Gene info: ID 10392

Gene: NOD1

GENE ID: 10392

Synonyms: CARD4|CLR7.1|NLRC1

Description: nucleotide binding oligomerization domain containing 1

Gene type: protein-coding

Location: 7p14.3

dbXrefs: Ensembl:ENSG00000106100 MIM:605980 Vega:OTTHUMG00000023923 UniprotKB:Q9Y239

RefSeq: NG_013025.1

Retrived from: PubMed|SNP Mapped

SNPs: 1 ANCO-SNPs

Phenotype: ND|AD

# Publications: 4

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 2.639e-1 (AD) 6.984e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs2037955	chr7:30472333 (GRCh38.p7)	C>A	alcohol dependence	SNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
DAB2	0.814
APOL3	0.808
TRIM5	0.806
IL18BP	0.802
SP100	0.8
SP140L	0.799
NLRC5	0.796
TRIM22	0.794
CFLAR	0.793
STK10	0.793

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
KCNIP3	-0.378
MYADML2	-0.354
CPLX3	-0.353
WNT7A	-0.347
BCL11A	-0.341
NEUROD6	-0.341
TMEM179	-0.336
ABCC12	-0.324
RTN4R	-0.321
ASPDH	-0.316

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C524042	3,5-bis(2-fluorobenzylidene)piperidin-4-one	"3,5-bis(2-fluorobenzylidene)piperidin-4-one inhibits the reaction [Oxygen deficiency results in increased expression of NOD1 mRNA]"	23452621
C090942	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [NOD1 protein results in increased secretion of CXCL8 protein]	16365441
D000082	Acetaminophen	Acetaminophen results in increased expression of NOD1 mRNA	22230336
D020106	Acrylamide	Acrylamide results in decreased expression of NOD1 mRNA	28959563
D020106	Acrylamide	Acrylamide results in increased expression of NOD1 mRNA	28959563
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of NOD1 mRNA	24449571
D001280	Atrazine	Atrazine results in decreased expression of NOD1 mRNA	22982499
C547126	AZM551248	AZM551248 results in increased expression of NOD1 mRNA	22323515
C004456	beauvericin	beauvericin results in increased expression of NOD1 mRNA	29203277
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of NOD1 mRNA	22228805
C006780	bisphenol A	bisphenol A results in decreased expression of NOD1 mRNA	25270620
C006780	bisphenol A	bisphenol A affects the expression of NOD1 mRNA	25181051
C005961	bis(tri-n-butyltin)oxide	bis(tri-n-butyltin)oxide results in decreased expression of NOD1 mRNA	25270620
D003471	Cuprizone	Cuprizone results in decreased expression of NOD1 mRNA	26577399
D003474	Curcumin	Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of NOD1 mRNA]	23452621
C014347	decitabine	decitabine affects the expression of NOD1 mRNA	23300844
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of NOD1 mRNA	21266533
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of NOD1 mRNA	21266533
D002945	Cisplatin	Cisplatin affects the expression of NOD1 mRNA	23300844
D002945	Cisplatin	Cisplatin results in increased expression of NOD1 mRNA	21278888
D002945	Cisplatin	Cisplatin results in increased expression of NOD1 protein	21278888
D002945	Cisplatin	Cisplatin results in increased expression of NOD1 mRNA	21151649
D004052	Diethylnitrosamine	[Piperonyl Butoxide co-treated with Diethylnitrosamine] affects the methylation of NOD1 gene	23968726
D004317	Doxorubicin	Doxorubicin affects the methylation of NOD1 gene	28962528
C034330	FK 156	FK 156 binds to and results in increased activity of NOD1 protein	16299289
C039537	FK 565	FK 565 binds to and results in increased activity of NOD1 protein	16299289
D019833	Genistein	Genistein inhibits the reaction [Oxygen deficiency results in increased expression of NOD1 mRNA]	23452621
D006830	Hydralazine	[Hydralazine co-treated with Valproic Acid] results in increased expression of NOD1 mRNA	17183730
C008261	lead acetate	lead acetate results in decreased expression of NOD1 mRNA	25270620
C433788	lipopolysaccharide, E. coli O26-B6	"lipopolysaccharide, E. coli O26-B6 results in decreased expression of NOD1 mRNA"	23090859
C433788	lipopolysaccharide, E. coli O26-B6	"nickel chloride inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in decreased expression of NOD1 mRNA]"	23090859
C482199	lipopolysaccharide, E coli O55-B5	"[lipopolysaccharide, E coli O55-B5 co-treated with FSHB protein] results in decreased expression of NOD1 mRNA"	22771338
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of NOD1 mRNA	24056979
D008070	Lipopolysaccharides	methyldithiocarbamate inhibits the reaction [Lipopolysaccharides results in increased expression of NOD1 mRNA]	24056979
D008628	Mercury	Mercury results in decreased expression of NOD1 mRNA	19937285
D008727	Methotrexate	Methotrexate results in decreased expression of NOD1 mRNA	24449571
C008435	methyldithiocarbamate	methyldithiocarbamate inhibits the reaction [Lipopolysaccharides results in increased expression of NOD1 mRNA]	24056979
D009532	Nickel	Nickel results in increased expression of NOD1 mRNA	24768652\|2558310
C022838	nickel chloride	"nickel chloride inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in decreased expression of NOD1 mRNA]"	23090859
D010100	Oxygen	"3,5-bis(2-fluorobenzylidene)piperidin-4-one inhibits the reaction [Oxygen deficiency results in increased expression of NOD1 mRNA]"	23452621
D010100	Oxygen	Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of NOD1 mRNA]	23452621
D010100	Oxygen	Genistein inhibits the reaction [Oxygen deficiency results in increased expression of NOD1 mRNA]	23452621
D010100	Oxygen	Oxygen deficiency results in increased expression of NOD1 mRNA	23452621
D010100	Oxygen	Plant Extracts inhibits the reaction [Oxygen deficiency results in increased expression of NOD1 mRNA]	23452621
D010100	Oxygen	resveratrol inhibits the reaction [Oxygen deficiency results in increased expression of NOD1 mRNA]	23452621
D010882	Piperonyl Butoxide	[Piperonyl Butoxide co-treated with Diethylnitrosamine] affects the methylation of NOD1 gene	23968726
D010936	Plant Extracts	Plant Extracts inhibits the reaction [Oxygen deficiency results in increased expression of NOD1 mRNA]	23452621
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of NOD1 mRNA	24780913
C059514	resveratrol	resveratrol inhibits the reaction [Oxygen deficiency results in increased expression of NOD1 mRNA]	23452621
D013629	Tamoxifen	Tamoxifen results in increased expression of NOD1 mRNA	25123088
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of NOD1 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to NOD1 promoter]	19654925
D014241	Trichloroethylene	Trichloroethylene results in decreased expression of NOD1 mRNA	25549359
D014520	Urethane	Urethane results in increased expression of NOD1 mRNA	28818685
D014635	Valproic Acid	[Hydralazine co-treated with Valproic Acid] results in increased expression of NOD1 mRNA	17183730
D014635	Valproic Acid	Valproic Acid affects the expression of NOD1 mRNA	17292431
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of NOD1 gene	25560391

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005515	protein binding	-	IPI	10329646 15107016 15657077 16083881 17054981 17420470 19043560 19337385 20534456 23935490 25036637
GO:0005524	ATP binding	-	IEA	-
GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process	-	TAS	10329646
GO:0042802	identical protein binding	-	IDA	10329646
GO:0042802	identical protein binding	-	IPI	18186648
GO:0042803	protein homodimerization activity	-	IPI	18186648
GO:0042834	peptidoglycan binding	-	TAS	15967716
GO:0050700	CARD domain binding	-	IDA	10329646

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000187	activation of MAPK activity	-	TAS	-
GO:0002606	positive regulation of dendritic cell antigen processing and presentation	-	ISS	-
GO:0006915	apoptotic process	-	IEA	-
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	-	IDA	10329646
GO:0006952	defense response	-	TAS	15967716
GO:0006954	inflammatory response	-	TAS	15967716
GO:0007165	signal transduction	-	TAS	15967716
GO:0007254	JNK cascade	-	TAS	-
GO:0009595	detection of biotic stimulus	-	TAS	15967716
GO:0016045	detection of bacterium	-	IDA	15653568
GO:0023052	signaling	-	IBA	21873635
GO:0032731	positive regulation of interleukin-1 beta production	-	IEA	-
GO:0032755	positive regulation of interleukin-6 production	-	IEA	-
GO:0032760	positive regulation of tumor necrosis factor production	-	IEA	-
GO:0035556	intracellular signal transduction	-	IBA	21873635
GO:0035556	intracellular signal transduction	-	IDA	15653568
GO:0042228	interleukin-8 biosynthetic process	-	IDA	15653568
GO:0042742	defense response to bacterium	-	IDA	15653568
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	-	IDA	10329646
GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	-	IDA	10329646
GO:0045087	innate immune response	-	IEA	-
GO:0046330	positive regulation of JNK cascade	-	IEA	-
GO:0050830	defense response to Gram-positive bacterium	-	IEA	-
GO:0051000	positive regulation of nitric-oxide synthase activity	-	IEA	-
GO:0051092	positive regulation of NF-kappaB transcription factor activity	-	IDA	17054981 19043560
GO:0051092	positive regulation of NF-kappaB transcription factor activity	-	TAS	-
GO:0051259	protein complex oligomerization	-	TAS	15967716
GO:0070374	positive regulation of ERK1 and ERK2 cascade	-	IEA	-
GO:0070423	nucleotide-binding oligomerization domain containing signaling pathway	-	TAS	-
GO:0070498	interleukin-1-mediated signaling pathway	-	TAS	-
GO:0071225	cellular response to muramyl dipeptide	-	IMP	25093298
GO:1901224	positive regulation of NIK/NF-kappaB signaling	-	IMP	25093298
GO:1904417	positive regulation of xenophagy	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005737	cytoplasm	COLOCALIZES_WITH	IBA	21873635
GO:0005737	cytoplasm	-	IDA	10329646
GO:0005737	cytoplasm	-	TAS	15967716
GO:0005829	cytosol	-	TAS	-
GO:0016323	basolateral plasma membrane	-	IDA	19043560
GO:0016324	apical plasma membrane	-	IEA	-

KEGG ID	KEGG Term
hsa04621	NOD-like receptor signaling pathway
hsa05120	Epithelial cell signaling in Helicobacter pylori infection
hsa05131	Shigellosis

Reactome ID	Reactome Term	Evidence
R-HSA-1280215	Cytokine Signaling in Immune system	TAS
R-HSA-166016	Toll Like Receptor 4 (TLR4) Cascade	TAS
R-HSA-166058	MyD88:Mal cascade initiated on plasma membrane	TAS
R-HSA-166166	MyD88-independent TLR4 cascade	TAS
R-HSA-168138	Toll Like Receptor 9 (TLR9) Cascade	TAS
R-HSA-168142	Toll Like Receptor 10 (TLR10) Cascade	TAS
R-HSA-168164	Toll Like Receptor 3 (TLR3) Cascade	TAS
R-HSA-168176	Toll Like Receptor 5 (TLR5) Cascade	TAS
R-HSA-168179	Toll Like Receptor TLR1:TLR2 Cascade	TAS
R-HSA-168181	Toll Like Receptor 7/8 (TLR7/8) Cascade	TAS
R-HSA-168188	Toll Like Receptor TLR6:TLR2 Cascade	TAS
R-HSA-168249	Innate Immune System	TAS
R-HSA-168249	Innate Immune System	IEA
R-HSA-168256	Immune System	TAS
R-HSA-168256	Immune System	IEA
R-HSA-168638	NOD1/2 Signaling Pathway	TAS
R-HSA-168638	NOD1/2 Signaling Pathway	IEA
R-HSA-168643	Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	TAS
R-HSA-168643	Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	IEA
R-HSA-168898	Toll-Like Receptors Cascades	TAS
R-HSA-181438	Toll Like Receptor 2 (TLR2) Cascade	TAS
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-445989	TAK1 activates NFkB by phosphorylation and activation of IKKs complex	TAS
R-HSA-446652	Interleukin-1 family signaling	TAS
R-HSA-448424	Interleukin-17 signaling	TAS
R-HSA-449147	Signaling by Interleukins	TAS
R-HSA-450294	MAP kinase activation	TAS
R-HSA-450302	activated TAK1 mediates p38 MAPK activation	TAS
R-HSA-450321	JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	TAS
R-HSA-5688426	Deubiquitination	TAS
R-HSA-5689896	Ovarian tumor domain proteases	TAS
R-HSA-597592	Post-translational protein modification	TAS
R-HSA-9020702	Interleukin-1 signaling	TAS
R-HSA-937061	TRIF(TICAM1)-mediated TLR4 signaling	TAS
R-HSA-975138	TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	TAS
R-HSA-975155	MyD88 dependent cascade initiated on endosome	TAS
R-HSA-975871	MyD88 cascade initiated on plasma membrane	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
25968832	Cigarette Smoke Modulates NOD1 Signal Pathway and Human beta Defensins Expression in Human Oral Mucosa. (2015)	Qian YJ	Cell Physiol Biochem
17030188	TUCAN (CARD8) genetic variants and inflammatory bowel disease. (2006 Oct)	McGovern DP	Gastroenterology
19587002	NOD1 gene polymorphisms in relation to aggressive periodontitis. (2009 Aug)	Loos BG	Innate Immun
26550162	NOD1 agonist iE-DAP reverses effects of cigarette smoke extract on NOD1 signal pathway in human oral mucosal epithelial cells. (2015)	Gao Y	Int J Clin Exp Med