Gene: AHSA1

10598
AHA1|C14orf3|hAha1|p38
activator of HSP90 ATPase activity 1
protein-coding
14q24.3
Ensembl:ENSG00000100591 MIM:608466 Vega:OTTHUMG00000171539 UniprotKB:O95433
NC_000014.9
SNP Mapped
1   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.909e-1 (AD)  6.424e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs3825694chr14:77468244 (GRCh38.p7)T>Cnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
STIP10.958
CCT30.955
NUDT90.949
DNAJB60.947
CACYBP0.941
DEDD20.935
DNAJA10.927
CCT40.926
PPID0.922
FKBP40.92

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.643
OR4F29-0.61
KLRF1-0.41
KLRB1-0.4
IL18RAP-0.366
IL2RB-0.356
CNGA1-0.345
TIGIT-0.343
CC2D2B-0.342
FOXL1-0.338

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of AHSA1 mRNA"18648102
C517041(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in increased expression of AHSA1 mRNA"19561079
C0757734-phenylbutyric acid4-phenylbutyric acid results in increased expression of AHSA1 mRNA14583596
C4771875-(4-methylpiperazin-1-yl)-2-(2'-(3,4-dimethoxyphenyl)-5'-benzimidazolyl)benzimidazole"5-(4-methylpiperazin-1-yl)-2-(2'-(3,4-dimethoxyphenyl)-5'-benzimidazolyl)benzimidazole affects the expression of AHSA1 mRNA"22745752
D000082AcetaminophenAHSA1 gene polymorphism affects the susceptibility to Acetaminophen26104854
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of AHSA1 gene27153756
D001280AtrazineAtrazine results in decreased expression of AHSA1 mRNA22982499
D001507BeclomethasoneBeclomethasone results in increased expression of AHSA1 mRNA23656298
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of AHSA1 mRNA22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of AHSA1 mRNA22300585
C006780bisphenol Abisphenol A results in increased expression of AHSA1 mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of AHSA1 mRNA15336504
D019256Cadmium ChlorideCadmium Chloride results in increased expression of AHSA1 protein24527689
C100187chloropicrinchloropicrin results in increased expression of AHSA1 mRNA26352163
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of AHSA1 gene20938992
D003300Copper[Disulfiram binds to Copper] which results in decreased expression of AHSA1 mRNA24690739
D019327Copper SulfateCopper Sulfate affects the expression of AHSA1 mRNA19549813
D003375CoumestrolCoumestrol results in increased expression of AHSA1 mRNA19167446
C030973cupric oxidecupric oxide results in increased phosphorylation of AHSA1 protein25470785
D016572CyclosporineCyclosporine results in increased expression of AHSA1 mRNA20106945|2556210
D003907DexamethasoneDexamethasone results in increased expression of AHSA1 mRNA17998272
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of AHSA1 mRNA28085963
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of AHSA1 mRNA17942915
D004052DiethylnitrosamineMET protein inhibits the reaction [Diethylnitrosamine results in increased expression of AHSA1 mRNA]17942915
D004221Disulfiram[Disulfiram binds to Copper] which results in decreased expression of AHSA1 mRNA24690739
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of AHSA1 mRNA17555576|1794274
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of AHSA1 mRNA17942748
D015025Zearalenone[Zearalenone co-treated with CGA protein] results in increased expression of AHSA1 protein25058043
D018120FinasterideFinasteride results in increased expression of AHSA1 mRNA24136188
D005485FlutamideFlutamide results in increased expression of AHSA1 mRNA24136188
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of AHSA1 gene20938992
C106014geduningedunin results in increased expression of AHSA1 mRNA17010675
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of AHSA1 mRNA20044591
C492448ICG 001ICG 001 results in increased expression of AHSA1 mRNA26191083
D019290Megestrol AcetateMegestrol Acetate results in increased expression of AHSA1 protein16939895
D008627Mercuric ChlorideMercuric Chloride affects the expression of AHSA1 mRNA20353558
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of AHSA1 gene20938992
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of AHSA1 mRNA"20188158
C063855microcystin RRmicrocystin RR results in increased expression of AHSA1 protein19111056
C051752nefazodonenefazodone results in increased expression of AHSA1 mRNA24136188
C012655nimesulidenimesulide results in increased expression of AHSA1 mRNA24136188
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of AHSA1 mRNA18593933
D010416PentachlorophenolPentachlorophenol results in increased expression of AHSA1 mRNA23892564
C006253pirinixic acidpirinixic acid results in increased expression of AHSA1 mRNA18301758|2131816
C006253pirinixic acidPPARA protein affects the reaction [pirinixic acid results in increased expression of AHSA1 mRNA]21318169
C031280pyrazolepyrazole results in increased expression of AHSA1 mRNA17945193
D012834SilverSilver results in increased expression of AHSA1 mRNA26014281
D013629TamoxifenTamoxifen affects the expression of AHSA1 mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of AHSA1 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of AHSA1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of AHSA1 mRNA17942748
C009495titanium dioxidetitanium dioxide results in increased expression of AHSA1 mRNA23409001
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of AHSA1 mRNA22363418|2806579
C050414tripterinetripterine results in increased expression of AHSA1 mRNA17010675
D014415TunicamycinTunicamycin results in decreased expression of AHSA1 mRNA17127020
D014520UrethaneUrethane results in increased expression of AHSA1 mRNA28818685
C406224valdecoxibvaldecoxib results in increased expression of AHSA1 mRNA24136188
D014635Valproic AcidValproic Acid affects the expression of AHSA1 mRNA17292431
D014810Vitamin EVitamin E results in increased expression of AHSA1 mRNA19244175
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of AHSA1 mRNA18593933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001671ATPase activator activity-IDA12504007  27353360  29127155  
GO:0005515protein binding-IPI12604615  16696853  19875381  20618441  25036637  25486457  
27353360  
GO:0045296cadherin binding-HDA25468996  
GO:0051087chaperone binding-IDA12504007  27353360  
GO:0051879Hsp90 protein binding-IPI29127155  
GO ID GO Term Qualifier Evidence PubMed
GO:0006950response to stress-IEA-  
GO:0032781positive regulation of ATPase activity-IDA29127155  
GO ID GO Term Qualifier Evidence PubMed
GO:0005783endoplasmic reticulum-IEA-  
GO:0005829cytosol-IDA-  
GO:0070062extracellular exosome-HDA19056867  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal