| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10035966 | HBV | ENSG00000085563.15 | protein_coding | ABCB1 | Yes | No | 5243 | A4D1D2 P08183 |
| TVIS30067436 | HIV | ENSG00000085563.15 | protein_coding | ABCB1 | Yes | No | 5243 | A4D1D2 P08183 |
| TVIS20061554 | HPV | ENSG00000085563.15 | protein_coding | ABCB1 | Yes | No | 5243 | A4D1D2 P08183 |
| TVIS20061565 | HPV | ENSG00000085563.15 | protein_coding | ABCB1 | Yes | No | 5243 | A4D1D2 P08183 |
| TVIS20061861 | HPV | ENSG00000085563.15 | protein_coding | ABCB1 | Yes | No | 5243 | A4D1D2 P08183 |
| TVIS44008599 | HTLV-1 | ENSG00000085563.15 | protein_coding | ABCB1 | Yes | No | 5243 | A4D1D2 P08183 |
| TVIS44039492 | HTLV-1 | ENSG00000085563.15 | protein_coding | ABCB1 | Yes | No | 5243 | A4D1D2 P08183 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | ABCB1 |
|---|---|
| DrugBank ID | DB04877 |
| Drug Name | Voacamine |
| Target ID | BE0001032 |
| UniProt ID | P08183 |
| Regulation Type | inhibitor |
| PubMed IDs | 16273216; 14612920 |
| Citations | Meschini S, Marra M, Condello M, Calcabrini A, Federici E, Dupuis ML, Cianfriglia M, Arancia G: Voacamine, an alkaloid extracted from Peschiera fuchsiaefolia, inhibits P-glycoprotein action in multidrug-resistant tumor cells. Int J Oncol. 2005 Dec;27(6):1597-603.@@Meschini S, Marra M, Calcabrini A, Federici E, Galeffi C, Arancia G: Voacamine, a bisindolic alkaloid from Peschiera fuchsiaefolia, enhances the cytotoxic effect of doxorubicin on multidrug-resistant tumor cells. Int J Oncol. 2003 Dec;23(6):1505-13. |
| Groups | Experimental |
| Direct Classification | Ibogan-type alkaloids |
| SMILES | [H][C@@]12C[C@H](CC)[C@]3([H])N(C1)CCC1=C(NC4=CC(=C(OC)C=C14)[C@@]1([H])C[C@]4([H])C(C(=O)OC)[C@@]([H])(CC5=C1NC1=CC=CC=C51)N(C)CC4=CC)[C@@]3(C2)C(=O)OC |
| Pathways | |
| PharmGKB | PA165958347 |
| ChEMBL | CHEMBL445022 |
