Gene: ARL6IP5

10550
DERP11|GTRAP3-18|HSPC127|JWA|PRAF3|Yip6b|addicsin|hp22|jmx
ADP ribosylation factor like GTPase 6 interacting protein 5
protein-coding
3p14.1
Ensembl:ENSG00000144746 MIM:605709 Vega:OTTHUMG00000158773 UniprotKB:O75915
NC_000003.12
PubMed|SNP Mapped
1   ANCO-SNPs
AD
1   
NA (AD)  1.365e-1 (ND)   (Frontal_Cortex)
9.470e-1 (AD)  4.619e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs6549184chr3:69101126 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
VAPA0.964
EIF4A20.963
DNAJA20.961
PPP2CA0.96
MORF4L20.96
RAD23B0.959
EIF1B0.959
RAB140.958
YPEL50.957
ARL8B0.957

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.744
OR4F29-0.7
MTRNR2L6-0.282
KLRB1-0.279
MTRNR2L10-0.277
FZD10-0.271
CSAG1-0.268
MTRNR2L9-0.266
VNN3-0.263
MMP9-0.261

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of ARL6IP5 mRNA19933214
D000082AcetaminophenAcetaminophen results in decreased expression of ARL6IP5 mRNA21420995|2906747
D000082AcetaminophenAcetaminophen affects the expression of ARL6IP5 mRNA17562736
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ARL6IP5 mRNA16483693
C006632arsenic trioxideARL6IP5 protein promotes the reaction [arsenic trioxide results in increased cleavage of CASP9 protein]18387645
C006632arsenic trioxideARL6IP5 protein promotes the reaction [arsenic trioxide results in increased phosphorylation of and results in increased activity of MAPK1 protein]18387645
C006632arsenic trioxideARL6IP5 protein promotes the reaction [arsenic trioxide results in increased phosphorylation of and results in increased activity of MAPK3 protein]18387645
C006632arsenic trioxideARL6IP5 protein results in increased susceptibility to arsenic trioxide18387645
C006632arsenic trioxide[arsenic trioxide results in increased abundance of Hydrogen Peroxide] which results in increased expression of ARL6IP5 protein18387645
C006632arsenic trioxidearsenic trioxide results in increased expression of ARL6IP5 protein16430862
C006632arsenic trioxideCAT protein inhibits the reaction [[arsenic trioxide results in increased abundance of Hydrogen Peroxide] which results in increased expression of ARL6IP5 protein]18387645
C006632arsenic trioxide[Tretinoin co-treated with arsenic trioxide] results in increased expression of ARL6IP5 mRNA16468075
C006632arsenic trioxideARL6IP5 protein results in increased susceptibility to arsenic trioxide21847655
C015001arsenite[arsenite co-treated with Benzo(a)pyrene] results in increased expression of ARL6IP5 mRNA15894712
C015001arsenitearsenite results in increased expression of ARL6IP5 mRNA15894712
D001241AspirinAspirin results in increased expression of ARL6IP5 mRNA15928584
D001280AtrazineAtrazine results in decreased expression of ARL6IP5 mRNA25929836
C547126AZM551248AZM551248 results in increased expression of ARL6IP5 mRNA22323515
D001564Benzo(a)pyrene[arsenite co-treated with Benzo(a)pyrene] results in increased expression of ARL6IP5 mRNA15894712
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ARL6IP5 mRNA15034205|1589471
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [ARL6IP5 mutant form inhibits the reaction [Morphine results in increased expression of OPRD1 protein]]21600884
D004958EstradiolEstradiol affects the expression of ARL6IP5 mRNA14699072
D004958EstradiolEstradiol results in decreased expression of ARL6IP5 mRNA23019147
C044887beta-methylcholinebeta-methylcholine affects the expression of ARL6IP5 mRNA21179406
C095105bexarotenebexarotene results in increased expression of ARL6IP5 mRNA17178900
C006780bisphenol Abisphenol A affects the expression of ARL6IP5 mRNA25181051
C013418bromfenacoumbromfenacoum results in increased expression of ARL6IP5 protein28903499
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of ARL6IP5 mRNA15336504
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of ARL6IP5 mRNA27339419
C099555CD 437CD 437 affects the expression of ARL6IP516720286
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of ARL6IP5 mRNA25270620
C100187chloropicrinchloropicrin results in increased expression of ARL6IP5 mRNA26352163
D002994ClofibrateClofibrate results in decreased expression of ARL6IP5 mRNA17585979
D019327Copper SulfateCopper Sulfate results in decreased expression of ARL6IP5 mRNA19549813
D003471CuprizoneCuprizone results in decreased expression of ARL6IP5 mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of ARL6IP5 mRNA20106945|2556210
D003561CytarabineCytarabine results in increased expression of ARL6IP5 protein16430862
C014347decitabinedecitabine affects the expression of ARL6IP5 mRNA23300844
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of ARL6IP5 mRNA21266533
D002945CisplatinARL6IP5 protein affects the susceptibility to [Fluorouracil co-treated with Leucovorin co-treated with Cisplatin]22452940
D002945CisplatinCisplatin affects the expression of ARL6IP5 mRNA23300844
C000944dicrotophosdicrotophos results in decreased expression of ARL6IP5 mRNA28302478
D004317DoxorubicinDoxorubicin results in increased expression of ARL6IP5 protein16430862
C070609EMD 53998EMD 53998 analog results in decreased expression of ARL6IP5 mRNA24977338
D005047EtoposideARL6IP5 protein results in increased susceptibility to Etoposide19492242
D005047EtoposideEtoposide results in decreased expression of ARL6IP519492242
D005472FluorouracilARL6IP5 protein affects the susceptibility to [Fluorouracil co-treated with Leucovorin co-treated with Cisplatin]22452940
D005472FluorouracilARL6IP5 protein affects the susceptibility to [Fluorouracil co-treated with Leucovorin co-treated with oxaliplatin]22452940
D005485FlutamideFlutamide results in increased expression of ARL6IP5 mRNA24136188
D002955LeucovorinARL6IP5 protein affects the susceptibility to [Fluorouracil co-treated with Leucovorin co-treated with Cisplatin]22452940
D002955LeucovorinARL6IP5 protein affects the susceptibility to [Fluorouracil co-treated with Leucovorin co-treated with oxaliplatin]22452940
C040029gabapentin[gabapentin co-treated with Pentylenetetrazole] affects the expression of ARL6IP5 mRNA21503142
D005839GentamicinsGentamicins results in increased expression of ARL6IP5 mRNA22061828
D006427HeminHemin results in increased expression of ARL6IP5 protein16430862
D017313FenretinideFenretinide affects the expression of ARL6IP516720286
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of ARL6IP5 mRNA17183730
D006861Hydrogen Peroxide[arsenic trioxide results in increased abundance of Hydrogen Peroxide] which results in increased expression of ARL6IP5 protein18387645
D006861Hydrogen PeroxideCAT protein inhibits the reaction [[arsenic trioxide results in increased abundance of Hydrogen Peroxide] which results in increased expression of ARL6IP5 protein]18387645
C013038hydroxyhydroquinonehydroxyhydroquinone results in decreased expression of ARL6IP5 mRNA17572062
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of ARL6IP5 mRNA25613284
C011890kojic acidkojic acid results in increased expression of ARL6IP5 mRNA16595896
D008748MethylcholanthreneMethylcholanthrene results in increased expression of ARL6IP5 mRNA20713471
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of ARL6IP5 mRNA23179753
C043243methyl tert-butyl ethermethyl tert-butyl ether affects the expression of ARL6IP5 mRNA24128854
D009020MorphineARL6IP5 mutant form inhibits the reaction [Morphine results in increased expression of OPRD1 protein]21600884
D009020MorphineARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK1 protein]21600884
D009020MorphineARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK3 protein]21600884
D009020MorphineARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of PPP1R1B protein]21600884
D009020MorphineMorphine promotes the reaction [ARL6IP5 protein binds to OPRD1 protein]21600884
D009020MorphineARL6IP5 mutant form inhibits the reaction [Morphine results in increased expression of OPRD1 protein]21600884
D009020MorphineARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK1 protein]21600884
D009020MorphineARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK3 protein]21600884
D009020MorphineARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of PPP1R1B protein]21600884
D009020Morphinebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [ARL6IP5 mutant form inhibits the reaction [Morphine results in increased expression of OPRD1 protein]]21600884
D009020MorphineMorphine promotes the reaction [ARL6IP5 protein binds to OPRD1 protein]21600884
D009020MorphineMorphine results in increased expression of ARL6IP5 protein21600884
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of ARL6IP5 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of ARL6IP5 mRNA"25554681|2562005
C017557nickel subsulfidenickel subsulfide results in increased expression of ARL6IP5 mRNA21086188
C030110oxaliplatinARL6IP5 protein affects the susceptibility to [Fluorouracil co-treated with Leucovorin co-treated with oxaliplatin]22452940
D010269ParaquatARL6IP5 protein affects the reaction [Paraquat affects the expression of NFE2L2 protein]28428137
D010269ParaquatARL6IP5 protein affects the reaction [Paraquat affects the phosphorylation of AKT1 protein]28428137
D010269ParaquatARL6IP5 protein affects the reaction [Paraquat affects the phosphorylation of MAPK1 protein]28428137
D010269ParaquatARL6IP5 protein affects the reaction [Paraquat affects the phosphorylation of MAPK3 protein]28428137
D010269ParaquatParaquat results in increased expression of ARL6IP5 protein28428137
D010269ParaquatARL6IP5 protein affects the reaction [Paraquat affects the expression of NFE2L2 protein]28428137
D010269ParaquatARL6IP5 protein affects the reaction [Paraquat affects the expression of TH protein]28428137
D010269ParaquatARL6IP5 protein affects the reaction [Paraquat affects the phosphorylation of AKT1 protein]28428137
D010269ParaquatARL6IP5 protein affects the reaction [Paraquat affects the phosphorylation of MAPK1 protein]28428137
D010269ParaquatARL6IP5 protein affects the reaction [Paraquat affects the phosphorylation of MAPK3 protein]28428137
D010269ParaquatARL6IP5 protein affects the susceptibility to Paraquat28428137
D010269ParaquatParaquat results in increased expression of ARL6IP528428137
D010433Pentylenetetrazole[gabapentin co-treated with Pentylenetetrazole] affects the expression of ARL6IP5 mRNA21503142
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of ARL6IP5 protein26879310
D010634PhenobarbitalPhenobarbital results in increased expression of ARL6IP5 mRNA19270015
C003135phoximphoxim affects the expression of ARL6IP5 protein15799245
D010894PiroxicamPiroxicam results in increased expression of ARL6IP5 mRNA21858171
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of ARL6IP5 mRNA22714537
D011374ProgesteroneProgesterone results in decreased expression of ARL6IP5 mRNA19690047
D011441PropylthiouracilPropylthiouracil results in decreased expression of ARL6IP5 mRNA24780913
D011794QuercetinQuercetin results in decreased expression of ARL6IP5 mRNA21632981
D012402RotenoneRotenone results in decreased expression of ARL6IP5 mRNA23186747
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ARL6IP5 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of ARL6IP5 mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ARL6IP5 mRNA15034205|1566782
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate inhibits the reaction [Tretinoin results in increased expression of ARL6IP5 mRNA]16468075
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of ARL6IP5 protein16430862
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of ARL6IP5 mRNA25613284
D014212TretinoinARL6IP5 protein affects the reaction [Tretinoin results in increased phosphorylation of MAPK1 protein]16922813
D014212TretinoinARL6IP5 protein affects the reaction [Tretinoin results in increased phosphorylation of MAPK3 protein]16922813
D014212TretinoinARL6IP5 protein results in increased susceptibility to Tretinoin16922813
D014212TretinoinTetradecanoylphorbol Acetate inhibits the reaction [Tretinoin results in increased expression of ARL6IP5 mRNA]16468075
D014212TretinoinTretinoin affects the expression of ARL6IP516720286
D014212Tretinoin[Tretinoin co-treated with arsenic trioxide] results in increased expression of ARL6IP5 mRNA16468075
D014212TretinoinTretinoin results in increased expression of ARL6IP5 mRNA16468075|1692281
D014212TretinoinTretinoin results in increased expression of ARL6IP5 protein16430862|1692281
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of ARL6IP5 mRNA17183730
D014635Valproic AcidValproic Acid affects the expression of ARL6IP5 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of ARL6IP5 mRNA19101580|2317975
D015032ZincZinc deficiency results in decreased expression of ARL6IP5 mRNA22171008

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003674molecular_function-ND-  
GO:0005515protein binding-IPI25416956  
GO ID GO Term Qualifier Evidence PubMed
GO:0002037negative regulation of L-glutamate import across plasma membrane-ISS-  
GO:0008631intrinsic apoptotic signaling pathway in response to oxidative stress-IDA18387645  
GO:0010917negative regulation of mitochondrial membrane potential-IMP18387645  
GO:0015813L-glutamate transmembrane transport-ISS-  
GO:0032874positive regulation of stress-activated MAPK cascade-IMP18387645  
GO:0043065positive regulation of apoptotic process-IMP18387645  
GO:0043280positive regulation of cysteine-type endopeptidase activity involved in apoptotic process-IMP18387645  
GO ID GO Term Qualifier Evidence PubMed
GO:0005789endoplasmic reticulum membrane-IEA-  
GO:0005856cytoskeleton-IEA-  
GO:0005886plasma membrane-IEA-  
GO:0016020membrane-HDA19946888  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-112310Neurotransmitter release cycleTAS
R-HSA-112315Transmission across Chemical SynapsesTAS
R-HSA-112316Neuronal SystemTAS
R-HSA-210500Glutamate Neurotransmitter Release CycleTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11. (2010 May)Edenberg HJAlcohol Clin Exp Res