| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS20062394 | HPV | ENSG00000133742.14 | protein_coding | CA1 | No | No | 759 | P00915 |
| TVIS44045853 | HTLV-1 | ENSG00000133742.14 | protein_coding | CA1 | No | No | 759 | P00915 |
| TVIS44045852 | HTLV-1 | ENSG00000133742.14 | protein_coding | CA1 | No | No | 759 | P00915 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | CA1 |
|---|---|
| DrugBank ID | DB00606 |
| Drug Name | Cyclothiazide |
| Target ID | BE0000267 |
| UniProt ID | P00915 |
| Regulation Type | inhibitor |
| PubMed IDs | 9929558; 8882618; 8793745; 9685234; 8003661 |
| Citations | Rammes G, Zeilhofer HU, Collingridge GL, Parsons CG, Swandulla D: Expression of early hippocampal CA1 LTP does not lead to changes in AMPA-EPSC kinetics or sensitivity to cyclothiazide. Pflugers Arch. 1999 Jan;437(2):191-6.@@Rammes G, Swandulla D, Collingridge GL, Hartmann S, Parsons CG: Interactions of 2,3-benzodiazepines and cyclothiazide at AMPA receptors: patch clamp recordings in cultured neurones and area CA1 in hippocampal slices. Br J Pharmacol. 1996 Mar;117(6):1209-21.@@Fleck MW, Bahring R, Patneau DK, Mayer ML: AMPA receptor heterogeneity in rat hippocampal neurons revealed by differential sensitivity to cyclothiazide. J Neurophysiol. 1996 Jun;75(6):2322-33.@@Pirotte B, Podona T, Diouf O, de Tullio P, Lebrun P, Dupont L, Somers F, Delarge J, Morain P, Lestage P, Lepagnol J, Spedding M: 4H-1,2,4-Pyridothiadiazine 1,1-dioxides and 2,3-dihydro-4H-1,2, 4-pyridothiadiazine 1,1-dioxides chemically related to diazoxide and cyclothiazide as powerful positive allosteric modulators of (R/S)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid receptors: design, synthesis, pharmacology, and structure-activity relationships. J Med Chem. 1998 Jul 30;41(16):2946-59.@@Larson J, Le TT, Hall RA, Lynch G: Effects of cyclothiazide on synaptic responses in slices of adult and neonatal rat hippocampus. Neuroreport. 1994 Jan 12;5(4):389-92. |
| Groups | Approved |
| Direct Classification | 1,2,4-benzothiadiazine-1,1-dioxides |
| SMILES | NS(=O)(=O)C1=C(Cl)C=C2NC(NS(=O)(=O)C2=C1)C1CC2CC1C=C2 |
| Pathways | Cyclothiazide Action Pathway |
| PharmGKB | PA449168 |
| ChEMBL | CHEMBL61593 |
