| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10013213 | HBV | ENSG00000126218.12 | protein_coding | F10 | No | No | 2159 | P00742 Q5JVE7 Q5JVE8 |
| TVIS10020895 | HBV | ENSG00000126218.12 | protein_coding | F10 | No | No | 2159 | P00742 Q5JVE7 Q5JVE8 |
| TVIS30020164 | HIV | ENSG00000126218.12 | protein_coding | F10 | No | No | 2159 | P00742 Q5JVE7 Q5JVE8 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | F10 |
|---|---|
| DrugBank ID | DB12364 |
| Drug Name | Betrixaban |
| Target ID | BE0000216 |
| UniProt ID | P00742 |
| Regulation Type | inhibitor |
| PubMed IDs | 23487517; 19297154; 26170684; 25673997 |
| Citations | Connolly SJ, Eikelboom J, Dorian P, Hohnloser SH, Gretler DD, Sinha U, Ezekowitz MD: Betrixaban compared with warfarin in patients with atrial fibrillation: results of a phase 2, randomized, dose-ranging study (Explore-Xa). Eur Heart J. 2013 May;34(20):1498-505. doi: 10.1093/eurheartj/eht039. Epub 2013 Mar 13.@@Zhang P, Huang W, Wang L, Bao L, Jia ZJ, Bauer SM, Goldman EA, Probst GD, Song Y, Su T, Fan J, Wu Y, Li W, Woolfrey J, Sinha U, Wong PW, Edwards ST, Arfsten AE, Clizbe LA, Kanter J, Pandey A, Park G, Hutchaleelaha A, Lambing JL, Hollenbach SJ, Scarborough RM, Zhu BY: Discovery of betrixaban (PRT054021), N-(5-chloropyridin-2-yl)-2-(4-(N,N-dimethylcarbamimidoyl)benzamido)-5-methoxybenz amide, a highly potent, selective, and orally efficacious factor Xa inhibitor. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2179-85. doi: 10.1016/j.bmcl.2009.02.111. Epub 2009 Mar 3.@@Chan NC, Bhagirath V, Eikelboom JW: Profile of betrixaban and its potential in the prevention and treatment of venous thromboembolism. Vasc Health Risk Manag. 2015 Jun 26;11:343-51. doi: 10.2147/VHRM.S63060. eCollection 2015.@@Cabral KP, Ansell JE: The role of factor Xa inhibitors in venous thromboembolism treatment. Vasc Health Risk Manag. 2015 Jan 30;11:117-23. doi: 10.2147/VHRM.S39726. eCollection 2015. |
| Groups | Approved; Investigational |
| Direct Classification | Benzanilides |
| SMILES | COC1=CC=C(NC(=O)C2=CC=C(C=C2)C(=N)N(C)C)C(=C1)C(=O)NC1=CC=C(Cl)C=N1 |
| Pathways | |
| PharmGKB | |
| ChEMBL | CHEMBL512351 |
