| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS20062394 | HPV | ENSG00000133742.14 | protein_coding | CA1 | No | No | 759 | P00915 |
| TVIS44045853 | HTLV-1 | ENSG00000133742.14 | protein_coding | CA1 | No | No | 759 | P00915 |
| TVIS44045852 | HTLV-1 | ENSG00000133742.14 | protein_coding | CA1 | No | No | 759 | P00915 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | CA1 |
|---|---|
| DrugBank ID | DB01144 |
| Drug Name | Diclofenamide |
| Target ID | BE0000267 |
| UniProt ID | P00915 |
| Regulation Type | inhibitor |
| PubMed IDs | 14684332; 9336012; 17228881; 19648295; 19019313 |
| Citations | Winum JY, Casini A, Mincione F, Starnotti M, Montero JL, Scozzafava A, Supuran CT: Carbonic anhydrase inhibitors: N-(p-sulfamoylphenyl)-alpha-D-glycopyranosylamines as topically acting antiglaucoma agents in hypertensive rabbits. Bioorg Med Chem Lett. 2004 Jan 5;14(1):225-9.@@Lindskog S: Structure and mechanism of carbonic anhydrase. Pharmacol Ther. 1997;74(1):1-20.@@Nishimori I, Minakuchi T, Onishi S, Vullo D, Scozzafava A, Supuran CT: Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors. J Med Chem. 2007 Jan 25;50(2):381-8.@@Giacomotto J, Pertl C, Borrel C, Walter MC, Bulst S, Johnsen B, Baillie DL, Lochmuller H, Thirion C, Segalat L: Evaluation of the therapeutic potential of carbonic anhydrase inhibitors in two animal models of dystrophin deficient muscular dystrophy. Hum Mol Genet. 2009 Nov 1;18(21):4089-101. doi: 10.1093/hmg/ddp358. Epub 2009 Jul 31.@@Cleland JC, Griggs RC: Treatment of neuromuscular channelopathies: current concepts and future prospects. Neurotherapeutics. 2008 Oct;5(4):607-12. doi: 10.1016/j.nurt.2008.09.001. |
| Groups | Approved; Investigational |
| Direct Classification | Benzenesulfonamides |
| SMILES | NS(=O)(=O)C1=CC(=C(Cl)C(Cl)=C1)S(N)(=O)=O |
| Pathways | |
| PharmGKB | PA164745512 |
| ChEMBL | CHEMBL17 |
