Gene info: ID 10690

Gene: FUT9

GENE ID: 10690

Synonyms: Fuc-TIX

Description: fucosyltransferase 9

Gene type: protein-coding

Location: 6q16.1

dbXrefs: Ensembl:ENSG00000172461 MIM:606865 Vega:OTTHUMG00000015236 UniprotKB:Q9Y231

RefSeq: NC_000006.12

Retrived from: SNP Mapped

SNPs: 1 ANCO-SNPs

Phenotype: AD

# Publications: 0

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 4.629e-2 (AD) 1.327e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs4132260	chr6:96147144 (GRCh38.p7)	C>T	alcohol dependence	SNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
LSAMP	0.857
PCDH10	0.844
ACSL6	0.839
CNTN1	0.836
MEGF9	0.834
CADM2	0.83
B3GALT1	0.827
ASTN1	0.826
NRXN1	0.825
ANK2	0.823

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
TFPI2	-0.64
C9orf135	-0.549
FCRLA	-0.529
BEST3	-0.512
PRRX2	-0.506
FOXI2	-0.501
C2orf83	-0.499
KIAA0040	-0.498
FCER2	-0.495
LILRB2	-0.494

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FUT9 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FUT9 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FUT9 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FUT9 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FUT9 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FUT9 mRNA"	27188386
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of FUT9 gene	27153756
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of FUT9 mRNA	16483693
C059765	amphotericin B, deoxycholate drug combination	"amphotericin B, deoxycholate drug combination results in decreased expression of FUT9 mRNA"	22863853
C487081	belinostat	belinostat results in increased expression of FUT9 mRNA	27188386
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of FUT9 mRNA	22300585
D004958	Estradiol	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of FUT9 mRNA	19619570
D004958	Estradiol	Estradiol results in decreased expression of FUT9 mRNA	21185374
D004958	Estradiol	Estradiol results in increased expression of FUT9 mRNA	19619570
C006780	bisphenol A	bisphenol A affects the expression of FUT9 mRNA	21786754
C006780	bisphenol A	[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of FUT9 promoter	23359474
C006780	bisphenol A	bisphenol A results in decreased expression of FUT9 mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased expression of FUT9 mRNA	29097150
D003993	Dibutyl Phthalate	[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of FUT9 promoter	23359474
D004051	Diethylhexyl Phthalate	[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of FUT9 promoter	23359474
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of FUT9 mRNA	29097150
D007854	Lead	Lead affects the expression of FUT9 mRNA	28903495
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of FUT9 mRNA	28001369
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of FUT9 mRNA"	20188158
C583365	N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide	"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of FUT9 mRNA"	29244179
C496932	panobinostat	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FUT9 mRNA"	27188386
C496932	panobinostat	panobinostat results in decreased expression of FUT9 mRNA	26272509
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FUT9 mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in decreased expression of FUT9 mRNA	26272509
C006253	pirinixic acid	pirinixic acid results in increased expression of FUT9 mRNA	20813756
D020849	Raloxifene Hydrochloride	[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of FUT9 mRNA	19059307
C513635	S-2-pentyl-4-pentynoic hydroxamic acid	S-2-pentyl-4-pentynoic hydroxamic acid results in decreased expression of FUT9 mRNA	21427059
D013629	Tamoxifen	[Tamoxifen co-treated with ESR2 protein] results in increased expression of FUT9 mRNA	19059307
D013749	Tetrachlorodibenzodioxin	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of FUT9 mRNA	19619570
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of FUT9 mRNA	19619570
D014212	Tretinoin	Tretinoin results in decreased expression of FUT9 mRNA	21934132
C012589	trichostatin A	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FUT9 mRNA"	27188386
C012589	trichostatin A	trichostatin A results in decreased expression of FUT9 mRNA	24935251\|2627250
C012589	trichostatin A	trichostatin A results in increased expression of FUT9 mRNA	24935251
D014635	Valproic Acid	Valproic Acid results in decreased expression of FUT9 mRNA	23179753\|2800136
D014635	Valproic Acid	Valproic Acid results in increased expression of FUT9 mRNA	24935251
D014635	Valproic Acid	Valproic Acid results in decreased expression of FUT9 mRNA	21427059
D014640	Vancomycin	Vancomycin results in increased expression of FUT9 mRNA	18930951
D001335	Vehicle Emissions	Vehicle Emissions results in increased methylation of FUT9 gene	25560391
C025643	vinclozolin	vinclozolin results in increased expression of FUT9 mRNA	21126777
C029297	vinylidene chloride	vinylidene chloride results in decreased expression of FUT9 mRNA	26682919
D015032	Zinc	Zinc deficiency results in decreased expression of FUT9 mRNA	18356318

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0008417	fucosyltransferase activity	-	TAS	10386598
GO:0046920	alpha-(1->3)-fucosyltransferase activity	-	IBA	21873635
GO:0046920	alpha-(1->3)-fucosyltransferase activity	-	TAS	11698403

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005975	carbohydrate metabolic process	-	TAS	10386598
GO:0006486	protein glycosylation	-	IEA	-
GO:0006486	protein glycosylation	-	TAS	11698403
GO:0007399	nervous system development	-	IEA	-
GO:0036065	fucosylation	-	IBA	21873635
GO:0036065	fucosylation	-	IEA	-
GO:0042355	L-fucose catabolic process	-	NAS	11698403

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005794	Golgi apparatus	-	TAS	11698403
GO:0016021	integral component of membrane	-	IEA	-
GO:0032580	Golgi cisterna membrane	-	IEA	-

KEGG ID	KEGG Term
hsa00514	Other types of O-glycan biosynthesis
hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series
hsa00603	Glycosphingolipid biosynthesis - globo series
hsa01100	Metabolic pathways

Reactome ID	Reactome Term	Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal