Gene: CLEC4M

10332
CD209L|CD299|DC-SIGN2|DC-SIGNR|DCSIGNR|HP10347|L-SIGN|LSIGN
C-type lectin domain family 4 member M
protein-coding
19p13.2
Ensembl:ENSG00000104938 MIM:605872 Vega:OTTHUMG00000182432 UniprotKB:Q9H2X3
NG_029190.1
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
1   
7.167e-1 (AD)  8.066e-1 (ND)   (Frontal_Cortex)
3.983e-1 (AD)  3.742e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs3745376chr19:7768804 (GRCh38.p7)G>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SYT20.482
PLEKHD10.454
NKX6-30.434
NEFH0.428
PHOSPHO10.422
RAB370.42
KCNAB30.414
COL5A20.414
VAMP10.412
ANK10.412

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LRAT-0.317
UHRF1-0.306
FITM1-0.3
BAG3-0.299
TIPARP-0.298
CSF1-0.297
GEM-0.29
ZC3H12A-0.29
MORC4-0.287
SERPINH1-0.286

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of CLEC4M gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of CLEC4M mRNA23630614
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CLEC4M mRNA26001963
D004958EstradiolEstradiol affects the expression of CLEC4M mRNA14699072
D004958EstradiolEstradiol promotes the reaction [ESR2 protein affects the expression of CLEC4M mRNA]20404318
C006780bisphenol Abisphenol A results in decreased expression of CLEC4M mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of CLEC4M gene28505145
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of CLEC4M promoter22457795
D017313FenretinideFenretinide results in decreased expression of CLEC4M mRNA28973697
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of CLEC4M mRNA23103053
D011374ProgesteroneProgesterone results in decreased expression of CLEC4M mRNA23012394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CLEC4M mRNA22574217
C057693troglitazonetroglitazone results in increased expression of CLEC4M mRNA28973697

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001618virus receptor activity-IDA15496474  
GO:0001618virus receptor activity-IMP15496474  
GO:0005515protein binding-IPI16246332  
GO:0005537mannose binding-IEA-  
GO:0030246carbohydrate binding-NAS11337487  
GO:0030369ICAM-3 receptor activity-NAS11257134  
GO:0038023signaling receptor activity-NAS11257134  
GO:0042605peptide antigen binding-NAS11337487  
GO:0046790virion binding-TAS11337487  
GO:0046872metal ion binding-IEA-  
GO:0048306calcium-dependent protein binding-IPI12609975  
GO ID GO Term Qualifier Evidence PubMed
GO:0002250adaptive immune response-IEA-  
GO:0006897endocytosis-IEA-  
GO:0007159leukocyte cell-cell adhesion-NAS11337487  
GO:0009988cell-cell recognition-TAS11337487  
GO:0019048modulation by virus of host morphology or physiology-TAS11337487  
GO:0019062virion attachment to host cell-TAS11337487  
GO:0019079viral genome replication-NAS11337487  
GO:0019882antigen processing and presentation-NAS11337487  
GO:0035556intracellular signal transduction-NAS11337487  
GO:0045087innate immune response-IEA-  
GO:0046718viral entry into host cell-IEA-  
GO:0046968peptide antigen transport-NAS11337487  
GO:0075733intracellular transport of virus-TAS11337487  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IEA-  
GO:0005737cytoplasm-NAS11337487  
GO:0005887integral component of plasma membrane-TAS10072769  
GO:0016020membrane-TAS11337487  
GO:0043657host cell-IEA-  
KEGG ID KEGG Term
hsa04145Phagosome
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24046282Analyses of synovial tissues from arthritic and protected congenic rat strains reveal a new core set of genes associated with disease severity. (2013 Nov 15)Brenner MPhysiol Genomics