| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10010882 | HBV | ENSG00000105976.16 | protein_coding | MET | Yes | No | 4233 | E6Y365 P08581 |
| TVIS30067833 | HIV | ENSG00000105976.16 | protein_coding | MET | Yes | No | 4233 | E6Y365 P08581 |
| TVIS20012857 | HPV | ENSG00000105976.16 | protein_coding | MET | Yes | No | 4233 | E6Y365 P08581 |
| TVIS20062294 | HPV | ENSG00000105976.16 | protein_coding | MET | Yes | No | 4233 | E6Y365 P08581 |
| TVIS20023366 | HPV | ENSG00000105976.16 | protein_coding | MET | Yes | No | 4233 | E6Y365 P08581 |
| TVIS20022730 | HPV | ENSG00000105976.16 | protein_coding | MET | Yes | No | 4233 | E6Y365 P08581 |
| TVIS20061784 | HPV | ENSG00000105976.16 | protein_coding | MET | Yes | No | 4233 | E6Y365 P08581 |
| TVIS44016703 | HTLV-1 | ENSG00000105976.16 | protein_coding | MET | Yes | No | 4233 | E6Y365 P08581 |
| TVIS44049057 | HTLV-1 | ENSG00000105976.16 | protein_coding | MET | Yes | No | 4233 | E6Y365 P08581 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | MET |
|---|---|
| DrugBank ID | DB08079 |
| Drug Name | AMG-208 |
| Target ID | BE0000915 |
| UniProt ID | P08581 |
| Regulation Type | inhibitor |
| PubMed IDs | 26155941 |
| Citations | Hong DS, Rosen P, Lockhart AC, Fu S, Janku F, Kurzrock R, Khan R, Amore B, Caudillo I, Deng H, Hwang YC, Loberg R, Ngarmchamnanrith G, Beaupre DM, Lee P: A first-in-human study of AMG 208, an oral MET inhibitor, in adult patients with advanced solid tumors. Oncotarget. 2015 Jul 30;6(21):18693-706. doi: 10.18632/oncotarget.4472. |
| Groups | Investigational |
| Direct Classification | Phenylpyridazines |
| SMILES | COC1=CC2=NC=CC(OCC3=NN=C4C=CC(=NN34)C3=CC=CC=C3)=C2C=C1 |
| Pathways | |
| PharmGKB | |
| ChEMBL | CHEMBL496102 |
