Gene: POP1

10940
ANXD2
POP1 homolog, ribonuclease P/MRP subunit
protein-coding
8q22.2
Ensembl:ENSG00000104356 MIM:602486 Vega:OTTHUMG00000164635 UniprotKB:Q99575
NG_052869.1
SNP Mapped
4   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.862e-1 (AD)  4.865e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs4735529chr8:98127382 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs10808358chr8:98124925 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs4734384chr8:98121450 (GRCh38.p7)A>Calcohol dependenceSNV(Single Nucleotide Variation)
rs2071597chr8:98117421 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
POLR1A0.817
CHAMP10.802
ZSCAN250.796
NUP1550.781
ZNF1320.775
XPO50.775
ZBTB90.774
PDCD110.766
DPH20.763
UTP150.763

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.403
OR4F29-0.357
KLRC3-0.314
FXYD3-0.31
MDFI-0.286
HEY2-0.285
KLRC2-0.273
ROM1-0.271
MYL3-0.268
OR4F16-0.266

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of POP1 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Thimerosal co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of POP1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Thimerosal co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of POP1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of POP1 mRNA29067470
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of POP1 gene27153756
D001280AtrazineAtrazine results in decreased expression of POP1 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of POP1 mRNA26238291
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of POP1 mRNA"19150397|2038263
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of POP1 mRNA28628672
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of POP1 mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of POP1 mRNA21932408
C006780bisphenol Abisphenol A results in decreased expression of POP1 mRNA25181051
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of POP1 mRNA28472532
C018021cobaltous chloridecobaltous chloride results in decreased expression of POP1 mRNA24386269
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of POP1 mRNA20971185
D019327Copper SulfateCopper Sulfate results in increased expression of POP1 mRNA19549813
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of POP1 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of POP1 mRNA28628672
D002945CisplatinCisplatin results in increased phosphorylation of POP1 protein22006019
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of POP1 protein23301498
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of POP1 mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of POP1 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of POP1 mRNA17942748
C024565ethylene dichlorideethylene dichloride results in increased expression of POP1 mRNA28189721
D005485FlutamideFlutamide results in decreased expression of POP1 mRNA24793618
C039281furanfuran results in increased expression of POP1 mRNA26194646
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of POP1 mRNA20044591
C492448ICG 001ICG 001 affects the expression of POP1 mRNA26191083
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of POP1 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of POP1 mRNA28628672
D007213IndomethacinIndomethacin results in decreased expression of POP1 mRNA28201806
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of POP1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of POP1 mRNA28628672
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of POP1 mRNA"24972896
D009151Mustard GasMustard Gas results in decreased expression of POP1 mRNA12884408
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of POP1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of POP1 mRNA"25554681
D009532NickelNickel results in increased expression of POP1 mRNA25583101
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of POP1 mRNA20971185
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of POP1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of POP1 mRNA22079256
D011192Potassium DichromatePotassium Dichromate results in decreased expression of POP1 mRNA23608068
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of POP1 mRNA25895662
C017947sodium arsenitesodium arsenite affects the expression of POP1 mRNA29319823
C017947sodium arsenitesodium arsenite results in increased expression of POP1 mRNA28595984
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of POP1 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of POP1 mRNA17942748
D013749TetrachlorodibenzodioxinAHR protein alternative form affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of POP1 mRNA]21215274
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of POP1 mRNA21215274
D019284ThapsigarginThapsigargin results in decreased expression of POP1 mRNA22378314
D019284ThapsigarginThapsigargin results in increased expression of POP1 protein24648495
D013849Thimerosal"[NOG protein co-treated with Thimerosal co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of POP1 mRNA"27188386
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of POP1 mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of POP1 mRNA"26179874
D014415TunicamycinTunicamycin results in decreased expression of POP1 mRNA22378314
D014520UrethaneUrethane results in decreased expression of POP1 mRNA28818685
D014635Valproic AcidValproic Acid results in decreased methylation of POP1 gene29154799
D014635Valproic AcidValproic Acid results in decreased expression of POP1 mRNA21427059
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of POP1 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000171ribonuclease MRP activity-IBA21873635  
GO:0000171ribonuclease MRP activity-IDA8918471  
GO:0003723RNA binding-HDA22658674  
GO:0004526ribonuclease P activity-IBA21873635  
GO:0004526ribonuclease P activity-IDA8918471  
GO:0004526ribonuclease P activitycontributes_toIDA16723659  
GO:0005515protein binding-IPI15096576  
GO ID GO Term Qualifier Evidence PubMed
GO:0001682tRNA 5'-leader removal-IDA16723659  
GO:0008033tRNA processing-IBA21873635  
GO:0016078tRNA catabolic process-IDA8918471  
GO:0090502RNA phosphodiester bond hydrolysis, endonucleolytic-IBA21873635  
GO:0090502RNA phosphodiester bond hydrolysis, endonucleolytic-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000172ribonuclease MRP complex-IBA21873635  
GO:0000172ribonuclease MRP complex-IDA8918471  16723659  
GO:0005615extracellular space-HDA22664934  
GO:0005654nucleoplasm-TAS-  
GO:0005655nucleolar ribonuclease P complex-IBA21873635  
GO:0005655nucleolar ribonuclease P complex-IDA8918471  
GO:0005730nucleolus-IDA-  
GO:0030681multimeric ribonuclease P complex-IDA16723659  
KEGG ID KEGG Term
hsa03008Ribosome biogenesis in eukaryotes
hsa03013RNA transport
Reactome ID Reactome Term Evidence
R-HSA-6784531tRNA processing in the nucleusTAS
R-HSA-72306tRNA processingTAS
R-HSA-8953854Metabolism of RNATAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal