Gene: NOD1

10392
CARD4|CLR7.1|NLRC1
nucleotide binding oligomerization domain containing 1
protein-coding
7p14.3
Ensembl:ENSG00000106100 MIM:605980 Vega:OTTHUMG00000023923 UniprotKB:Q9Y239
NG_013025.1
PubMed|SNP Mapped
ND|AD
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.639e-1 (AD)  6.984e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2037955chr7:30472333 (GRCh38.p7)C>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DAB20.814
APOL30.808
TRIM50.806
IL18BP0.802
SP1000.8
SP140L0.799
NLRC50.796
TRIM220.794
CFLAR0.793
STK100.793

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KCNIP3-0.378
MYADML2-0.354
CPLX3-0.353
WNT7A-0.347
BCL11A-0.341
NEUROD6-0.341
TMEM179-0.336
ABCC12-0.324
RTN4R-0.321
ASPDH-0.316

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5240423,5-bis(2-fluorobenzylidene)piperidin-4-one"3,5-bis(2-fluorobenzylidene)piperidin-4-one inhibits the reaction [Oxygen deficiency results in increased expression of NOD1 mRNA]"23452621
C0909424-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [NOD1 protein results in increased secretion of CXCL8 protein]16365441
D000082AcetaminophenAcetaminophen results in increased expression of NOD1 mRNA22230336
D020106AcrylamideAcrylamide results in decreased expression of NOD1 mRNA28959563
D020106AcrylamideAcrylamide results in increased expression of NOD1 mRNA28959563
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of NOD1 mRNA24449571
D001280AtrazineAtrazine results in decreased expression of NOD1 mRNA22982499
C547126AZM551248AZM551248 results in increased expression of NOD1 mRNA22323515
C004456beauvericinbeauvericin results in increased expression of NOD1 mRNA29203277
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of NOD1 mRNA22228805
C006780bisphenol Abisphenol A results in decreased expression of NOD1 mRNA25270620
C006780bisphenol Abisphenol A affects the expression of NOD1 mRNA25181051
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in decreased expression of NOD1 mRNA25270620
D003471CuprizoneCuprizone results in decreased expression of NOD1 mRNA26577399
D003474CurcuminCurcumin inhibits the reaction [Oxygen deficiency results in increased expression of NOD1 mRNA]23452621
C014347decitabinedecitabine affects the expression of NOD1 mRNA23300844
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of NOD1 mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of NOD1 mRNA21266533
D002945CisplatinCisplatin affects the expression of NOD1 mRNA23300844
D002945CisplatinCisplatin results in increased expression of NOD1 mRNA21278888
D002945CisplatinCisplatin results in increased expression of NOD1 protein21278888
D002945CisplatinCisplatin results in increased expression of NOD1 mRNA21151649
D004052Diethylnitrosamine[Piperonyl Butoxide co-treated with Diethylnitrosamine] affects the methylation of NOD1 gene23968726
D004317DoxorubicinDoxorubicin affects the methylation of NOD1 gene28962528
C034330FK 156FK 156 binds to and results in increased activity of NOD1 protein16299289
C039537FK 565FK 565 binds to and results in increased activity of NOD1 protein16299289
D019833GenisteinGenistein inhibits the reaction [Oxygen deficiency results in increased expression of NOD1 mRNA]23452621
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of NOD1 mRNA17183730
C008261lead acetatelead acetate results in decreased expression of NOD1 mRNA25270620
C433788lipopolysaccharide, E. coli O26-B6"lipopolysaccharide, E. coli O26-B6 results in decreased expression of NOD1 mRNA"23090859
C433788lipopolysaccharide, E. coli O26-B6"nickel chloride inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in decreased expression of NOD1 mRNA]"23090859
C482199lipopolysaccharide, E coli O55-B5"[lipopolysaccharide, E coli O55-B5 co-treated with FSHB protein] results in decreased expression of NOD1 mRNA"22771338
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of NOD1 mRNA24056979
D008070Lipopolysaccharidesmethyldithiocarbamate inhibits the reaction [Lipopolysaccharides results in increased expression of NOD1 mRNA]24056979
D008628MercuryMercury results in decreased expression of NOD1 mRNA19937285
D008727MethotrexateMethotrexate results in decreased expression of NOD1 mRNA24449571
C008435methyldithiocarbamatemethyldithiocarbamate inhibits the reaction [Lipopolysaccharides results in increased expression of NOD1 mRNA]24056979
D009532NickelNickel results in increased expression of NOD1 mRNA24768652|2558310
C022838nickel chloride"nickel chloride inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in decreased expression of NOD1 mRNA]"23090859
D010100Oxygen"3,5-bis(2-fluorobenzylidene)piperidin-4-one inhibits the reaction [Oxygen deficiency results in increased expression of NOD1 mRNA]"23452621
D010100OxygenCurcumin inhibits the reaction [Oxygen deficiency results in increased expression of NOD1 mRNA]23452621
D010100OxygenGenistein inhibits the reaction [Oxygen deficiency results in increased expression of NOD1 mRNA]23452621
D010100OxygenOxygen deficiency results in increased expression of NOD1 mRNA23452621
D010100OxygenPlant Extracts inhibits the reaction [Oxygen deficiency results in increased expression of NOD1 mRNA]23452621
D010100Oxygenresveratrol inhibits the reaction [Oxygen deficiency results in increased expression of NOD1 mRNA]23452621
D010882Piperonyl Butoxide[Piperonyl Butoxide co-treated with Diethylnitrosamine] affects the methylation of NOD1 gene23968726
D010936Plant ExtractsPlant Extracts inhibits the reaction [Oxygen deficiency results in increased expression of NOD1 mRNA]23452621
D011441PropylthiouracilPropylthiouracil results in decreased expression of NOD1 mRNA24780913
C059514resveratrolresveratrol inhibits the reaction [Oxygen deficiency results in increased expression of NOD1 mRNA]23452621
D013629TamoxifenTamoxifen results in increased expression of NOD1 mRNA25123088
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NOD1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to NOD1 promoter]19654925
D014241TrichloroethyleneTrichloroethylene results in decreased expression of NOD1 mRNA25549359
D014520UrethaneUrethane results in increased expression of NOD1 mRNA28818685
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of NOD1 mRNA17183730
D014635Valproic AcidValproic Acid affects the expression of NOD1 mRNA17292431
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of NOD1 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI10329646  15107016  15657077  16083881  17054981  17420470  
19043560  19337385  20534456  23935490  25036637  
GO:0005524ATP binding-IEA-  
GO:0008656cysteine-type endopeptidase activator activity involved in apoptotic process-TAS10329646  
GO:0042802identical protein binding-IDA10329646  
GO:0042802identical protein binding-IPI18186648  
GO:0042803protein homodimerization activity-IPI18186648  
GO:0042834peptidoglycan binding-TAS15967716  
GO:0050700CARD domain binding-IDA10329646  
GO ID GO Term Qualifier Evidence PubMed
GO:0000187activation of MAPK activity-TAS-  
GO:0002606positive regulation of dendritic cell antigen processing and presentation-ISS-  
GO:0006915apoptotic process-IEA-  
GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process-IDA10329646  
GO:0006952defense response-TAS15967716  
GO:0006954inflammatory response-TAS15967716  
GO:0007165signal transduction-TAS15967716  
GO:0007254JNK cascade-TAS-  
GO:0009595detection of biotic stimulus-TAS15967716  
GO:0016045detection of bacterium-IDA15653568  
GO:0023052signaling-IBA21873635  
GO:0032731positive regulation of interleukin-1 beta production-IEA-  
GO:0032755positive regulation of interleukin-6 production-IEA-  
GO:0032760positive regulation of tumor necrosis factor production-IEA-  
GO:0035556intracellular signal transduction-IBA21873635  
GO:0035556intracellular signal transduction-IDA15653568  
GO:0042228interleukin-8 biosynthetic process-IDA15653568  
GO:0042742defense response to bacterium-IDA15653568  
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling-IDA10329646  
GO:0043280positive regulation of cysteine-type endopeptidase activity involved in apoptotic process-IDA10329646  
GO:0045087innate immune response-IEA-  
GO:0046330positive regulation of JNK cascade-IEA-  
GO:0050830defense response to Gram-positive bacterium-IEA-  
GO:0051000positive regulation of nitric-oxide synthase activity-IEA-  
GO:0051092positive regulation of NF-kappaB transcription factor activity-IDA17054981  19043560  
GO:0051092positive regulation of NF-kappaB transcription factor activity-TAS-  
GO:0051259protein complex oligomerization-TAS15967716  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IEA-  
GO:0070423nucleotide-binding oligomerization domain containing signaling pathway-TAS-  
GO:0070498interleukin-1-mediated signaling pathway-TAS-  
GO:0071225cellular response to muramyl dipeptide-IMP25093298  
GO:1901224positive regulation of NIK/NF-kappaB signaling-IMP25093298  
GO:1904417positive regulation of xenophagy-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasmCOLOCALIZES_WITHIBA21873635  
GO:0005737cytoplasm-IDA10329646  
GO:0005737cytoplasm-TAS15967716  
GO:0005829cytosol-TAS-  
GO:0016323basolateral plasma membrane-IDA19043560  
GO:0016324apical plasma membrane-IEA-  
KEGG ID KEGG Term
hsa04621NOD-like receptor signaling pathway
hsa05120Epithelial cell signaling in Helicobacter pylori infection
hsa05131Shigellosis
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-166016Toll Like Receptor 4 (TLR4) CascadeTAS
R-HSA-166058MyD88:Mal cascade initiated on plasma membraneTAS
R-HSA-166166MyD88-independent TLR4 cascade TAS
R-HSA-168138Toll Like Receptor 9 (TLR9) CascadeTAS
R-HSA-168142Toll Like Receptor 10 (TLR10) CascadeTAS
R-HSA-168164Toll Like Receptor 3 (TLR3) CascadeTAS
R-HSA-168176Toll Like Receptor 5 (TLR5) CascadeTAS
R-HSA-168179Toll Like Receptor TLR1:TLR2 CascadeTAS
R-HSA-168181Toll Like Receptor 7/8 (TLR7/8) CascadeTAS
R-HSA-168188Toll Like Receptor TLR6:TLR2 CascadeTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168249Innate Immune SystemIEA
R-HSA-168256Immune SystemTAS
R-HSA-168256Immune SystemIEA
R-HSA-168638NOD1/2 Signaling PathwayTAS
R-HSA-168638NOD1/2 Signaling PathwayIEA
R-HSA-168643Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathwaysTAS
R-HSA-168643Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathwaysIEA
R-HSA-168898Toll-Like Receptors CascadesTAS
R-HSA-181438Toll Like Receptor 2 (TLR2) CascadeTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-445989TAK1 activates NFkB by phosphorylation and activation of IKKs complexTAS
R-HSA-446652Interleukin-1 family signalingTAS
R-HSA-448424Interleukin-17 signalingTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-450294MAP kinase activationTAS
R-HSA-450302activated TAK1 mediates p38 MAPK activationTAS
R-HSA-450321JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1TAS
R-HSA-5688426DeubiquitinationTAS
R-HSA-5689896Ovarian tumor domain proteasesTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-9020702Interleukin-1 signalingTAS
R-HSA-937061TRIF(TICAM1)-mediated TLR4 signaling TAS
R-HSA-975138TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationTAS
R-HSA-975155MyD88 dependent cascade initiated on endosomeTAS
R-HSA-975871MyD88 cascade initiated on plasma membraneTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25968832Cigarette Smoke Modulates NOD1 Signal Pathway and Human beta Defensins Expression in Human Oral Mucosa. (2015)Qian YJCell Physiol Biochem
17030188TUCAN (CARD8) genetic variants and inflammatory bowel disease. (2006 Oct)McGovern DPGastroenterology
19587002NOD1 gene polymorphisms in relation to aggressive periodontitis. (2009 Aug)Loos BGInnate Immun
26550162NOD1 agonist iE-DAP reverses effects of cigarette smoke extract on NOD1 signal pathway in human oral mucosal epithelial cells. (2015)Gao YInt J Clin Exp Med