Gene: GPHN

10243
GEPH|GPH|GPHRYN|HKPX1|MOCODC
gephyrin
protein-coding
14q23.3-q24.1
Ensembl:ENSG00000171723 MIM:603930 Vega:OTTHUMG00000029785 UniprotKB:Q9NQX3
NG_008875.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.770e-2 (AD)  1.768e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7159831chr14:66562315 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
AGK0.955
DNM1L0.954
DDX250.949
VPS33B0.947
C2CD50.945
GSTA40.944
GPRASP10.943
MRPS270.943
KLHL420.943
SLC9A60.942

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.544
OR4F29-0.496
CSAG1-0.448
PGF-0.445
RAI14-0.441
CCDC102A-0.44
CNN2-0.439
TFPI2-0.431
MTRNR2L6-0.422
RUNX3-0.421

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01942Formic AcidSmall Molecule64-18-6Approved|Experimental|InvestigationalTarget
DB03366ImidazoleSmall Molecule288-32-4Experimental|InvestigationalTarget
DB03766Propanoic AcidSmall Molecule79-09-4ExperimentalTarget
ID Drug Name Action PubMed
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in decreased expression of GPHN mRNA"20406850
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of GPHN mRNA"21346803
D000082AcetaminophenAcetaminophen affects the expression of GPHN mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 affects the expression of GPHN protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of GPHN gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of GPHN mRNA19770486
D001280AtrazineAtrazine results in decreased expression of GPHN mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of GPHN mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of GPHN mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of GPHN mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of GPHN mRNA"19150397|2001819
C044887beta-methylcholinebeta-methylcholine affects the expression of GPHN mRNA21179406
C006780bisphenol Abisphenol A results in increased expression of GPHN protein28089772
C006780bisphenol Abisphenol A results in increased expression of GPHN mRNA25181051
D000069286BortezomibBortezomib results in decreased expression of GPHN mRNA20977926
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of GPHN mRNA25596134
D002220CarbamazepineCarbamazepine affects the expression of GPHN mRNA25979313
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of GPHN mRNA17484886
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of GPHN mRNA27339419
C054133casticincasticin results in decreased expression of GPHN mRNA28444820
C026690cerous chloridecerous chloride results in increased expression of GPHN mRNA23573234
C004656chloroacetaldehydechloroacetaldehyde results in decreased expression of GPHN mRNA25596134
D002995Clofibric Acid[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of GPHN mRNA17602206
D003474CurcuminCurcumin affects the expression of GPHN mRNA18539377
D016572CyclosporineCyclosporine results in decreased expression of GPHN mRNA20106945
D016572CyclosporineCyclosporine results in increased expression of GPHN mRNA25562108
D016572CyclosporineCyclosporine results in decreased expression of GPHN mRNA25596134
C014347decitabinedecitabine results in decreased methylation of GPHN gene27923600
D002945CisplatinCisplatin results in decreased expression of GPHN mRNA19561079|2559613
D002945CisplatinCisplatin results in increased expression of GPHN mRNA27392435
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of GPHN mRNA17602206
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of GPHN mRNA25374375
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in increased methylation of GPHN promoter25374375
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of GPHN mRNA19638242
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of GPHN mRNA"22485181
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of GPHN protein23301498
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of GPHN mRNA22079256
D000431EthanolEthanol results in increased expression of GPHN mRNA15353170
D011345FenofibrateFenofibrate results in increased expression of GPHN mRNA25596134
D011345FenofibrateFenofibrate results in increased expression of GPHN mRNA25596134
D005485FlutamideFlutamide results in decreased expression of GPHN mRNA24793618
D005897GlafenineGlafenine results in decreased expression of GPHN mRNA24136188
C010178heliotrineheliotrine results in decreased expression of GPHN mRNA26100227
D017313FenretinideFenretinide results in decreased expression of GPHN mRNA28973697
C051890irinotecanirinotecan results in decreased expression of GPHN mRNA20097248
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of GPHN mRNA"24972896
D008687MetforminMetformin results in increased expression of GPHN mRNA25596134
D008731MethoxychlorMethoxychlor results in increased methylation of GPHN gene23303685
D008767Methylmercury CompoundsMethylmercury Compounds results in decreased expression of GPHN protein26558463
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of GPHN mRNA"25620056
C029938nickel sulfatenickel sulfate results in decreased expression of GPHN mRNA22714537
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of GPHN mRNA25729387
D010100OxygenOxygen deficiency results in decreased expression of GPHN mRNA25596134
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of GPHN mRNA25374375
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in increased methylation of GPHN promoter25374375
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of GPHN mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of GPHN mRNA18445702
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of GPHN mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of GPHN mRNA22079256
D011192Potassium DichromatePotassium Dichromate results in decreased expression of GPHN mRNA23608068
D011763Pyrrolizidine AlkaloidsPyrrolizidine Alkaloids results in decreased expression of GPHN mRNA26100227
C009237senecioninesenecionine results in decreased expression of GPHN mRNA26100227
C009238senkirkinesenkirkine results in decreased expression of GPHN mRNA26100227
C017947sodium arsenitesodium arsenite results in increased expression of GPHN protein19072884
C016104sodium bichromatesodium bichromate results in decreased expression of GPHN mRNA25993096
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GPHN mRNA21570461|2468072
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of GPHN mRNA21215274
D013853ThioacetamideThioacetamide results in decreased expression of GPHN mRNA23411599
D014050TolueneToluene affects the expression of GPHN mRNA21827849
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of GPHN mRNA25729387
D019772TopotecanTopotecan results in decreased expression of GPHN mRNA25729387
C057693troglitazonetroglitazone results in decreased expression of GPHN mRNA28973697
D014520UrethaneUrethane results in increased expression of GPHN mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of GPHN mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of GPHN mRNA23179753|2915479
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of GPHN gene25560391
C029297vinylidene chloridevinylidene chloride results in decreased expression of GPHN mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI21094642  26613940  27173435  
GO:0005524ATP binding-IEA-  
GO:0008940nitrate reductase activity-IMP9990024  
GO:0043546molybdopterin cofactor binding-IDA9990024  
GO:0046872metal ion binding-IEA-  
GO:0061598molybdopterin adenylyltransferase activity-IBA21873635  
GO:0061599molybdopterin molybdotransferase activity-IBA21873635  
GO:0061599molybdopterin molybdotransferase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006777Mo-molybdopterin cofactor biosynthetic process-IBA21873635  
GO:0007529establishment of synaptic specificity at neuromuscular junction-IBA21873635  
GO:0010038response to metal ion-IMP9990024  
GO:0018315molybdenum incorporation into molybdenum-molybdopterin complex-IBA21873635  
GO:0032324molybdopterin cofactor biosynthetic process-IBA21873635  
GO:0032324molybdopterin cofactor biosynthetic process-IDA26613940  
GO:0032324molybdopterin cofactor biosynthetic process-IMP9990024  
GO:0032324molybdopterin cofactor biosynthetic process-TAS-  
GO:0055114oxidation-reduction process-IEA-  
GO:0072579glycine receptor clustering-IBA21873635  
GO:0097112gamma-aminobutyric acid receptor clustering-IBA21873635  
GO:0097112gamma-aminobutyric acid receptor clustering-IDA26613940  
GO:0098970postsynaptic neurotransmitter receptor diffusion trapping-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005829cytosol-IBA21873635  
GO:0005856cytoskeleton-IEA-  
GO:0005886plasma membrane-TAS-  
GO:0030054cell junction-IEA-  
GO:0030425dendrite-IBA21873635  
GO:0030425dendrite-IDA26613940  
GO:0045211postsynaptic membrane-IBA21873635  
GO:0045211postsynaptic membrane-IDA26613940  
GO:0099572postsynaptic specialization-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-196849Metabolism of water-soluble vitamins and cofactorsTAS
R-HSA-196854Metabolism of vitamins and cofactorsTAS
R-HSA-947581Molybdenum cofactor biosynthesisTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal