| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS20062394 | HPV | ENSG00000133742.14 | protein_coding | CA1 | No | No | 759 | P00915 |
| TVIS44045853 | HTLV-1 | ENSG00000133742.14 | protein_coding | CA1 | No | No | 759 | P00915 |
| TVIS44045852 | HTLV-1 | ENSG00000133742.14 | protein_coding | CA1 | No | No | 759 | P00915 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | CA1 |
|---|---|
| DrugBank ID | DB00273 |
| Drug Name | Topiramate |
| Target ID | BE0000267 |
| UniProt ID | P00915 |
| Regulation Type | inhibitor |
| PubMed IDs | 17826101; 10768298 |
| Citations | Nishimori I, Minakuchi T, Onishi S, Vullo D, Cecchi A, Scozzafava A, Supuran CT: Carbonic anhydrase inhibitors: cloning, characterization, and inhibition studies of the cytosolic isozyme III with sulfonamides. Bioorg Med Chem. 2007 Dec 1;15(23):7229-36. Epub 2007 Aug 25.@@Dodgson SJ, Shank RP, Maryanoff BE: Topiramate as an inhibitor of carbonic anhydrase isoenzymes. Epilepsia. 2000;41 Suppl 1:S35-9. doi: 10.1111/j.1528-1157.2000.tb06047.x. |
| Groups | Approved |
| Direct Classification | Dioxolopyrans |
| SMILES | [H][C@@]12CO[C@@]3(COS(N)(=O)=O)OC(C)(C)O[C@@]3([H])[C@]1([H])OC(C)(C)O2 |
| Pathways | |
| PharmGKB | PA451728 |
| ChEMBL | CHEMBL220492 |
