Gene: ATG7

10533
APG7-LIKE|APG7L|GSA7
autophagy related 7
protein-coding
3p25.3
Ensembl:ENSG00000197548 MIM:608760 Vega:OTTHUMG00000129740 UniprotKB:O95352
NC_000003.12
PubMed|SNP Mapped
4   ANCO-SNPs
OD|ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.170e-3 (AD)  1.503e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2606742chr3:11350243 (GRCh38.p7)G>Anicotine dependenceSNV(Single Nucleotide Variation)
rs2594978chr3:11341873 (GRCh38.p7)C>Anicotine dependenceSNV(Single Nucleotide Variation)
rs2606747chr3:11333481 (GRCh38.p7)T>C / T>Gnicotine dependenceSNV(Single Nucleotide Variation)
rs2594995chr3:11327643 (GRCh38.p7)G>Anicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
STRIP10.927
IPO90.925
RALGAPB0.925
ATRN0.924
MTOR0.924
CLTC0.922
PFKM0.92
UBE3C0.918
ATP2A20.915
MYH100.915

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.53
OR4F29-0.477
SH2D1A-0.422
HEY2-0.42
CSAG1-0.391
RAI14-0.389
TGFB3-0.388
SGMS2-0.386
CTNNA3-0.383
KLRK1-0.37

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of ATG7 mRNA"28903501
C0326681-nitropyrene1-nitropyrene results in increased expression of ATG7 mRNA29078374
C0326681-nitropyrene1-nitropyrene results in increased expression of ATG7 protein29078374
C0326681-nitropyrene3-methyladenine inhibits the reaction [1-nitropyrene results in increased expression of ATG7 mRNA]29078374
C0326681-nitropyreneCEBPA protein inhibits the reaction [1-nitropyrene results in increased expression of ATG7 protein]29078374
C0326681-nitropyreneNDUFA1 protein inhibits the reaction [1-nitropyrene results in increased expression of ATG7 mRNA]29078374
C0326681-nitropyreneNDUFA1 protein inhibits the reaction [1-nitropyrene results in increased expression of ATG7 protein]29078374
C0326681-nitropyreneNDUFA2 protein inhibits the reaction [1-nitropyrene results in increased expression of ATG7 mRNA]29078374
C0326681-nitropyreneNDUFA2 protein inhibits the reaction [1-nitropyrene results in increased expression of ATG7 protein]29078374
C0326681-nitropyrene[Taurine co-treated with 3-methyladenine] inhibits the reaction [1-nitropyrene results in increased expression of ATG7 mRNA]29078374
C0326681-nitropyrene1-nitropyrene results in increased expression of ATG7 mRNA29078374
C0326681-nitropyrene1-nitropyrene results in increased expression of ATG7 protein29078374
C0326681-nitropyreneATG7 protein affects the reaction [1-nitropyrene results in increased expression of MAP1LC3B protein]29078374
C0326681-nitropyreneATG7 protein affects the reaction [1-nitropyrene results in increased secretion of IL6 protein]29078374
C0326681-nitropyreneATG7 protein affects the susceptibility to 1-nitropyrene29078374
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of ATG7 mRNA"21346803
C00059917928-O-acetylbetulin-3-ylglucopyranosideATG7 mutant form inhibits the reaction [28-O-acetylbetulin-3-ylglucopyranoside results in increased activity of CASP3 protein]22343715
C0259463-methyladenine3-methyladenine inhibits the reaction [1-nitropyrene results in increased expression of ATG7 mRNA]29078374
C0259463-methyladenine3-methyladenine inhibits the reaction [rottlerin results in increased expression of ATG7 protein]22902833
C0259463-methyladenine[Taurine co-treated with 3-methyladenine] inhibits the reaction [1-nitropyrene results in increased expression of ATG7 mRNA]29078374
C525246(4,4-dimethyl-2,2-bipyridine)(acetylacetonate)copper(II)"(4,4-dimethyl-2,2-bipyridine)(acetylacetonate)copper(II) results in increased expression of ATG7 protein"22540380
C5550214-acetylantroquinonol B4-acetylantroquinonol B results in decreased expression of ATG7 protein28408137
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of ATG7 mRNA"21346803
C0415944-nonylphenol4-nonylphenol results in increased expression of ATG7 mRNA28041982
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of ATG7 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of ATG7 mRNA]17585979
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Apigenin results in increased expression of ATG7 protein]29247770
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ATG7 mRNA22100608
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of ATG7 mRNA"23195993
C514919alpha-solaninealpha-solanine results in increased expression of ATG7 mRNA29247839
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of ATG7 mRNA21298039
D000638AmiodaroneAmiodarone results in increased expression of ATG7 protein23912912
D000638AmiodaroneATG7 protein affects the reaction [Amiodarone results in increased cleavage of CASP3 protein]23912912
D000638AmiodaroneATG7 protein affects the susceptibility to Amiodarone23912912
D000924Anticholesteremic AgentsAnticholesteremic Agents inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of ATG7 mRNA]28275691
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of ATG7 mRNA24449571
D047310ApigeninAcetylcysteine inhibits the reaction [Apigenin results in increased expression of ATG7 protein]29247770
D047310ApigeninApigenin results in increased expression of ATG7 protein29247770
D047310ApigeninGlutathione inhibits the reaction [Apigenin results in increased expression of ATG7 protein]29247770
D001151ArsenicArsenic affects the methylation of ATG7 gene25304211
C058317arsenic disulfidearsenic disulfide results in decreased expression of ATG7 mRNA12890387
C006632arsenic trioxideATG7 protein promotes the reaction [arsenic trioxide results in increased degradation of BCR protein mutant form]22898604
C426023austenitic steel[Nickel co-treated with austenitic steel analog] results in increased expression of ATG7 mRNA23638002
C547126AZM551248AZM551248 results in decreased expression of ATG7 mRNA22323515
C057620bafilomycin AATG7 protein promotes the reaction [bafilomycin A inhibits the reaction [Nitrogen deficiency results in decreased expression of ULK1 protein]]27629431
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ATG7 mRNA20064835|2010694
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ATG7 mRNA19770486
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [ATG7 protein results in decreased expression of SQSTM1 protein]27629431
C014638beta-lapachoneATG7 protein affects the susceptibility to beta-lapachone21035436
D001688Biological ProductsBiological Products results in increased expression of ATG7 protein28219700
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of ATG7 mRNA28628672
C006780bisphenol Abisphenol A results in increased expression of ATG7 mRNA26746108
C006780bisphenol Abisphenol A results in increased methylation of ATG7 promoter27312807
C006780bisphenol Abisphenol A affects the expression of ATG7 mRNA27539358
C006780bisphenol Abisphenol A results in increased expression of ATG7 mRNA26139607
C006780bisphenol Abisphenol A results in increased methylation of ATG7 gene28505145
C000591165BO-1012ATG7 mutant form inhibits the reaction [BO-1012 results in increased phosphorylation of CHEK1 protein]24823293
C000591165BO-1012ATG7 mutant form promotes the reaction [BO-1012 results in increased cleavage of PARP1 protein]24823293
C034939cadmium sulfidecadmium sulfide results in increased expression of ATG7 mRNA27866839
D002110CaffeineATG7 protein results in increased susceptibility to Caffeine21081844
D002110CaffeineATG7 results in increased susceptibility to Caffeine21081844
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of ATG7 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of ATG7 mRNA]17585979
C017160cypermethrincypermethrin results in increased expression of ATG7 mRNA27704156
D003609DactinomycinDactinomycin inhibits the reaction [Ethanol results in increased expression of ATG7 protein]24095927
D003847DeoxyglucoseATG7 protein inhibits the reaction [Deoxyglucose results in increased cleavage of CASP3 protein]20593179
D003847DeoxyglucoseATG7 protein inhibits the reaction [Deoxyglucose results in increased expression of DDIT3 protein]20593179
D003847DeoxyglucoseATG7 protein inhibits the reaction [Deoxyglucose results in increased expression of HSPA5 protein]20593179
D003847DeoxyglucoseATG7 protein promotes the reaction [Deoxyglucose results in increased prenylation of MAP1LC3B protein]20593179
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of ATG7 mRNA]27941970
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of ATG7 mRNA28628672
D002945CisplatinCisplatin results in decreased expression of ATG7 mRNA19561079
D002945CisplatinCisplatin results in decreased expression of ATG7 protein28408137
D004026DieldrinDieldrin results in increased expression of ATG7 mRNA28385952
D004041Dietary FatsAnticholesteremic Agents inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of ATG7 mRNA]28275691
D004041Dietary Fats[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of ATG7 mRNA28275691
D019422Dietary SucroseAnticholesteremic Agents inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of ATG7 mRNA]28275691
D019422Dietary Sucrose[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of ATG7 mRNA28275691
D004051Diethylhexyl PhthalateATG7 protein inhibits the reaction [Diethylhexyl Phthalate results in increased expression of ACAA1A protein]16332691
D004317DoxorubicinATG7 mutant form inhibits the reaction [Doxorubicin results in increased degradation of SQSTM1 protein]22927544
D000069347Erlotinib HydrochlorideErlotinib Hydrochloride results in increased expression of ATG7 protein21655094
D000431EthanolEthanol results in increased expression of ATG7 mRNA24095927
D000431EthanolATG7 mutant form inhibits the reaction [Ethanol results in increased lipidation of MAP1LC3B protein]24492484
D000431EthanolDactinomycin inhibits the reaction [Ethanol results in increased expression of ATG7 protein]24095927
D000431EthanolEthanol results in increased expression of ATG7 mRNA24095927|2449248
D000431EthanolEthanol results in increased expression of ATG7 protein24095927|2449248
D000431EthanolFOXO3 protein affects the reaction [Ethanol results in increased expression of ATG7 mRNA]24095927
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of ATG7 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of ATG7 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ATG7 mRNA17942748
D011345FenofibrateFenofibrate results in increased expression of ATG7 mRNA21318169
D011345FenofibratePPARA protein affects the reaction [Fenofibrate results in increased expression of ATG7 mRNA]21318169
D000068876Fingolimod HydrochlorideFingolimod Hydrochloride results in increased expression of ATG7 protein25939952
C419708gefitinibgefitinib results in increased expression of ATG7 protein21655094
D005978GlutathioneGlutathione inhibits the reaction [Apigenin results in increased expression of ATG7 protein]29247770
D017313FenretinideFenretinide results in decreased expression of ATG7 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of ATG7 protein23726866
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of ATG7 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ATG7 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of ATG7 mRNA28628672
D008070Lipopolysaccharides[Tetrachlorodibenzodioxin co-treated with Lipopolysaccharides] results in decreased methylation of ATG7 gene21212295
C005219methyl cellosolvemethyl cellosolve results in increased expression of ATG7 mRNA21061450
C523184mocetinostatmocetinostat results in decreased expression of ATG7 mRNA27255383
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of ATG7 mRNA"29244179
D009532Nickel[Nickel co-treated with austenitic steel analog] results in increased expression of ATG7 mRNA23638002
D009532NickelNickel results in decreased expression of ATG7 mRNA23195993
C028007nickel monoxidenickel monoxide results in increased expression of ATG7 mRNA19167457
D009584NitrogenATG7 protein inhibits the reaction [Nitrogen deficiency results in decreased expression of ULK1 protein]27629431
D009584NitrogenATG7 protein promotes the reaction [bafilomycin A inhibits the reaction [Nitrogen deficiency results in decreased expression of ULK1 protein]]27629431
C010615Nonidet P-40Nonidet P-40 results in decreased expression of ATG7 mRNA26552463
D009842OligopeptidesOligopeptides analog results in increased expression of ATG7 protein24875536
D010126OzoneOzone results in increased expression of ATG7 mRNA27206323
D010269ParaquatParaquat results in increased expression of ATG7 mRNA27220436
D010269ParaquatParaquat results in increased expression of ATG7 protein27246695
D010269ParaquatTLR4 protein affects the reaction [Paraquat results in increased expression of ATG7 protein]27246695
D010433PentylenetetrazolePentylenetetrazole affects the expression of ATG7 mRNA21503142
D010634PhenobarbitalPhenobarbital affects the expression of ATG7 mRNA23091169
D010795Phthalic AcidsPhthalic Acids results in increased expression of ATG7 mRNA21061450
C006253pirinixic acidpirinixic acid results in increased expression of ATG7 mRNA21318169
C006253pirinixic acidPPARA protein affects the reaction [pirinixic acid results in increased expression of ATG7 mRNA]21318169
C060540polyhexamethyleneguanidinepolyhexamethyleneguanidine results in increased expression of ATG7 mRNA24583197
D011794QuercetinQuercetin results in increased expression of ATG7 protein25293876
C012526quercitrinquercitrin results in decreased expression of ATG7 mRNA25193878
D012402RotenoneRotenone results in increased expression of ATG7 protein25682864
C085746rottlerin3-methyladenine inhibits the reaction [rottlerin results in increased expression of ATG7 protein]22902833
C085746rottlerinrottlerin results in increased expression of ATG7 protein22902833
C017947sodium arseniteATG7 mutant form inhibits the reaction [sodium arsenite results in decreased expression of SNCA]25639566
D012969Sodium FluorideSodium Fluoride results in increased expression of ATG7 mRNA24296261
D012969Sodium FluorideSodium Fluoride results in increased expression of ATG7 protein24296261
D012969Sodium FluorideSodium Fluoride results in increased expression of ATG7 mRNA24296261
D019311StaurosporineATG7 protein affects the susceptibility to Staurosporine16497721
D013629TamoxifenTamoxifen affects the expression of ATG7 mRNA17555576
D013654Taurine[Taurine co-treated with 3-methyladenine] inhibits the reaction [1-nitropyrene results in increased expression of ATG7 mRNA]29078374
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ATG7 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ATG7 mRNA17942748
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Lipopolysaccharides] results in decreased methylation of ATG7 gene21212295
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased methylation of ATG7 gene21212295
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ATG7 mRNA25613284
C009438tetrandrinetetrandrine results in decreased expression of ATG7 protein25266202
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of ATG7 mRNA19042947
C001899triptolidetriptolide results in increased expression of ATG7 protein26990902
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of ATG7 gene25560391
C025643vinclozolinvinclozolin results in decreased expression of ATG7 mRNA23034163
C111237vorinostatATG7 affects the susceptibility to vorinostat21148553
C111237vorinostatATG7 protein promotes the reaction [vorinostat results in increased cleavage of MAP1LC3B protein]17881280
C111237vorinostatvorinostat results in increased expression of ATG7 protein20543569

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004839ubiquitin activating enzyme activity-TAS10233149  
GO:0005515protein binding-IPI11096062  11825910  16303767  18083104  18296641  20195357  
20562859  21903422  
GO:0008134transcription factor binding-IPI20543840  
GO:0019778Atg12 activating enzyme activity-IBA21873635  
GO:0019778Atg12 activating enzyme activity-ISS20723759  
GO:0019779Atg8 activating enzyme activity-IBA21873635  
GO:0042803protein homodimerization activity-IDA11096062  
GO ID GO Term Qualifier Evidence PubMed
GO:0000045autophagosome assembly-IBA21873635  
GO:0000422autophagy of mitochondrion-IBA21873635  
GO:0000422autophagy of mitochondrion-IGI19279012  
GO:0006464cellular protein modification process-TAS10233149  
GO:0006497protein lipidation-IDA12890687  
GO:0006501C-terminal protein lipidation-IBA21873635  
GO:0006914autophagy-IMP20543840  24681637  25327288  
GO:0006995cellular response to nitrogen starvation-IBA21873635  
GO:0007568aging-IEA-  
GO:0009267cellular response to starvation-IDA20543840  
GO:0009749response to glucose-IEA-  
GO:0010508positive regulation of autophagy-IEA-  
GO:0015031protein transport-IEA-  
GO:0016236macroautophagy-IMP22354037  
GO:0016236macroautophagy-TAS-  
GO:0016567protein ubiquitination-IEA-  
GO:0031401positive regulation of protein modification process-IDA12890687  
GO:0034727piecemeal microautophagy of the nucleus-IBA21873635  
GO:0039521suppression by virus of host autophagy-IMP23290079  
GO:0043065positive regulation of apoptotic process-IMP20543840  
GO:0043312neutrophil degranulation-TAS-  
GO:0044805late nucleophagy-IBA21873635  
GO:0045732positive regulation of protein catabolic process-IMP20543840  
GO:0051607defense response to virus-IMP23290079  
GO:0061025membrane fusion-TAS10233149  
GO:0071315cellular response to morphine-IEA-  
GO:0071455cellular response to hyperoxia-IDA20543840  
GO:0075044autophagy of host cells involved in interaction with symbiont-IGI28389568  
GO:0090298negative regulation of mitochondrial DNA replication-IEA-  
GO:1902617response to fluoride-IEA-  
GO:1903204negative regulation of oxidative stress-induced neuron death-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000407phagophore assembly site-IBA21873635  
GO:0005576extracellular region-TAS-  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IDA20543840  
GO:0005829cytosol-TAS-  
GO:0005930axoneme-ISS-  
GO:0030424axon-IEA-  
GO:0034774secretory granule lumen-TAS-  
GO:1904813ficolin-1-rich granule lumen-TAS-  
KEGG ID KEGG Term
hsa04140Regulation of autophagy
Reactome ID Reactome Term Evidence
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-1632852MacroautophagyTAS
R-HSA-1632852MacroautophagyIEA
R-HSA-1643685DiseaseTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-5663202Diseases of signal transductionTAS
R-HSA-6798695Neutrophil degranulationTAS
R-HSA-6802952Signaling by BRAF and RAF fusionsTAS
R-HSA-6802957Oncogenic MAPK signalingTAS
R-HSA-8953897Cellular responses to external stimuliTAS
R-HSA-8953897Cellular responses to external stimuliIEA
R-HSA-983168Antigen processing: Ubiquitination & Proteasome degradationTAS
R-HSA-983169Class I MHC mediated antigen processing & presentationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23800874Decreased mitochondrial DNA copy number in the hippocampus and peripheral blood during opiate addiction is mediated by autophagy and can be salvaged by melatonin. (2013 Sep)Feng YMAutophagy
24874076A novel protective mechanism for mitochondrial aldehyde dehydrogenase (ALDH2) in type i diabetes-induced cardiac dysfunction: role of AMPK-regulated autophagy. (2015 Feb)Guo YBiochim Biophys Acta