| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10010853 | HBV | ENSG00000170214.5 | protein_coding | ADRA1B | No | No | 147 | P35368 |
| TVIS10010854 | HBV | ENSG00000170214.5 | protein_coding | ADRA1B | No | No | 147 | P35368 |
| TVIS20024833 | HPV | ENSG00000170214.5 | protein_coding | ADRA1B | No | No | 147 | P35368 |
| TVIS20065388 | HPV | ENSG00000170214.5 | protein_coding | ADRA1B | No | No | 147 | P35368 |
| TVIS20023848 | HPV | ENSG00000170214.5 | protein_coding | ADRA1B | No | No | 147 | P35368 |
| TVIS44016411 | HTLV-1 | ENSG00000170214.5 | protein_coding | ADRA1B | No | No | 147 | P35368 |
| TVIS44025476 | HTLV-1 | ENSG00000170214.5 | protein_coding | ADRA1B | No | No | 147 | P35368 |
| TVIS44000687 | HTLV-1 | ENSG00000170214.5 | protein_coding | ADRA1B | No | No | 147 | P35368 |
| TVIS44029351 | HTLV-1 | ENSG00000170214.5 | protein_coding | ADRA1B | No | No | 147 | P35368 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | ADRA1B |
|---|---|
| DrugBank ID | DB00368 |
| Drug Name | Norepinephrine |
| Target ID | BE0000575 |
| UniProt ID | P35368 |
| Regulation Type | agonist |
| PubMed IDs | 17139284; 17016423; 8294418; 7773533; 8166240; 17266602; 18064417 |
| Citations | Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.@@Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34.@@Izzo NJ Jr, Tulenko TN, Colucci WS: Phorbol esters and norepinephrine destabilize alpha 1B-adrenergic receptor mRNA in vascular smooth muscle cells. J Biol Chem. 1994 Jan 21;269(3):1705-10.@@Testa R, Guarneri L, Poggesi E, Simonazzi I, Taddei C, Leonardi A: Mediation of noradrenaline-induced contractions of rat aorta by the alpha 1B-adrenoceptor subtype. Br J Pharmacol. 1995 Feb;114(4):745-50.@@Izzo NJ Jr, Colucci WS: Regulation of alpha 1B-adrenergic receptor half-life: protein synthesis dependence and effect of norepinephrine. Am J Physiol. 1994 Mar;266(3 Pt 1):C771-5.@@Bishop MJ: Recent advances in the discovery of alpha1-adrenoceptor agonists. Curr Top Med Chem. 2007;7(2):135-45.@@Gilsbach R, Hein L: Presynaptic metabotropic receptors for acetylcholine and adrenaline/noradrenaline. Handb Exp Pharmacol. 2008;(184):261-88. |
| Groups | Approved |
| Direct Classification | Catechols |
| SMILES | NC[C@H](O)C1=CC(O)=C(O)C=C1 |
| Pathways | Remifentanil Action Pathway; Hydrocodone Action Pathway; Sufentanil Action Pathway; Fluoxetine Action Pathway; Morphine Action Pathway; 3-Methylthiofentanyl Action Pathway; Benzocaine Action Pathway; Oxybuprocaine Action Pathway; Codeine Action Pathway; Alkaptonuria; Tyrosine Hydroxylase Deficiency; Ketobemidone Action Pathway; Propoxyphene Action Pathway; Dihydromorphine Action Pathway; Nicotine Action Pathway; Proparacaine Action Pathway; Methadyl Acetate Action Pathway; Hawkinsinuria; Oxymorphone Action Pathway; Dimethylthiambutene Action Pathway; Fentanyl Action Pathway; Dopamine beta-Hydroxylase Deficiency; Lidocaine (Local Anaesthetic) Action Pathway; Monoamine Oxidase-A Deficiency (MAO-A); Aromatic L-Aminoacid Decarboxylase Deficiency; Hydromorphone Action Pathway; Tyrosinemia, Transient, of the Newborn; Anileridine Action Pathway; Bupivacaine Action Pathway; Levallorphan Action Pathway |
| PharmGKB | PA450649 |
| ChEMBL | CHEMBL1437 |
