| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10013213 | HBV | ENSG00000126218.12 | protein_coding | F10 | No | No | 2159 | P00742 Q5JVE7 Q5JVE8 |
| TVIS10020895 | HBV | ENSG00000126218.12 | protein_coding | F10 | No | No | 2159 | P00742 Q5JVE7 Q5JVE8 |
| TVIS30020164 | HIV | ENSG00000126218.12 | protein_coding | F10 | No | No | 2159 | P00742 Q5JVE7 Q5JVE8 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | F10 |
|---|---|
| DrugBank ID | DB13923 |
| Drug Name | Emicizumab |
| Target ID | BE0000216 |
| UniProt ID | P00742 |
| Regulation Type | activator |
| PubMed IDs | 26626991; 27223146; 6424437; 27207420 |
| Citations | Uchida N, Sambe T, Yoneyama K, Fukazawa N, Kawanishi T, Kobayashi S, Shima M: A first-in-human phase 1 study of ACE910, a novel factor VIII-mimetic bispecific antibody, in healthy subjects. Blood. 2016 Mar 31;127(13):1633-41. doi: 10.1182/blood-2015-06-650226. Epub 2015 Dec 1.@@Shima M, Hanabusa H, Taki M, Matsushita T, Sato T, Fukutake K, Fukazawa N, Yoneyama K, Yoshida H, Nogami K: Factor VIII-Mimetic Function of Humanized Bispecific Antibody in Hemophilia A. N Engl J Med. 2016 May 26;374(21):2044-53. doi: 10.1056/NEJMoa1511769.@@Chavin SI: Factor VIII: structure and function in blood clotting. Am J Hematol. 1984 Apr;16(3):297-306.@@Nogami K: Bispecific antibody mimicking factor VIII. Thromb Res. 2016 May;141 Suppl 2:S34-5. doi: 10.1016/S0049-3848(16)30361-9. |
| Groups | Approved; Investigational |
| Direct Classification | Peptides |
| SMILES | |
| Pathways | |
| PharmGKB | |
| ChEMBL |
