Target Gene Table ▼
VIS IDVirusEnsembl IDGene TypeTarget GeneOncogeneTumor Suppressor GeneNCBI IDUniprot ID
TVIS10004169HBVENSG00000133019.12protein_codingCHRM3NoNo1131P20309
TVIS10006529HBVENSG00000133019.12protein_codingCHRM3NoNo1131P20309
TVIS10013404HBVENSG00000133019.12protein_codingCHRM3NoNo1131P20309
TVIS10013405HBVENSG00000133019.12protein_codingCHRM3NoNo1131P20309
TVIS10013406HBVENSG00000133019.12protein_codingCHRM3NoNo1131P20309
TVIS10013407HBVENSG00000133019.12protein_codingCHRM3NoNo1131P20309
TVIS10013408HBVENSG00000133019.12protein_codingCHRM3NoNo1131P20309
TVIS10013409HBVENSG00000133019.12protein_codingCHRM3NoNo1131P20309
TVIS10013410HBVENSG00000133019.12protein_codingCHRM3NoNo1131P20309
TVIS10013411HBVENSG00000133019.12protein_codingCHRM3NoNo1131P20309
TCGA Plot Options ▼
Drug Information ▼
GeneCHRM3
DrugBank IDDB01142
Drug NameDoxepin
Target IDBE0000045
UniProt IDP20309
Regulation Typeantagonist
PubMed IDs7855217; 2329499; 2141000
CitationsCusack B, Nelson A, Richelson E: Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl). 1994 May;114(4):559-65.@@Ehlert FJ, Delen FM, Yun SH, Liem HA: The interaction of amitriptyline, doxepin, imipramine and their N-methyl quaternary ammonium derivatives with subtypes of muscarinic receptors in brain and heart. J Pharmacol Exp Ther. 1990 Apr;253(1):13-9.@@Figueiredo A, Ribeiro CA, Goncalo M, Almeida L, Poiares-Baptista A, Teixeira F: Mechanism of action of doxepin in the treatment of chronic urticaria. Fundam Clin Pharmacol. 1990;4(2):147-58.
GroupsApproved; Investigational
Direct ClassificationDibenzoxepines
SMILES[H]C(CCN(C)C)=C1C2=CC=CC=C2COC2=CC=CC=C12
PathwaysDoxepin Metabolism Pathway; Doxepin H1-Antihistamine Action
PharmGKBPA449409
ChEMBLCHEMBL1628227