| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS20062394 | HPV | ENSG00000133742.14 | protein_coding | CA1 | No | No | 759 | P00915 |
| TVIS44045853 | HTLV-1 | ENSG00000133742.14 | protein_coding | CA1 | No | No | 759 | P00915 |
| TVIS44045852 | HTLV-1 | ENSG00000133742.14 | protein_coding | CA1 | No | No | 759 | P00915 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | CA1 |
|---|---|
| DrugBank ID | DB00880 |
| Drug Name | Chlorothiazide |
| Target ID | BE0000267 |
| UniProt ID | P00915 |
| Regulation Type | inhibitor |
| PubMed IDs | 10713865; 10954127 |
| Citations | Puscas I, Coltau M, Baican M, Domuta G, Hecht A: Vasodilatory effect of diuretics is dependent on inhibition of vascular smooth muscle carbonic anhydrase by a direct mechanism of action. Drugs Exp Clin Res. 1999;25(6):271-9.@@Puscas I, Coltau M, Baican M, Pasca R, Domuta G: The inhibitory effect of diuretics on carbonic anhydrases. Res Commun Mol Pathol Pharmacol. 1999;105(3):213-36. |
| Groups | Approved; Vet_approved |
| Direct Classification | 1,2,4-benzothiadiazine-1,1-dioxides |
| SMILES | NS(=O)(=O)C1=C(Cl)C=C2NC=NS(=O)(=O)C2=C1 |
| Pathways | Chlorothiazide Action Pathway |
| PharmGKB | PA448953 |
| ChEMBL | CHEMBL842 |
