Gene: LAMC3

10319
OCCM
laminin subunit gamma 3
protein-coding
9q34.12
Ensembl:ENSG00000050555 MIM:604349 Vega:OTTHUMG00000020819 UniprotKB:Q9Y6N6
NG_029800.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.139e-1 (AD)  2.939e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs58477043chr9:131051366-131051382 (GRCh38.p7)delT / dupT / dupTT / dupTTTalcohol dependenceIndel(Insertion and Deletion)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
COL4A30.789
NDUFA4L20.717
CD2480.716
PLEKHG20.713
COL4A40.712
TFPI0.7
MRC20.698
DCN0.698
ARHGAP290.697
FN10.691

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
C1orf53-0.448
GPR19-0.412
GLRA3-0.407
GGH-0.398
MUM1L1-0.386
BAG2-0.384
KCNG1-0.38
PPIL6-0.376
HIST3H2A-0.374
C10orf111-0.372

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of LAMC3 mRNA"27291303
C0131862,3-pentanedione"2,3-pentanedione results in decreased expression of LAMC3 mRNA"25710175
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of LAMC3 mRNA"21346803
C0179063-dinitrobenzene3-dinitrobenzene results in increased expression of LAMC3 mRNA21983209
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LAMC3 mRNA"27188386
C0022024-oxoretinoic acid4-oxoretinoic acid results in increased expression of LAMC3 mRNA15982314
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LAMC3 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of LAMC3 mRNA22230336
C103303alitretinoinalitretinoin results in increased expression of LAMC3 mRNA15982314
D001280AtrazineAtrazine results in decreased expression of LAMC3 mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to LAMC3 promoter]19654925
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of LAMC3 mRNA22228805
D004958Estradiol[Estradiol co-treated with Plant Preparations] results in decreased expression of LAMC3 mRNA26945725
D004958EstradiolEstradiol results in decreased expression of LAMC3 mRNA26945725
C006780bisphenol Abisphenol A results in decreased expression of LAMC3 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of LAMC3 gene28505145
C584509C646 compoundC646 compound results in increased expression of LAMC3 mRNA26191083
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of LAMC3 mRNA24763279
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of LAMC3 mRNA23640034
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of LAMC3 mRNA27392435
D002945CisplatinCisplatin results in increased expression of LAMC3 mRNA27392435
D004317DoxorubicinDoxorubicin results in decreased expression of LAMC3 mRNA15033991
C118739entinostatentinostat results in increased expression of LAMC3 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LAMC3 mRNA"27188386
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of LAMC3 mRNA24763279
C492448ICG 001ICG 001 results in increased expression of LAMC3 mRNA26191083
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of LAMC3 mRNA27392435
D007854LeadLead results in increased expression of LAMC3 mRNA19921347
D037742Nanotubes, Carbon"Nanotubes, Carbon analog affects the expression of LAMC3 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of LAMC3 mRNA"25554681
D028321Plant Preparations[Estradiol co-treated with Plant Preparations] results in decreased expression of LAMC3 mRNA26945725
D011374ProgesteroneProgesterone results in increased expression of LAMC3 mRNA22238285
C502851quinocetonequinocetone results in increased expression of LAMC3 mRNA27046791
D015474IsotretinoinIsotretinoin results in increased expression of LAMC3 mRNA15982314
C017947sodium arsenitesodium arsenite affects the methylation of LAMC3 gene28589171
D014212TretinoinTretinoin metabolite results in increased expression of LAMC3 mRNA15982314
D014212TretinoinTretinoin results in increased expression of LAMC3 mRNA15982314
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of LAMC3 mRNA29024780
D014635Valproic AcidValproic Acid affects the expression of LAMC3 mRNA25979313
D014635Valproic AcidValproic Acid results in increased methylation of LAMC3 gene29154799
C025643vinclozolinvinclozolin results in increased methylation of LAMC3 promoter22570695

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005198structural molecule activity-TAS10225960  
GO ID GO Term Qualifier Evidence PubMed
GO:0000904cell morphogenesis involved in differentiation-IEA-  
GO:0007155cell adhesion-IEA-  
GO:0007601visual perception-IEA-  
GO:0014002astrocyte development-IEA-  
GO:0030198extracellular matrix organization-TAS-  
GO:0060041retina development in camera-type eye-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005604basement membrane-IEA-  
GO:0016020membrane-TAS10225960  
GO:0031012extracellular matrix-TAS10225960  
KEGG ID KEGG Term
hsa04510Focal adhesion
hsa04512ECM-receptor interaction
hsa05145Toxoplasmosis
hsa05146Amoebiasis
hsa05200Pathways in cancer
hsa05222Small cell lung cancer
Reactome ID Reactome Term Evidence
R-HSA-1474244Extracellular matrix organizationIEA
R-HSA-1474244Extracellular matrix organizationTAS
R-HSA-162582Signal TransductionTAS
R-HSA-3000157Laminin interactionsIEA
R-HSA-3000157Laminin interactionsTAS
R-HSA-3000171Non-integrin membrane-ECM interactionsIEA
R-HSA-6806834Signaling by METTAS
R-HSA-8874081MET activates PTK2 signalingTAS
R-HSA-8875878MET promotes cell motilityTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal