Target Gene Table
VIS IDVirusEnsembl IDGene TypeTarget GeneOncogeneTumor Suppressor GeneNCBI IDUniprot ID
TVIS10004907HBVENSG00000070915.10protein_codingSLC12A3NoNo6559J3QSS1
P55017
TVIS10002672HBVENSG00000070915.10protein_codingSLC12A3NoNo6559J3QSS1
P55017
TVIS10022547HBVENSG00000070915.10protein_codingSLC12A3NoNo6559J3QSS1
P55017
TVIS10027635HBVENSG00000070915.10protein_codingSLC12A3NoNo6559J3QSS1
P55017
TVIS10049843HBVENSG00000070915.10protein_codingSLC12A3NoNo6559J3QSS1
P55017
TVIS30041140HIVENSG00000070915.10protein_codingSLC12A3NoNo6559J3QSS1
P55017
TVIS20052662HPVENSG00000070915.10protein_codingSLC12A3NoNo6559J3QSS1
P55017
TVIS44023796HTLV-1ENSG00000070915.10protein_codingSLC12A3NoNo6559J3QSS1
P55017
TVIS44023797HTLV-1ENSG00000070915.10protein_codingSLC12A3NoNo6559J3QSS1
P55017
TVIS44047476HTLV-1ENSG00000070915.10protein_codingSLC12A3NoNo6559J3QSS1
P55017
TCGA Plot Options
Drug Information
GeneSLC12A3
DrugBank IDDB01324
Drug NamePolythiazide
Target IDBE0000419
UniProt IDP55017
Regulation Typeinhibitor
PubMed IDs11752352; 10894798; 12217863; 19474192
CitationsChen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5.@@Monroy A, Plata C, Hebert SC, Gamba G: Characterization of the thiazide-sensitive Na(+)-Cl(-) cotransporter: a new model for ions and diuretics interaction. Am J Physiol Renal Physiol. 2000 Jul;279(1):F161-9.@@Frindt G, McNair T, Dahlmann A, Jacobs-Palmer E, Palmer LG: Epithelial Na channels and short-term renal response to salt deprivation. Am J Physiol Renal Physiol. 2002 Oct;283(4):F717-26.@@Gamba G: The thiazide-sensitive Na+-Cl- cotransporter: molecular biology, functional properties, and regulation by WNKs. Am J Physiol Renal Physiol. 2009 Oct;297(4):F838-48. doi: 10.1152/ajprenal.00159.2009. Epub 2009 May 27.
GroupsApproved
Direct Classification1,2,4-benzothiadiazine-1,1-dioxides
SMILESCN1C(CSCC(F)(F)F)NC2=CC(Cl)=C(C=C2S1(=O)=O)S(N)(=O)=O
PathwaysPolythiazide Action Pathway
PharmGKBPA164748763
ChEMBLCHEMBL1587