Gene: FARP1

10160
CDEP|FARP1-IT1|PLEKHC2|PPP1R75
FERM, ARH/RhoGEF and pleckstrin domain protein 1
protein-coding
13q32.2
Ensembl:ENSG00000152767 MIM:602654 Vega:OTTHUMG00000017248 UniprotKB:Q9Y4F1
NC_000013.11
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.365e-2 (AD)  4.236e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2772354chr13:98383634 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LRP10.86
RXRA0.843
ATN10.841
MRAS0.832
MLEC0.825
CLU0.824
WDR60.824
REPIN10.822
MXD40.816
TRIM80.815

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.694
OR4F29-0.64
OR6C74-0.302
CLEC6A-0.252
CETP-0.246
CHP2-0.232
CTNNA3-0.228
GADL1-0.224
AKR1B15-0.209
KRTAP4-3-0.208

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0067181,12-benzoperylene"1,12-benzoperylene results in decreased expression of FARP1 mRNA"26377693
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of FARP1 mRNA"28903501
C0152621,6-hexamethylene diisocyanate"1,6-hexamethylene diisocyanate results in increased methylation of FARP1 gene"25445006
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane affects the expression of FARP1 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FARP1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FARP1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FARP1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FARP1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of FARP1 mRNA21420995
D000082AcetaminophenAcetaminophen results in increased expression of FARP1 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of FARP1 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of FARP1 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of FARP1 mRNA19770486
C547126AZM551248AZM551248 results in increased expression of FARP1 mRNA22323515
C030935benz(a)anthracenebenz(a)anthracene results in decreased expression of FARP1 mRNA26377693
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of FARP1 mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of FARP1 mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of FARP1 mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of FARP1 gene25435355
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of FARP1 mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of FARP1 mRNA19770486
D004958EstradiolEstradiol inhibits the reaction [hydroxytamoxifen results in increased expression of FARP1 mRNA]16849584
D004958EstradiolEstradiol results in decreased expression of FARP1 mRNA20068009
C006780bisphenol Abisphenol A results in decreased expression of FARP1 mRNA22576693
C006780bisphenol Abisphenol A results in increased methylation of FARP1 gene22576693
C006780bisphenol Abisphenol A affects the methylation of FARP1 promoter27334623
C006780bisphenol Abisphenol A results in decreased expression of FARP1 mRNA26063408
C006780bisphenol Abisphenol A affects the expression of FARP1 mRNA25181051
C006780bisphenol Abisphenol A affects the methylation of FARP1 promoter27415467
C006780bisphenol Abisphenol A results in increased methylation of FARP1 gene28505145
C013418bromfenacoumbromfenacoum results in increased expression of FARP1 protein28903499
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of FARP1 mRNA15336504
C018475butyraldehydebutyraldehyde results in decreased expression of FARP1 mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of FARP1 mRNA26472689
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of FARP1 mRNA27858113
C018021cobaltous chloridecobaltous chloride results in decreased expression of FARP1 mRNA19320972
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of FARP1 mRNA20971185
D003300Copper[ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of FARP1 mRNA15467011
D019327Copper SulfateCopper Sulfate results in decreased expression of FARP1 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of FARP1 mRNA25562108|2798913
C000944dicrotophosdicrotophos results in increased expression of FARP1 mRNA28302478
D004041Dietary FatsDietary Fats results in decreased expression of FARP1 mRNA25016146
D004237DiuronDiuron results in decreased expression of FARP1 mRNA21551480
C118739entinostatentinostat results in decreased expression of FARP1 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FARP1 mRNA"27188386
D004397FonofosFonofos results in increased methylation of FARP1 promoter22847954
C069837fullerene C60fullerene C60 results in increased expression of FARP1 mRNA19167457
C070081fulvestrantfulvestrant inhibits the reaction [hydroxytamoxifen results in increased expression of FARP1 mRNA]16849584
D019833GenisteinGenistein results in increased expression of FARP1 mRNA20884965
D017313FenretinideFenretinide results in decreased expression of FARP1 mRNA28973697
D017313FenretinideFenretinide results in increased expression of FARP1 mRNA28973697
C475919hydroxytamoxifenESR2 protein inhibits the reaction [hydroxytamoxifen results in increased expression of FARP1 mRNA]16849584
C475919hydroxytamoxifenEstradiol inhibits the reaction [hydroxytamoxifen results in increased expression of FARP1 mRNA]16849584
C475919hydroxytamoxifenfulvestrant inhibits the reaction [hydroxytamoxifen results in increased expression of FARP1 mRNA]16849584
C475919hydroxytamoxifenhydroxytamoxifen results in increased expression of FARP1 mRNA16849584
D007545IsoproterenolIsoproterenol results in increased expression of FARP1 mRNA21335049
C410337K 7174K 7174 results in decreased expression of FARP1 mRNA24086573
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of FARP1 mRNA23103053
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of FARP1 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of FARP1 mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of FARP1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of FARP1 mRNA"25554681
D009532NickelNickel results in decreased expression of FARP1 mRNA25583101
C028007nickel monoxidenickel monoxide results in increased expression of FARP1 mRNA19167457
C029938nickel sulfatenickel sulfate results in increased expression of FARP1 mRNA16780908
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of FARP1 mRNA20971185
D010278ParathionParathion results in increased methylation of FARP1 promoter22847954
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in decreased expression of FARP1 mRNA]19482888
D010634PhenobarbitalPhenobarbital results in decreased expression of FARP1 mRNA19482888
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of FARP1 mRNA28903501
D011441PropylthiouracilPropylthiouracil results in increased expression of FARP1 mRNA24780913
D011794QuercetinQuercetin results in decreased expression of FARP1 mRNA21632981
D012643SeleniumSelenium results in increased expression of FARP1 mRNA19244175
D012822Silicon DioxideSilicon Dioxide results in increased expression of FARP1 mRNA23221170
C017947sodium arsenitesodium arsenite affects the methylation of FARP1 gene28589171
D018038Sodium SeleniteSodium Selenite results in decreased expression of FARP1 mRNA18175754
D012999SomanSoman results in increased expression of FARP1 mRNA19281266
C012568terbufosterbufos results in increased methylation of FARP1 promoter22847954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of FARP1 mRNA26290441
C012589trichostatin Atrichostatin A results in decreased expression of FARP1 mRNA24935251
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of FARP1 mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of FARP1 mRNA"26179874
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FARP1 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of FARP1 mRNA23179753|2597931
D014635Valproic AcidValproic Acid results in decreased expression of FARP1 mRNA24383497|2627250
D014635Valproic AcidValproic Acid results in increased methylation of FARP1 gene29154799
C025643vinclozolinvinclozolin affects the expression of FARP1 mRNA19015723
C025643vinclozolinvinclozolin results in decreased expression of FARP1 mRNA23034163
D024483Vitamin K 3Vitamin K 3 affects the expression of FARP1 mRNA20044591

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005089Rho guanyl-nucleotide exchange factor activity-TAS9425278  
GO:0008092cytoskeletal protein binding-IEA-  
GO:0030676Rac guanyl-nucleotide exchange factor activity-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007416synapse assembly-ISS-  
GO:0010923negative regulation of phosphatase activity-IDA19389623  
GO:0035023regulation of Rho protein signal transduction-IEA-  
GO:0048813dendrite morphogenesis-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-ISS-  
GO:0005856cytoskeleton-IEA-  
GO:0030054cell junction-IEA-  
GO:0030175filopodium-IEA-  
GO:0030425dendrite-ISS-  
GO:0031234extrinsic component of cytoplasmic side of plasma membrane-ISS-  
GO:0043197dendritic spine-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal