Gene: HDAC5

10014
HD5|NY-CO-9
histone deacetylase 5
protein-coding
17q21.31
Ensembl:ENSG00000108840 MIM:605315 Vega:OTTHUMG00000181806 UniprotKB:Q9UQL6
NC_000017.11
PubMed|SNP Mapped
1   ANCO-SNPs
CD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.754e-1 (AD)  8.049e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs79605584chr17:44122308 (GRCh38.p7)G>Acocaine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
BRSK10.927
SBF10.925
MAP3K100.925
PPP1R9B0.923
EVI5L0.922
B3GAT10.918
ZC3H7B0.917
CACNG70.917
JPH30.916
DACT30.916

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.701
OR4F29-0.668
IL18RAP-0.468
TFPI2-0.439
KCNJ15-0.417
TRIM10-0.412
C1orf87-0.412
CST7-0.404
TREM1-0.401
CXCR1-0.401

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB05015BelinostatSmall Molecule866323-14-0Approved|InvestigationalTarget
DB06603PanobinostatSmall Molecule404950-80-7Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0163923,3'-diindolylmethane"3,3'-diindolylmethane promotes the reaction [enterotoxin B, staphylococcal results in decreased expression of HDAC5 mRNA]"24200994
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of HDAC5 mRNA"28973690
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HDAC5 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HDAC5 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HDAC5 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HDAC5 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of HDAC5 mRNA17562736
D020106AcrylamideAcrylamide results in decreased expression of HDAC5 mRNA28959563
C031143AICA ribonucleotideAICA ribonucleotide inhibits the reaction [[HDAC5 protein binds to MEF2 protein] which binds to CTNNB1 promoter]21454484
C031143AICA ribonucleotideAICA ribonucleotide results in increased phosphorylation of HDAC5 protein21454484
C031143AICA ribonucleotide[AICA ribonucleotide results in increased phosphorylation of HDAC5 protein] which results in increased expression of CTNNB1 mRNA21454484
C031143AICA ribonucleotide[AICA ribonucleotide results in increased phosphorylation of HDAC5 protein] which results in increased expression of CTNNB1 protein21454484
D0157614-Aminopyridine[Bicuculline co-treated with 4-Aminopyridine] affects the localization of HDAC5 protein15773917
D000643Ammonium ChlorideAmmonium Chloride affects the expression of HDAC5 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of HDAC5 mRNA24449571
D001151ArsenicArsenic affects the methylation of HDAC5 gene25304211
D001280AtrazineAtrazine results in increased expression of HDAC5 mRNA26518232
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of HDAC5 mRNA26001963
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of HDAC5 mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of HDAC5 mRNA22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of HDAC5 protein26358852
D001599BerberineBerberine results in increased expression of HDAC5 mRNA27311644
D004958EstradiolEGF protein inhibits the reaction [Estradiol results in decreased expression of HDAC5 mRNA]24758408
D004958EstradiolEstradiol results in decreased expression of HDAC5 mRNA24758408
D004958EstradiolEstradiol affects the expression of HDAC5 mRNA15598610
D001640Bicuculline[Bicuculline co-treated with 4-Aminopyridine] affects the localization of HDAC5 protein15773917
C006780bisphenol Abisphenol A results in increased expression of HDAC5 mRNA29027980
C006780bisphenol Abisphenol A affects the methylation of HDAC5 promoter27334623
C006780bisphenol Abisphenol A results in increased expression of HDAC5 mRNA25181051
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of HDAC5 mRNA22079614
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of HDAC5 mRNA17484886
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of HDAC5 mRNA27339419
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of HDAC5 mRNA27396813
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of HDAC5 mRNA28472532
D002994ClofibrateClofibrate results in decreased expression of HDAC5 mRNA17585979
D003042CocaineCocaine results in decreased activity of HDAC5 protein17988634
D003042CocaineCocaine results in increased phosphorylation of and results in increased localization of HDAC5 protein17988634
D003042CocaineHDAC5 affects the reaction [Cocaine affects the expression of ABCA5 mRNA]17988634
D003042CocaineHDAC5 affects the reaction [Cocaine affects the expression of ADAM1A mRNA]17988634
D003042CocaineHDAC5 affects the reaction [Cocaine affects the expression of CUEDC1 mRNA]17988634
D003042CocaineHDAC5 affects the reaction [Cocaine affects the expression of ERBIN mRNA]17988634
D003042CocaineHDAC5 affects the reaction [Cocaine affects the expression of GNB4 mRNA]17988634
D003042CocaineHDAC5 affects the reaction [Cocaine affects the expression of GRIN2A mRNA]17988634
D003042CocaineHDAC5 affects the reaction [Cocaine affects the expression of KCNK4 mRNA]17988634
D003042CocaineHDAC5 affects the reaction [Cocaine affects the expression of KCNQ5 mRNA]17988634
D003042CocaineHDAC5 affects the reaction [Cocaine affects the expression of PRM1 mRNA]17988634
D003042CocaineHDAC5 affects the reaction [Cocaine affects the expression of RAPGEF6 mRNA]17988634
D003042CocaineHDAC5 affects the reaction [Cocaine affects the expression of RGS20 mRNA]17988634
D003042CocaineHDAC5 affects the reaction [Cocaine affects the expression of SUV39H1 mRNA]17988634
D003042CocaineHDAC5 affects the reaction [Cocaine affects the expression of TACR1 mRNA]17988634
D003042CocaineHDAC5 affects the reaction [Cocaine affects the expression of WNT5A mRNA]17988634
D003042CocaineHDAC5 results in decreased susceptibility to Cocaine17988634
C014347decitabinedecitabine results in increased expression of HDAC5 mRNA27915011
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of HDAC5 mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of HDAC5 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of HDAC5 mRNA27392435
D002945CisplatinCisplatin results in increased expression of HDAC5 mRNA27594783
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of HDAC5 mRNA26924002
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of HDAC5 mRNA25068794
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of HDAC5 mRNA"22485181
C024629dimethyl phthalatedimethyl phthalate affects the expression of HDAC5 mRNA26924002
D004317DoxorubicinDoxorubicin results in decreased expression of HDAC5 mRNA28865727
C031818enterotoxin B, staphylococcal"3,3'-diindolylmethane promotes the reaction [enterotoxin B, staphylococcal results in decreased expression of HDAC5 mRNA]"24200994
C031818enterotoxin B, staphylococcal"enterotoxin B, staphylococcal results in decreased expression of HDAC5 mRNA"24200994
C045651epigallocatechin gallateepigallocatechin gallate results in decreased expression of HDAC5 mRNA18851785
D000431EthanolEthanol promotes the reaction [HDAC3 protein binds to HDAC4 protein binds to HDAC5 protein binds to HDAC7 protein]23544086
D000431EthanolEthanol results in increased expression of HDAC5 protein23544086
D000431Ethanoltauroursodeoxycholic acid inhibits the reaction [Ethanol promotes the reaction [HDAC3 protein binds to HDAC4 protein binds to HDAC5 protein binds to HDAC7 protein]]23544086
D000431Ethanoltauroursodeoxycholic acid inhibits the reaction [Ethanol results in increased expression of HDAC5 protein]23544086
D005473FluoxetineHDAC5 protein results in increased susceptibility to Fluoxetine22113448
D004397FonofosFonofos results in increased methylation of HDAC5 promoter22847954
C069837fullerene C60fullerene C60 results in decreased expression of HDAC5 mRNA19167457
C081021Go 6976Go 6976 inhibits the reaction [[Tetradecanoylphorbol Acetate results in increased activity of PRKD1 protein] which affects the localization of HDAC5 protein]19124542
D006997Hypochlorous AcidHypochlorous Acid results in decreased expression of HDAC5 mRNA19376150
D007099ImipramineImipramine results in increased expression of HDAC5 mRNA17988634
D007213IndomethacinIndomethacin results in increased expression of HDAC5 mRNA28201806
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of HDAC5 mRNA27392435
C072105KN 93KN 93 inhibits the reaction [Potassium Chloride results in increased phosphorylation of HDAC5 protein]17988634
C406082monomethylarsonous acidmonomethylarsonous acid results in increased expression of HDAC5 mRNA23891734
C406082monomethylarsonous acid[vorinostat co-treated with monomethylarsonous acid] results in decreased expression of HDAC5 mRNA23891734
C406082monomethylarsonous acidmonomethylarsonous acid results in decreased expression of HDAC5 mRNA20024957
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of HDAC5 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of HDAC5 mRNA"25554681
C017096n-butoxyethanoln-butoxyethanol results in decreased expression of HDAC5 mRNA19812364
D009532NickelNickel results in decreased expression of HDAC5 mRNA24768652|2558310
C028007nickel monoxidenickel monoxide affects the expression of HDAC5 mRNA19167457
D010100OxygenOxygen deficiency results in increased expression of HDAC5 protein22711276
D010278ParathionParathion results in increased methylation of HDAC5 promoter22847954
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of HDAC5 mRNA18593933
D010656Phenylephrine[Phenylephrine results in increased activity of PRKD1 protein] which affects the localization of HDAC5 protein19124542
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HDAC5 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of HDAC5 mRNA26272509
D010705PhosgenePhosgene affects the expression of HDAC5 mRNA16300373
D010936Plant ExtractsPlant Extracts results in decreased expression of HDAC5 mRNA23557933
D011189Potassium ChlorideKN 93 inhibits the reaction [Potassium Chloride results in increased phosphorylation of HDAC5 protein]17988634
D011189Potassium ChloridePotassium Chloride results in increased phosphorylation of HDAC5 protein17988634
C045950propiconazolepropiconazole results in decreased expression of HDAC5 mRNA21278054
C107773pterostilbeneHDAC5 protein affects the reaction [pterostilbene results in increased expression of SOD2 mRNA]26443543
C107773pterostilbenePRKAA1 protein affects the reaction [pterostilbene results in increased phosphorylation of HDAC5 protein]26443543
C107773pterostilbenepterostilbene inhibits the reaction [HDAC5 protein binds to SOD2 promoter]26443543
C107773pterostilbenepterostilbene results in increased phosphorylation of HDAC5 protein26443543
C059514resveratrolresveratrol inhibits the reaction [HDAC5 protein binds to SOD2 promoter]26443543
C059514resveratrolresveratrol results in increased phosphorylation of HDAC5 protein26443543
D012293Rifampin[Rifampin co-treated with NR1I2 protein] results in decreased expression of HDAC5 mRNA21127053
C410733scriptaidscriptaid results in decreased activity of HDAC5 protein21454484
C410733scriptaid[scriptaid results in decreased activity of HDAC5 protein] which results in increased expression of CTNNB1 mRNA21454484
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of HDAC5 mRNA25895662
C031655tauroursodeoxycholic acidtauroursodeoxycholic acid inhibits the reaction [Ethanol promotes the reaction [HDAC3 protein binds to HDAC4 protein binds to HDAC5 protein binds to HDAC7 protein]]23544086
C031655tauroursodeoxycholic acidtauroursodeoxycholic acid inhibits the reaction [Ethanol results in increased expression of HDAC5 protein]23544086
C012568terbufosterbufos results in increased methylation of HDAC5 promoter22847954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of HDAC5 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of HDAC5 mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of HDAC5 mRNA19465110
D013755Tetradecanoylphorbol AcetateGo 6976 inhibits the reaction [[Tetradecanoylphorbol Acetate results in increased activity of PRKD1 protein] which affects the localization of HDAC5 protein]19124542
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate results in increased activity of PRKD1 protein] which affects the localization of HDAC5 protein19124542
D019284ThapsigarginThapsigargin results in increased expression of HDAC5 mRNA22378314
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of HDAC5 mRNA28065790
D014212TretinoinTretinoin results in increased expression of HDAC5 mRNA23724009
C012589trichostatin Atrichostatin A results in decreased activity of HDAC5 protein17988634|2569960
C057693troglitazonetroglitazone results in decreased expression of HDAC5 mRNA28973697
D014520UrethaneUrethane results in increased expression of HDAC5 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HDAC5 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of HDAC5 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of HDAC5 mRNA23179753|2627250
D014635Valproic AcidValproic Acid affects the expression of HDAC5 mRNA17292431
D014810Vitamin EVitamin E results in increased expression of HDAC5 mRNA19244175
C111237vorinostat[vorinostat co-treated with monomethylarsonous acid] results in decreased expression of HDAC5 mRNA23891734
C111237vorinostatvorinostat results in decreased activity of HDAC5 protein17988634
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of HDAC5 mRNA18593933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IDA24413532  
GO:0001085RNA polymerase II transcription factor binding-IPI23867755  
GO:0003682chromatin binding-IEA-  
GO:0004407histone deacetylase activity-IDA10869435  
GO:0005080protein kinase C binding-IPI20188095  
GO:0005515protein binding-IPI10737771  10869435  10898795  15161933  15194749  15923258  
16919237  17075044  17872950  18711143  19666599  22649097  
23752268  24229708  24413532  
GO:0008134transcription factor binding-IPI19071119  20408817  
GO:0032041NAD-dependent histone deacetylase activity (H3-K14 specific)-IEA-  
GO:0033558protein deacetylase activity-IMP23867755  
GO:0042826histone deacetylase binding-IPI23867755  
GO:0044212transcription regulatory region DNA bindingcontributes_toIDA19351956  
GO:0046872metal ion binding-IEA-  
GO:0070491repressing transcription factor binding-IPI12242305  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IDA16236793  
GO:0000122negative regulation of transcription by RNA polymerase II-IMP10983972  19351956  23867755  
GO:0006325chromatin organization-TAS12711221  
GO:0006338chromatin remodeling-TAS10220385  
GO:0006342chromatin silencing-TAS10869435  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006476protein deacetylation-IMP23867755  
GO:0006954inflammatory response-TAS12711221  
GO:0010830regulation of myotube differentiation-ISS-  
GO:0010832negative regulation of myotube differentiation-IMP10983972  11081517  
GO:0014823response to activity-IEA-  
GO:0016575histone deacetylation-IDA10869435  
GO:0030182neuron differentiation-IEA-  
GO:0030183B cell differentiation-TAS12711221  
GO:0032869cellular response to insulin stimulus-NAS18184930  
GO:0040029regulation of gene expression, epigenetic-IMP24413532  
GO:0042113B cell activation-TAS12711221  
GO:0042220response to cocaine-IEA-  
GO:0043393regulation of protein binding-IMP19071119  
GO:0045892negative regulation of transcription, DNA-templated-TAS12711221  
GO:0045944positive regulation of transcription by RNA polymerase II-IMP19071119  
GO:0051091positive regulation of DNA-binding transcription factor activity-IMP19071119  
GO:0070932histone H3 deacetylation-IEA-  
GO:0071222cellular response to lipopolysaccharide-IEA-  
GO:0090051negative regulation of cell migration involved in sprouting angiogenesis-IMP19351956  
GO:2000615regulation of histone H3-K9 acetylationNOTIMP23867755  
GO ID GO Term Qualifier Evidence PubMed
GO:0000118histone deacetylase complex-TAS12711221  
GO:0005634nucleus-IDA10869435  11081517  23867755  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IDA10869435  11081517  
GO:0005794Golgi apparatus-IDA-  
GO:0005829cytosol-IDA-  
GO:0016607nuclear speck-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1257604PIP3 activates AKT signalingIEA
R-HSA-157118Signaling by NOTCHIEA
R-HSA-162582Signal TransductionIEA
R-HSA-1643685DiseaseTAS
R-HSA-1980143Signaling by NOTCH1IEA
R-HSA-2122947NOTCH1 Intracellular Domain Regulates TranscriptionIEA
R-HSA-2644602Signaling by NOTCH1 PEST Domain Mutants in CancerTAS
R-HSA-2644603Signaling by NOTCH1 in CancerTAS
R-HSA-2644606Constitutive Signaling by NOTCH1 PEST Domain MutantsTAS
R-HSA-2894858Signaling by NOTCH1 HD+PEST Domain Mutants in CancerTAS
R-HSA-2894862Constitutive Signaling by NOTCH1 HD+PEST Domain MutantsTAS
R-HSA-5663202Diseases of signal transductionTAS
R-HSA-6807070PTEN RegulationIEA
R-HSA-8943724Regulation of PTEN gene transcriptionIEA
R-HSA-9006925Intracellular signaling by second messengersIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29109977Prior alcohol use enhances vulnerability to compulsive cocaine self-administration by promoting degradation of HDAC4 and HDAC5. (2017 Nov)Griffin EA JrSci Adv
22243740Regulated shuttling of the histone deacetylase HDAC5 to the nucleus may put a brake on cocaine addiction. (2012 Jan 12)West AENeuron