Gene: CORO2B

10391
CLIPINC
coronin 2B
protein-coding
15q23
Ensembl:ENSG00000103647 MIM:605002 Vega:OTTHUMG00000133288 UniprotKB:Q9UQ03
NC_000015.10
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.259e-1 (AD)  4.593e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs17279860chr15:68726620 (GRCh38.p7)A>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg02793162chr15:68958534CORO2B1.200e-8Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ATG9A0.953
MAPT0.953
RUSC20.95
FAIM20.95
CLSTN10.949
FAM171A10.948
ATP6V0A10.946
DEF80.945
TYRO30.945
WIPI20.94

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.675
OR4F29-0.636
TFPI2-0.526
SIX1-0.476
KCNJ15-0.472
IL18RAP-0.472
KLRB1-0.468
SLAMF6-0.467
KLRF1-0.464
CD48-0.453

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of CORO2B mRNA"21394737
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of CORO2B mRNA"19114083
D020106AcrylamideAcrylamide results in increased expression of CORO2B mRNA28959563
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of CORO2B mRNA21298039
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of CORO2B mRNA24449571
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CORO2B mRNA20106945|2163298
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CORO2B mRNA"20382639
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of CORO2B mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of CORO2B mRNA25181051
C018475butyraldehydebutyraldehyde results in increased expression of CORO2B mRNA26079696
D003300CopperCopper deficiency results in increased expression of CORO2B mRNA26033743
D016572CyclosporineCyclosporine results in increased expression of CORO2B mRNA21632981|2556210
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of CORO2B mRNA28628672
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of CORO2B mRNA27392435
D002945CisplatinCisplatin results in decreased expression of CORO2B mRNA27392435
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of CORO2B mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of CORO2B mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CORO2B mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of CORO2B mRNA23550701
D017313FenretinideFenretinide results in decreased expression of CORO2B mRNA28973697
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of CORO2B mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of CORO2B mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of CORO2B mRNA27392435
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of CORO2B mRNA"20188158
D009532NickelNickel results in decreased expression of CORO2B mRNA25583101
C029938nickel sulfatenickel sulfate results in decreased expression of CORO2B mRNA22714537
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of CORO2B mRNA26705709
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of CORO2B mRNA22714537
D011441PropylthiouracilPropylthiouracil results in decreased expression of CORO2B mRNA24780913
D011794QuercetinQuercetin results in increased expression of CORO2B mRNA21632981
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of CORO2B mRNA25895662
D013629TamoxifenTamoxifen affects the expression of CORO2B mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CORO2B mRNA21570461|2637764
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CORO2B mRNA17942748
D014212TretinoinTretinoin results in increased expression of CORO2B mRNA23724009
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of CORO2B mRNA29024780
D014520UrethaneUrethane results in decreased expression of CORO2B mRNA28818685
D014635Valproic AcidValproic Acid results in increased expression of CORO2B mRNA19101580
D014635Valproic AcidValproic Acid affects the expression of CORO2B mRNA17292431
D014638VanadatesVanadates results in increased expression of CORO2B mRNA22714537
D001335Vehicle EmissionsVehicle Emissions affects the methylation of CORO2B gene25560391
C111237vorinostatvorinostat results in decreased expression of CORO2B mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003779actin binding-NAS10224093  
GO:0005515protein binding-IPI25416956  
GO ID GO Term Qualifier Evidence PubMed
GO:0030036actin cytoskeleton organization-NAS10224093  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IEA-  
GO:0015629actin cytoskeleton-NAS10224093  
GO:0016020membrane-NAS10224093  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal