, Cohen EE, Janisch L, Nauling F, Hong DS, Ng CS, Ye L, Gagel RF, Frye J, Muller T, Ratain MJ, Salgia R: Activity of XL184 (Cabozantinib), an oral tyrosine kinase inhibitor, in patients with medullary thyroid cancer. J Clin Oncol. 2011 Jul 1;29(19):2660-6. doi: 10.1200/JCO.2010.32.4145. Epub 2011 May 23.@@Yakes FM, Chen J, Tan J, Yamaguchi K, Shi Y, Yu P, Qian F, Chu F, Bentzien F, Cancilla B, Orf J, You A, Laird AD, Engst S, Lee L, Lesch J, Chou YC, Joly AH: Cabozantinib (XL184), a novel MET and VEGFR2 inhibitor, simultaneously suppresses metastasis, angiogenesis, and tumor growth. Mol Cancer Ther. 2011 Dec;10(12):2298-308. doi: 10.1158/1535-7163.MCT-11-0264. Epub 2011 Sep 16. |
| Groups | Approved; Investigational |
| Direct Classification | Diarylethers |
| SMILES | COC1=CC2=C(C=C1OC)C(OC1=CC=C(NC(=O)C3(CC3)C(=O)NC3=CC=C(F)C=C3)C=C1)=CC=N2 |
| Pathways | |
| PharmGKB | |
| ChEMBL | CHEMBL2105717 |
