Target Gene Table
VIS IDVirusEnsembl IDGene TypeTarget GeneOncogeneTumor Suppressor GeneNCBI IDUniprot ID
TVIS30068105HIVENSG00000181072.12protein_codingCHRM2NoNo1129A4D1Q0
P08172
Q6SL56
Q6SL59
Q86SJ1
TVIS30068106HIVENSG00000181072.12protein_codingCHRM2NoNo1129A4D1Q0
P08172
Q6SL56
Q6SL59
Q86SJ1
TVIS20062080HPVENSG00000181072.12protein_codingCHRM2NoNo1129A4D1Q0
P08172
Q6SL56
Q6SL59
Q86SJ1
TVIS20061501HPVENSG00000181072.12protein_codingCHRM2NoNo1129A4D1Q0
P08172
Q6SL56
Q6SL59
Q86SJ1
TVIS20023329HPVENSG00000181072.12protein_codingCHRM2NoNo1129A4D1Q0
P08172
Q6SL56
Q6SL59
Q86SJ1
TVIS20038182HPVENSG00000181072.12protein_codingCHRM2NoNo1129A4D1Q0
P08172
Q6SL56
Q6SL59
Q86SJ1
TVIS20061739HPVENSG00000181072.12protein_codingCHRM2NoNo1129A4D1Q0
P08172
Q6SL56
Q6SL59
Q86SJ1
TVIS20043130HPVENSG00000181072.12protein_codingCHRM2NoNo1129A4D1Q0
P08172
Q6SL56
Q6SL59
Q86SJ1
TCGA Plot Options
Drug Information
GeneCHRM2
DrugBank IDDB00483
Drug NameGallamine triethiodide
Target IDBE0000560
UniProt IDP08172
Regulation Typeantagonist
PubMed IDs15937215; 11426849; 17588565; 9007524; 7522861; 18552124; 20083608; 18305010; 17944454; 11752352
CitationsHuang XP, Prilla S, Mohr K, Ellis J: Critical amino acid residues of the common allosteric site on the M2 muscarinic acetylcholine receptor: more similarities than differences between the structurally divergent agents gallamine and bis(ammonio)alkane-type hexamethylene-bis-[dimethyl-(3-phthalimidopropyl)ammonium]dibromide. Mol Pharmacol. 2005 Sep;68(3):769-78. Epub 2005 Jun 3.@@De Vries B, Roffel AF, Kooistra JM, Meurs H, Zaagsma J: Effects of fenoterol on beta-adrenoceptor and muscarinic M2 receptor function in bovine tracheal smooth muscle. Eur J Pharmacol. 2001 May 11;419(2-3):253-9.@@Cembala TM, Forde SC, Appadu BL, Lambert DG: Allosteric interaction of the neuromuscular blockers vecuronium and pancuronium with recombinant human muscarinic M2 receptors. Eur J Pharmacol. 2007 Aug 13;569(1-2):37-40. Epub 2007 May 22.@@Ten Berge RE, Krikke M, Teisman AC, Roffel AF, Zaagsma J: Dysfunctional muscarinic M2 autoreceptors in vagally induced bronchoconstriction of conscious guinea pigs after the early allergic reaction. Eur J Pharmacol. 1996 Dec 27;318(1):131-9.@@Spina D, Minshall E, Goldie RG, Page CP: The effect of allosteric antagonists in modulating muscarinic M2-receptor function in guinea-pig isolated trachea. Br J Pharmacol. 1994 Jul;112(3):901-5.@@Redka DS, Pisterzi LF, Wells JW: Binding of orthosteric ligands to the allosteric site of the M(2) muscarinic cholinergic receptor. Mol Pharmacol. 2008 Sep;74(3):834-43. doi: 10.1124/mol.108.048074. Epub 2008 Jun 13.@@Maier-Peuschel M, Frolich N, Dees C, Hommers LG, Hoffmann C, Nikolaev VO, Lohse MJ: A fluorescence resonance energy transfer-based M2 muscarinic receptor sensor reveals rapid kinetics of allosteric modulation. J Biol Chem. 2010 Mar 19;285(12):8793-800. doi: 10.1074/jbc.M109.098517. Epub 2010 Jan 18.@@Ehlert FJ, Griffin MT: Two-state models and the analysis of the allosteric effect of gallamine at the M2 muscarinic receptor. J Pharmacol Exp Ther. 2008 Jun;325(3):1039-60. doi: 10.1124/jpet.108.136960. Epub 2008 Feb 27.@@Elsinghorst PW, Cieslik JS, Mohr K, Trankle C, Gutschow M: First gallamine-tacrine hybrid: design and characterization at cholinesterases and the M2 muscarinic receptor. J Med Chem. 2007 Nov 15;50(23):5685-95. Epub 2007 Oct 18.@@Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5.
GroupsApproved
Direct ClassificationPhenol ethers
SMILES[I-].[I-].[I-].CC[N+](CC)(CC)CCOC1=CC=CC(OCC[N+](CC)(CC)CC)=C1OCC[N+](CC)(CC)CC
Pathways
PharmGKBPA164745088
ChEMBLCHEMBL1200993