Gene: MEI4

101928601
-
meiotic double-stranded break formation protein 4
protein-coding
6q14.1
Ensembl:ENSG00000269964 Vega:OTTHUMG00000153472 UniprotKB:A8MW99
NC_000006.12
SNP Mapped
OD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7761742chr6:77710715 (GRCh38.p7)T>Copioid dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ABCA130.639
TMEM255A0.597
ARHGEF350.595
DPPA40.589
CD3G0.576
OR10H30.572
TRIM64C0.571
CHODL0.562
G6PC20.562
KLRF10.561

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NEUROD2-0.431
PKDCC-0.417
PSPN-0.416
TMEM81-0.408
SOHLH1-0.404
CPNE9-0.397
DNASE1L2-0.393
CA7-0.391
EMX1-0.391
SDK2-0.389

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D020106AcrylamideAcrylamide results in decreased expression of MEI4 mRNA28959563
C006780bisphenol Abisphenol A results in decreased expression of MEI4 mRNA25181051
D003471CuprizoneCuprizone results in increased expression of MEI4 mRNA26577399
D011441PropylthiouracilPropylthiouracil results in increased expression of MEI4 mRNA24780913
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of MEI4 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0006310DNA recombination-IEA-  
GO:0007129synapsis-ISS-  
GO:0007283spermatogenesis-ISS-  
GO:0042138meiotic DNA double-strand break formation-ISS-  
GO:0048477oogenesis-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000800lateral element-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

There is no Interaction data for this gene.

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal