| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10035966 | HBV | ENSG00000085563.15 | protein_coding | ABCB1 | Yes | No | 5243 | A4D1D2 P08183 |
| TVIS30067436 | HIV | ENSG00000085563.15 | protein_coding | ABCB1 | Yes | No | 5243 | A4D1D2 P08183 |
| TVIS20061554 | HPV | ENSG00000085563.15 | protein_coding | ABCB1 | Yes | No | 5243 | A4D1D2 P08183 |
| TVIS20061565 | HPV | ENSG00000085563.15 | protein_coding | ABCB1 | Yes | No | 5243 | A4D1D2 P08183 |
| TVIS20061861 | HPV | ENSG00000085563.15 | protein_coding | ABCB1 | Yes | No | 5243 | A4D1D2 P08183 |
| TVIS44008599 | HTLV-1 | ENSG00000085563.15 | protein_coding | ABCB1 | Yes | No | 5243 | A4D1D2 P08183 |
| TVIS44039492 | HTLV-1 | ENSG00000085563.15 | protein_coding | ABCB1 | Yes | No | 5243 | A4D1D2 P08183 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | ABCB1 |
|---|---|
| DrugBank ID | DB14066 |
| Drug Name | Tetrandrine |
| Target ID | BE0001032 |
| UniProt ID | P08183 |
| Regulation Type | inhibitor |
| PubMed IDs | 14666379; 28260091; 25233150 |
| Citations | Fu L, Liang Y, Deng L, Ding Y, Chen L, Ye Y, Yang X, Pan Q: Characterization of tetrandrine, a potent inhibitor of P-glycoprotein-mediated multidrug resistance. Cancer Chemother Pharmacol. 2004 Apr;53(4):349-56. doi: 10.1007/s00280-003-0742-5. Epub 2003 Dec 10.@@Lu Y, Li F, Xu T, Sun J: Tetrandrine prevents multidrug resistance in the osteosarcoma cell line, U-2OS, by preventing Pgp overexpression through the inhibition of NF-kappaB signaling. Int J Mol Med. 2017 Apr;39(4):993-1000. doi: 10.3892/ijmm.2017.2895. Epub 2017 Feb 17.@@Chen Y, Xiao X, Wang C, Jiang H, Hong Z, Xu G: Beneficial effect of tetrandrine on refractory epilepsy via suppressing P-glycoprotein. Int J Neurosci. 2015;125(9):703-10. doi: 10.3109/00207454.2014.966821. Epub 2014 Oct 22. |
| Groups | Experimental |
| Direct Classification | Lignans, neolignans and related compounds |
| SMILES | COC1=CC=C2C[C@@H]3N(C)CCC4=C3C(OC3=CC5=C(CCN(C)[C@H]5CC5=CC=C(OC1=C2)C=C5)C=C3OC)=C(OC)C(OC)=C4 |
| Pathways | |
| PharmGKB | |
| ChEMBL | CHEMBL176045 |
